Angélique Ndjoyi‐Mbiguino

Université des Sciences de la Santé

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Gaël Mourembou

Université des Sciences de la Santé

Laurent Bélec

Hôpital Européen Georges-Pompidou

Samira Zoa‐Assoumou

Université des Sciences de la Santé

Jean Bernard Lékana-Douki

Centre International de Recherches Médicales de Franceville

Didier Raoult

Aix-Marseille Université

Moulay Mustapha Ennaji

Université Hassan II Mohammedia

Pierre‐Edouard Fournier

Méditerranée Infection Foundation

François‐Xavier Mbopi‐Kéou

Université de Yaoundé I

Ali Si‐Mohamed

Centre Hospitalier Universitaire Dijon Bourgogne

Jaishriram Rathored

Datta Meghe Institute of Medical Sciences

Cooperative Institutions

Université des Sciences de la Santé

Inserm

German Center for Infection Research

Centre International de Recherches Médicales de Franceville

Université Paris Cité

Assistance Publique – Hôpitaux de Paris

Institut de Recherche pour le Développement

Centre National de la Recherche Scientifique

Aix-Marseille Université

Méditerranée Infection Foundation

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Seroprevalence of hepatitis B virus markers of infection and immunity among people of living in Libreville, Gabon

IJID Regions (2024)

Samira Zoa‐Assoumou Hervé M’boyis-Kamdem Pélagie Mougola-Bissiengou Guy Francis Nzengui-Nzengui Claudine Kombila-Koumavor

Seroprevalence

Hepatitis virus

10.1016/j.ijregi.2024.100448

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Citations (0)

High Prevalence of Respiratory Viral Infections in Patients Hospitalized in an Intensive Care Unit for Acute Respiratory Infections as Detected by Nucleic Acid-Based Assays

Journal of Clinical Microbiology (2005)

Jérôme LeGoff Emmanuel Guérot Angélique Ndjoyi‐Mbiguino Mathieu Matta Ali Si‐Mohamed

Forty-seven bronchoalveolar lavages (BAL) were obtained from 41 patients with acute pneumonia attending an intensive care unit. By molecular diagnosis, 30% of total BAL and 63% of bacteria-negative BAL were positive for respiratory viruses. Molecular detection allows for high-rate detection of respiratory viral infections in adult patients suffering from severe pneumonia.

10.1128/jcm.43.1.455-457.2005

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Citations (37)

Ebola and Marburg Virus: A Brief Review

Elsevier eBooks (2019)

Angélique Ndjoyi‐Mbiguino Samira Zoa‐Assoumou Gaël Mourembou Moulay Mustapha Ennaji

Marburg virus

Ebola vaccine

10.1016/b978-0-12-819400-3.00011-9

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Citations (1)

Human papillomavirus genotypes distribution in cervical cancer cases in Gabon

Infectious Agents and Cancer (2016)

Samira Zoa‐Assoumou Angélique Ndjoyi‐Mbiguino Barthélemy Mabika Mabika Ernest Bélembaogo Abdelkim Khattabi

Cervical cancer is a real public health problem in African countries. The relation between HPV and cervical cancer is well established. However, it is known that the distribution of HPV genotypes differ geographically and this may influence the effectiveness of the three available vaccines, which among other HPV genotypes targets the genotypes 16 and 18 that cause about 70 % of cervical cancers cases. The objective of this study was to identify for the first time the HPV genotypes distribution in cervical cancer specimens obtained from Gabonese women.

