Existing inconclusive data on the relationship between vitamin D status and human glucose homeostasis suggests that other factors, such as adiposity, might influence this relationship. The present study aimed to investigate the association between 25-hydroxyvitamin D [25(OH)D] and fasting plasma glucose (FPG) in the context of different amounts of total body fat in a healthy community-based population in Bangkok, Thailand.This cross-sectional study was a part of health survey of employees of the Electricity Generating Authority of Thailand. There were 1,990 healthy subjects (72.8% male) in this study. Total body fat was measured by bioelectrical impedance analysis. Total serum 25(OH)D, 25(OH)D3 and 25(OH)D2 were measured by LC-MS/MS.Age (r = 0.134, p < 0.001) and FPG (r = 0.089, p < 0.001) were positively correlated with 25(OH)D levels, while total body fat mass (r = -0.049, p = 0.03) were negatively correlated with 25(OH)D levels. 25(OH)D levels were higher in males than in females (65.0 ± 0.5 vs. 53.5 ± 0.5 nmol/L, p < 0.001). After controlling for age, gender and total fat mass, FPG was no longer correlated with 25(OH)D. However, when subjects were stratified according to fat-free mass tertiles and controlled for age and gender, there was a positive, although weak association between 25(OH)D levels and FPG (p = 0.01) in the lowest tertile.We therefore speculate that adiposity might influence the relationship of vitamin D status and FPG.

Bioelectrical Impedance Analysis

Thais

10.1186/1472-6823-13-60

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Citations (17)

Peer Review #2 of "Targeted metabolomics suggests a probable role of the FTO gene in the kynurenine pathway in prediabetes (v0.1)"

Suwannee Chanprasertyothin Nisakron Thongmung Piyamitr Sritara Boonsong Ongphiphadhanakul La‐or Chailurkit

Background.Genome-wide association studies have identified the alpha-ketoglutarate dependent dioxygenase gene (FTO) as the first susceptibility gene of obesity.In the present study, we utilized targeted metabolomics in an attempt to further elucidate mechanisms underlying the action of the FTO gene.Methods.This study was part of a health survey of employees of the Electricity Generating Authority of Thailand (n = 79, 10 female and 69 male).Targeted metabolomics was performed by liquid chromatography-mass spectrometry using Biocrates AbsoluteIDQ-p180 kit.Genotyping of FTO rs9939609 was performed by real-time PCR (TaqMan® MGB probes).Results.Using OPLS-DA variable importance in projection (VIP), tryptophan was found to be among the metabolites with the 10 highest VIP scores.Pearson's correlation analysis showed that kynurenine and tryptophan were positively correlated only in subjects with the rs9939609 A allele (n = 32, r = 0.56, p < 0.001) and the correlation coefficients were significantly higher in subjects having the A allele than in those without the A allele (p < 0.05).Moreover, the kynurenine/tryptophan ratio was significantly associated with the presence of the A allele, independently of body mass index and sex.Conclusions.The FTO gene is likely to influences the conversion of tryptophan to kynurenine.

Kynurenine pathway

Prediabetes

10.7287/peerj.13612v0.1/reviews/2

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Vitamin D receptor gene polymorphism is associated with urinary calcium excretion but not with bone mineral density in postmenopausal women

Journal of Endocrinological Investigation (1997)

Boonsong Ongphiphadhanakul Rajata Rajatanavin Suwannee Chanprasertyothin La‐or Chailurkit Noppawan Piaseu

Urinary calcium

Gene polymorphism

Bone remodeling

Linkage Disequilibrium

10.1007/bf03346915

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Citations (34)

Relationship of body composition and circulatory adiponectin to bone mineral density in young premenopausal women.

