Masateru Ikehata

Railway Technical Research Institute

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Takao Koana

Central Research Institute of Electric Power Industry

Sachiko Yoshie

Railway Technical Research Institute

Yukihisa Suzuki

Tokyo Metropolitan University

Junji Miyakoshi

Kyoto University

Yoshio Takashima

National Institutes for Quantum and Radiological Science and Technology

Satoshi Nakasono

Central Research Institute of Electric Power Industry

Masakazu Iwasaka

Hiroshima University

Masao Taki

National Institute of Information and Communications Technology

Keiji Wãda

Tokyo Metropolitan University

Yuji Suzuki

Iwate Medical University

Cooperative Institutions

The University of Tokyo

Railway Technical Research Institute

Tokyo Metropolitan University

Central Research Institute of Electric Power Industry

Meiji Pharmaceutical University

Japan Atomic Energy Agency

Kyoto University

National Institute of Public Health

Tokyo University of Agriculture and Technology

Kyushu University

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Increase in the mitotic recombination frequency in Drosophila melanogaster by magnetic field exposure and its suppression by vitamin E supplement

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis (1997)

Takao Koana Mikie O. Okada Masateru Ikehata Masayoshi Nakagawa

Mitotic crossover

10.1016/s0027-5107(96)00188-1

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Citations (49)

Indium Chloride‐induced Micronuclei in In Vivo and In Vitro Experimental Systems

Journal of Occupational Health (2011)

Ryo Takagi Yuji Suzuki Yoshiko Seki Masateru Ikehata Chieko Kajihara

Indium Chloride‐induced Micronuclei in In Vivo and In Vitro Experimental Systems: Ryo Takagi, et al. Department of Public Health and Environmental Medicine, Jikei University School of Medicine— Objectives The aim of this study was to investigate the genotoxic effects of indium trichloride (InCl 3 ·4H 2 O; InCl 3 ) using the in vivo bone marrow micronucleus test and the in vitro CHL/IU cell micronucleus test. Method BALB/c mice were administered a single intraperitoneal (i.p.) injection of InCl 3 at a dose 0.625, 1.25, 2.5, 5, or 10 mg/kg b.w. The frequency of micronuclei, the ratio of polychromatic erythrocytes to normochromatic erythrocytes (P/N ratio) and body weight gain were determined 24 h after administration of the InCl In the in vitro micronucleus test, CHL/IU cells were treated continuously for 24, 48, or 72 h in the absence of S9mix (the continuous treatment method) and/or for 6 h with or without S9 mix followed by an 18, 42 or 66 h recovery time (the short time treatment method). The frequency of micronuclei was determined at the end of each culture period. Results The frequency of micronuclei induced by InCl 3 increased in the in vivo erythroblast‐erythrocyte micronucleus test using BALB/c mice at doses of 2.5 and 5 mg/kg b.w. The P/N ratio, a marker of bone marrow toxicity, decreased significantly following the injection of InCl 3 . Body weight gain was also inhibited by InCl 3 . InCl 3 induced micronuclei in the CHL/IU cell micronucleus test in both the continuous treatment method and the short time treatment method, both with and without S9mix. Conclusions These results suggest that InCl 3 has a genotoxic effect on mammalian cells both in vivo and in vitro.

Intraperitoneal injection

10.1539/joh.l9142

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Citations (15)

A 50 Hz, 14 mT magnetic field is not mutagenic or co-mutagenic in bacterial mutation assays

Mutation Research/Genetic Toxicology and Environmental Mutagenesis (2000)

Satoshi Nakasono Masateru Ikehata Takao Koana Hiroshi Saiki

Acridine orange

Acridine

Mutation frequency

10.1016/s1383-5718(00)00118-2

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Citations (11)

Public Health on Electromagnetic Fields and Magnetic Shield of Linearmotorcar EDS Maglev

Springer eBooks (1996)

Motoo Nakagawa Masateru Ikehata Takao Koana

10.1007/978-0-585-31661-1_15

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Citations (3)

Estimation of mutagenic effects of intermediate frequency magnetic field using mammalian cells

Sachiko Yoshie Yukihisa Suzuki Keiji Wãda Kanako Wake Taiji Sakai

Since the opportunities that people are exposed to intermediate frequency (IF) magnetic fields (MF) are increasing, the health risk assessment of IF-MF has now become important. Because there have been few studies about long-term exposure to IF-MF with high magnetic flux density, we have developed a new apparatus capable of IF-MF exposure up to 3.9 mT for in vitro study. In this study, we found out that IF-MF did not affect both cell growth and mutagenicity using the mammalian cell line CHO-K1 and its DNA repair deficient derivatives.

10.1109/ursigass.2011.6051339

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Citations (3)

<b>Evaluation of Stimulation Threshold in Nerve Cells by Exposure to Time-varying Magnetic Field in In Vitro</b>

Quarterly Report of RTRI (2020)

Masateru Ikehata Yukihisa Suzuki Atsushi Saito Sachiko Yoshie

International guidelines that aim to protect people from adverse health effects of exposure to magnetic fields (MF) have been established by international organizations such as the International Commission on Non-Ionizing Radiation Protection (ICNIRP) or the Institute of Electrical and Electronic Engineers (IEEE). In these guidelines, one of the target effects below 100 kHz is nerve stimulation based on a few perceptual studies. Because of a few studies, the value of basic restriction of the guidelines adopt extrapolation widely such as 45 Hz to 400 Hz and 7 kHz to 100 kHz. Therefore, determination of threshold value among extrapolated frequencies is important for verification and improving of the current basic restriction. Here, we report progress of our study to determine threshold value of nerve stimulation by magnetic or electric field in in vitro.

10.2219/rtriqr.61.4_297

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Study of simple method for estimating driver's physical and mental conditions utilizing respiratory sinus arrhythmia component based on respiratory cycles

The Japanese Journal of Ergonomics (2020)

Chizuru NAKAGAWA Takahiro Watanabe Ayako Suzuki Takashi Kojima Yasuhiro Kitamura

Vagal Tone

Component (thermodynamics)

10.5100/jje.56.2g1-02

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Citations (1)

Analysis Of Global Expression Profiles In Saccharomyces cerevisiae After Exposure To Strong Static Magnetic Fields