10.1186/s13027-016-0091-8

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Citations (12)

Évaluation de trousses de dépistage de l’infection à VIH au Gabon

Cahiers d'études et de recherches francophones / Santé (2005)

Angélique Ndjoyi‐Mbiguino Laurent Bélec

Neuf trousses commerciales de depistage des anticorps seriques contre le virus de l’immunodeficience humaine (VIH) ont ete evaluees a l’aide d’un panel de 170 serums d’adultes vivant au Gabon. Avec les techniques de reference, 96 serums etaient exempts d’anticorps et dans 74 serums des anticorps diriges contre le VIH de type 1 (n = 72) ou contre le VIH de type 2 (n = 2) etaient detectes. Pour deux trousses, la sensibilite etait inferieure a 99 % et trois d’entre elles presentaient une specificite inferieure a 95 %. Au total, par rapport au panel de reference de serums gabonais, quatre trousses sur neuf repondaient aux criteres d’acceptabilite selon les criteres de l’Organisation mondiale de la sante (OMS) : sensibilite > 99 %, specificite > 95 %. Trois trousses, disponibles au Gabon, (Determine™ HIV-1/2 ; Genscreen ® Plus HIV Ag-Ab ; Immunocomb ® II HIV1&2 BiSpot) ont finalement ete retenues selon ces criteres. Parmi 18 configurations de strategies diagnostiques alternatives evaluees en utilisant ces trois trousses, certaines configurations de la strategie II de l’OMS (deux tests sequentiels), et toutes les configurations de la strategie III de l’OMS (trois tests sequentiels) permettaient de diagnostiquer avec le maximum de fiabilite l’infection par le VIH-1 en contexte gabonais (sensibilite, specificite, valeur predictive positive et valeur predictive negative de 100 %). La configuration utilisant la trousse Determine™ HIV-1/2 comme premier test de depistage, puis Genscreen ® Plus HIV Ag-Ab comme trousse de confirmation, et enfin, Immunocomb ® II HIV1&2 BiSpot comme troisieme trousse de discrimination des serums discordants avec les deux premieres trousses de depistage, constituait la meilleure configuration, associant une excellente fiabilite tout en etant la moins couteuse des configurations evaluees. La configuration associant deux tests rapides, Immunocomb ® II HIV1&2 BiSpot suivie de Determine™ HIV-1/2, etait egalement tres fiable et plus simple a realiser (absence de necessite d’une chaine Elisa), mais son cout etait deux fois plus eleve que celui de la configuration associant trois trousses sequentielles. En conclusion, dans les laboratoires equipes, l’utilisation sequentielle de trois trousses comprenant deux tests rapides et une trousse Elisa combines apparait comme la meilleure configuration a la fois en termes de fiabilite et de cout. Dans le cas contraire, l’utilisation sequentielle de deux tests rapides permet un depistage tout aussi fiable mais plus onereux.

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Performance of rapid HIV-1/HIV-2 INSTI® on plasma and capillary blood for serological diagnosis of non B subtypes and circulating recombinant forms of HIV-1 in Gabon

Médecine et Maladies Infectieuses (2015)

Angélique Ndjoyi‐Mbiguino G.F. Nzengui Nzengui Leman Robin Hervé M’boyis Kamdem Laurent Bélec

10.1016/j.medmal.2015.05.003

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Citations (3)

Acute dengue virus 2 infection in Gabonese patients is associated with an early innate immune response, including strong interferon alpha production

BMC Infectious Diseases (2010)

Pierre Becquart Nadia Wauquier Dieudonné Nkoghe Angélique Ndjoyi‐Mbiguino Cindy Padilla

Dengue is now a leading cause of morbidity and mortality throughout the tropics. We conducted the first ex vivo study of dengue fever (DF) in African patients infected during the first Gabonese dengue virus 2 (DENV-2) outbreak in 2007, in order to investigate cytokine production, including the antiviral cytokine IFN-α, reported to be a potent inhibitor of DENV replication in vitro. Levels of 50 cytokines, chemokines and growth factors were measured in plasma from 36 patients with DENV-2 infection, and in uninfected controls, using Luminex multiplex technology. The results were interpreted according to the day of sampling after symptom onset. PBMC from six patients were also studied for T lymphocyte cell surface marker expression by flow cytometry. Acute DENV-2 infection elicited high levels of several pro-inflammatory cytokines (IL-6 and IL-17), chemokines (MIF, RANTES, IP-10 and MCP-1) and growth factors (G-CSF, GM-CSF and VEGF-A). We also observed high levels of IFN-α for the first time in adult DF patients, and CD4+ and CD8+ T cell activation at symptom onset. Acute DENV-2 infection in African patients elicits a strong innate response involving IFN-α production, as well as an adaptive immune response.