PubMed (2006)

Suwannee Chanprasertyothin Sunee Saetung Penpan Payattikul Rajata Rajatanavin Boonsong Ongphiphadhanakul

Adiponectin is a recently discovered hormone secreted by adipocytes. Adiponectin plays an important role in the regulation of insulin sensitivity as well as the propensity to inflammation and atherosclerosis. In the present study, the authors explore the relationship between adiponectin and bone mass in premenopausal women. The relationship of fat mass compared to lean body mass to bone mass was also investigatedTwo hundred premenopausal women aged between 20 and 40 years were studied. Bone mineral density (BMD) was measured at L2-4 and femoral neck by dual-energy X-ray absorptiometry (DEXA). Serum adiponectin concentrations were measured by radioimmunoassay.At the lumbar spines, factors associated with BMD were age (p < 0.01) and lean body mass (p < 0.001). No independent association with fat mass was demonstrated Likewise, at the femoral neck, only lean body mass was related to BMD (p < 0. 01). In terms of the relation of serum adiponectin to BMD, no association of serum adiponectin to BMD at the lumbar spines or femoral neck was foundAltogether, the present findings do not suggest the independent role of adiponectin in the accrual of bone mass in females, although such a role still cannot be excluded in men or postmenopausal women.

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Association between ApoA1 Gene, Plasma Lipid Profile, hsCRP Level, and Risk of Arterial Stiffness in Thai Elderly

Advances in Preventive Medicine (2022)

Pruttaya Supajaree Suwannee Chanprasertyothin Prapimporn Chattranukulchai Shantavasinkul Piyamitr Sritara Jintana Sirivarasai

Apolipoprotein A1 (ApoA1) gene polymorphism is linked to high-density lipoprotein cholesterol (HDL-C) levels. Variations in this gene, along with dyslipidemia and inflammation, may increase the risk of vascular stiffness. This study aimed to investigate the link between ApoA1 rs670 genetic variations, various biochemical parameters, and the risk of arterial stiffness in older people.

Dyslipidemia

Lipid Profile

10.1155/2022/4930033

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The Association of Soluble IGF2R and IGF2R Gene Polymorphism with Type 2 Diabetes

Journal of Diabetes Research (2015)

Suwannee Chanprasertyothin Wallaya Jongjaroenprasert Boonsong Ongphiphadhanakul

The aim of this study is to investigate the insulin-like growth factor type 2 (IGF2R) gene and circulating soluble IGF2R in relation to type 2 diabetes (T2DM). Six hundred fifty-four subjects without history of diabetes were screened for diabetes by oral glucose tolerance test. In addition, 145 subjects with known diabetes were recruited from a local diabetes clinic. Circulating IGF2R levels were measured by ELISA method; plasma glucose was measured by colorimetric method; insulin levels were determined by chemiluminescent method; IGF2R gene rs416572 was genotyped using real-time PCR. The distributions of IGF2R genotypes were 69.2% CC, 27.8% CT, and 3.0% TT. The C allele was more commonly found in diabetes subjects, with a significant difference (P < 0.01). In the presence of the T allele, circulating IGF2R levels were significantly lower (P < 0.05). There was no significant difference in other potential confounders including age, sex, and BMI. Only circulating IGF2R, age, and BMI were independently associated with the degree of insulin resistance, as assessed by the HOMA model. It was found that age, sex, and BMI were associated with beta cell function. In conclusion, IGF2R gene polymorphism and circulating IGF2R are associated with T2DM.

10.1155/2015/216383

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The Detection of SARS-CoV2 Antigen in Wastewater Using an Automated Chemiluminescence Enzyme Immunoassay

International Journal of Environmental Research and Public Health (2022)

Supranee Thongpradit Somsak Prasongtanakij Supanart Srisala Suwannee Chanprasertyothin Ekawat Pasomsub

The SARS-CoV-2 virus, which is driving the current COVID-19 epidemic, has been detected in wastewater and is being utilized as a surveillance tool to establish an early warning system to aid in the management and prevention of future pandemics. qPCR is the method usually used to detect SARS-CoV-2 in wastewater. There has been no study using an immunoassay that is less laboratory-intensive than qPCR with a shorter turnaround time. Therefore, we aimed to evaluate the performance of an automated chemiluminescence enzyme immunoassay (CLEIA) for SARS-CoV-2 antigen in wastewater. The CLEIA assay achieved 100% sensitivity and 66.7% specificity in a field-captured wastewater sample compared to the gold standard RT-qPCR. Our early findings suggest that the SARS-CoV-2 antigen can be identified in wastewater samples using an automated CLEIA, reducing the turnaround time and improving the performance of SARS-CoV-2 wastewater monitoring during the pandemic.