Medical microbiology

10.1186/1471-2334-10-356

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Citations (66)

Genital shedding of herpes simplex virus type 2 in childbearing-aged and pregnant women living in Gabon

International Journal of STD & AIDS (2006)

Francis Ozouaki Angélique Ndjoyi‐Mbiguino Jérôme LeGoff Isabelle Ndombi Onas Éric Kendjo

The prevalence of genital shedding of herpes simplex virus (HSV)-2 and related risk factors was evaluated in a prospective population of 355 women attending the Maternity Joséphine Bongo, in Libreville, Gabon. We found a high prevalence (66%) of HSV-2 seropositivity, with a high proportion, 14%, of women harbouring HSV-2 DNA shedding in their genital secretions. HSV-2 genital shedding was positively associated with previous episodes of genital blisters, current genital ulcer, current genital blister, HIV seropositivity and HSV-2 seropositivity. The high prevalence of HSV-2 in childbearing-aged population indicates that young women living in Gabon are at high risk for HIV acquisition in HIV-seronegative women sexually exposed to HIV, for HIV transmission in HIV-infected women co-infected by HSV-2 and finally for HSV-2 vertical transmission during pregnancy.

Sex organ

Viral Shedding

Herpes Genitalis

Genital ulcer

10.1258/095646206775455711

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Citations (15)

Noncontiguous finished genome sequence and description of Gabonia massiliensis gen. nov., sp. nov.

New Microbes and New Infections (2015)

Gaël Mourembou Jaishriram Rathored Angélique Ndjoyi‐Mbiguino Jean Bernard Lékana-Douki Florence Fenollar

Culturomics coupled with taxonogenomics is currently used to isolate and characterize new bacteria. Here we describe the features and complete genome sequence of Gabonia massiliensis strain GM3, an anaerobic Gram negative, non-spore-forming and catalase-positive bacillus isolated from a stool specimen of a healthy Gabonese male youth. Belonging to a new genus called Gabonia, it exhibits a genome of 4 261 752 bp including 37.9% GC content and 3,288 predicted genes.

Strain (injury)

Bacillus (shape)

10.1016/j.nmni.2015.11.002

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Citations (11)

Hepatitis B, C, and E infection among HIV-infected patients in Franceville, Gabon: retrospective cross-sectional study

Médecine et Santé Tropicales (2017)

Berthold Bivigou‐Mboumba François Rouet Augustin Mouinga‐Ondémé Luc Deleplancque Jeanne Sica

Access to antiretrovirals has increased the life expectancy of patients living with HIV. However, HIV-viral hepatitis coinfections in countries endemic for these infections make management more difficult. To determine the extent of these coinfections in Gabon, we investigated markers of hepatitis B, C, and E viruses in 762 adults infected with HIV-1 by ELISA. We used real-time PCR to quantify plasma HBV DNA (HBV VL) and amplified HCV and HEV RNA by nested RT-PCR and PCR.The seroprevalence of chronic hepatitis B infection was 9.3 %. Among patients with isolated HBcAc profiles, the prevalence of occult hepatitis B infection was 26.7 %, for a real prevalence (detectable CV-HBV) of 17.3 % of the total population. HCV seroprevalence was 8.8 %. Of the 67 HIV-positive patients, 76.1 % had replicative profiles (detectable HCV RNA), that is, 6.7 % of the total population. For hepatitis E, seroprevalence was 3.5 %. No case of chronic HEV infection was found. In conclusion, this study highlights a high rate of HIV-Hepatitis B, C and E coinfections in Gabon. In addition, we show the interest of looking for chronic infections (replicative profiles) in HIV-infected patients in Gabon. The establishment of technical platforms for this type of research, accessible to middle-income countries, is necessary.

Seroprevalence

Hepatitis C

Hepatitis B

Viral Hepatitis

10.1684/mst.2017.0698

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Citations (11)