10.3390/ijerph19137783

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Serum leptin concentrations in relation to body fat, gender, sex hormones and metabolic covariates in Thais.

PubMed (1999)

Boonsong Ongphiphadhanakul R Rajatanavin Suwannee Chanprasertyothin Noppawan Piaseu La‐or Chailurkit

In the present study, the relation of serum leptin to adiposity, gender and metabolic covariates in normal Thais was examined. Subjects consisted of 224 individuals aged between 20-79 years. Eighty two were men while 142 were women. Data were expressed as mean +/- SEM. Serum leptin was associated with total body fat assessed by dual-energy X-ray absorptiometry in both men (r = 0.80, P < 0.0001) and women (r = 0.73, P < 0.0001). Compared to women, serum leptin concentrations was lower in men (P < 0.0001). The difference still persisted after controlling the adiposity. Compared to premenopausal women, postmenopausal women had higher serum leptin independent of adiposity (P < 0.0001). In men, serum free testosterone was negatively associated with serum leptin (r = -0.36, P < 0.001) while there was no association between serum estradiol and leptin. The relation between serum FT and leptin in men no longer persisted after controlling for adiposity. Body fat was associated with fasting insulin levels in both men (r = 0.26, P < 0.05) and women (r = 0.18, P < 0.05). However, the association between fasting insulin levels and body fat in both men and women no longer existed after adjusting for leptin. We concluded that serum leptin concentrations are associated with total body adiposity and serum leptin may mediate the effect of body fat on insulin sensitivity. There appears to be a sexual dimorphism of serum leptin unrelated to sex hormone status and the amount of body fat.

Thais

Sex characteristics

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The effects of oestrogen exposure on bone mass in male to female transsexuals

Clinical Endocrinology (1998)

Sirimon Reutrakul Boonsong Ongphiphadhanakul Noppawan Piaseu S. Krittiyawong Suwannee Chanprasertyothin

OBJECTIVE The importance of oestrogen on bone mineral density (BMD) in males was suggested by reports of patients with oestrogen resistance and aromatase deficiency who demonstrated osteoporosis and epiphyseal plate maturation defect despite high testosterone levels. In the present study, we examined the effects of oestrogen exposure on BMD in transsexual men. DESIGN Cross‐sectional study of BMD in male to female transsexuals. PATIENTS Subjects consisted of two groups of transsexual male dancers aged 16–34 years who did not receive transsexual operations ( n = 28). Group 1 ( n = 11) and group 2 ( n = 17) had used oestrogen for 2 years or less and more than 2 years, respectively. Twenty‐four healthy adult males served as controls. RESULTS signs of feminization were presented in both group 1 and group 2, with Tanner's stage II–III breast development. BMD at various sites were correlated only to body weight and not to smoking or milk consumption. After controlling for body weight, it was found that group 2 had significantly higher BMD at L2–4 than controls (1.22 ± 0.03 vs . 1.14 ± 0.03 g/cm 2 , P < 0.05) and group 1 (1.22 ± 0.03 vs . 1.08 ± 0.04 g/cm 2 , P < 0.05). BMD at femoral neck was also higher in group 2 compared to controls (1.10 ± 0.03 vs . 1.01 ± 0.03 g/cm 2 , P < 0.05) and group 1 (1.10 ± 0.03 vs . 0.95 ± 0.04 g/cm 2 , P < 0.05). Group 1 subjects had lower BMD compared to controls at femoral trochanter (0.70 ± 0.04 vs . 0.83 ± 0.03 g/cm 2 , P < 0.05) and total femur (0.96 ± 0.05 vs . 1.07 ± 0.03 g/cm 2 , P < 0.05). CONCLUSIONS Long‐term oestrogen exposure transsexual men result in an increase in bone mineral density despite signs of feminization. This suggests that oestrogen has positive effects on bone density in males. The finding of the trend towards reduced bone density in group 1 remains unexplained.

Testicular feminization

Feminization (sociology)

Breast development

10.1046/j.1365-2265.1998.00614.x

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Citations (55)