Dominik Kosowski

Centre of Polymer and Carbon Materials

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Andrzej Dworak

Centre of Polymer and Carbon Materials

Barbara Trzebicka

Centre of Polymer and Carbon Materials

Dawid Szweda

Łukasiewicz Research Network – PORT Polish Center for Technology Development

Róża Szweda

Adam Mickiewicz University in Poznań

Emi Haladjova

Bulgarian Academy of Sciences

ŁO

Łukasz Otulakowski

Centre of Polymer and Carbon Materials

Alicja Utrata‐Wesołek

Centre of Polymer and Carbon Materials

Agnieszka Kowalczuk

Centre of Polymer and Carbon Materials

Justyna Hertlein

Centre of Polymer and Carbon Materials

Natalia Oleszko-Torbus

Centre of Polymer and Carbon Materials

Cooperative Institutions

Centre of Polymer and Carbon Materials

Polish Academy of Sciences

Bulgarian Academy of Sciences

Łukasiewicz Research Network – PORT Polish Center for Technology Development

Institute of Polymers

Institute of Macromolecular Compounds

Silesian University of Technology

University of Opole

Institute of Coal Chemistry

University of Chemical Technology and Metallurgy

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Thermoresponsive polymer-peptide/protein conjugates

Progress in Polymer Science (2016)

Barbara Trzebicka Róża Szweda Dominik Kosowski Dawid Szweda Łukasz Otulakowski

Bioconjugation

Biomolecule

Conjugate

10.1016/j.progpolymsci.2016.12.004

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Citations (78)

Smart Polymeric Nanocarriers of Met-enkephalin

Biomacromolecules (2016)

Róża Szweda Barbara Trzebicka Andrzej Dworak Łukasz Otulakowski Dominik Kosowski

This study describes a novel approach to polymeric nanocarriers of the therapeutic peptide met-enkephalin based on the aggregation of thermoresponsive polymers. Thermoresponsive bioconjugate poly((di(ethylene glycol) monomethyl ether methacrylate)-ran-(oligo(ethylene glycol) monomethyl ether methacrylate) is synthesized by AGET ATRP using modified met-enkephalin as a macroinitiator. The abrupt heating of bioconjugate water solution leads to the self-assembly of bioconjugate chains and the formation of mesoglobules of controlled sizes. Mesoglobules formed by bioconjugates are stabilized by coating with cross-linked two-layer shell via nucleated radical polymerization of N-isopropylacrylamide using a degradable cross-linker. The targeting peptide RGD, containing the fluorescence marker carboxyfluorescein, is linked to a nanocarrier during the formation of the outer shell layer. In the presence of glutathione, the whole shell is completely degradable and the met-enkephalin conjugate is released. It is anticipated that precisely engineered nanoparticles protecting their cargo will emerge as the next-generation platform for cancer therapy and many other biomedical applications.

Bioconjugation

Nanocarriers

Conjugate

Atom-transfer radical-polymerization

10.1021/acs.biomac.6b00725

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Citations (21)

Thermoresponsive polymer surfaces and their application in tissue engineering

Polimery (2018)

Alicja Utrata‐Wesołek Natalia Oleszko-Torbus Marcelina Bochenek Dominik Kosowski Agnieszka Kowalczuk

This short review addresses the synthesis of thermoresponsive polymer surfaces and their application for cell tissue engineering. Four classes of synthetic thermoresponsive polymers are discussed: poly(N-isopropylacrylamide)s, poly[oligo(ethylene glycol)methacrylate]s, polyoxazolines and polyethers, most notably, polyglycidol. Synthetic routes leading to thermoresponsive layers on solid support are described. Relationships between structures of the layers and their interactions with cells are analyzed. Chemical (copolymerization or the inclusion of biologically active species) and physical (patterning or themorphology of the surfaces) modifications of macromolecular surfaces are described and their relations to the growth and detachment of cell sheets are reviewed. The application of cell sheets grown and detached from thermoresponsive surfaces to treat diseases is also presented.

10.14314/polimery.2018.5.1

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Citations (16)

Polymer-peptide/protein conjugates on the surface

Current Organic Chemistry (2017)

Róża Szweda Dawid Szweda Dominik Kosowski Andrzej Dworak Barbara Trzebicka

Background: Polymer-peptide/protein conjugates immobilized on surface have gained considerable attention, mostly due to their broad scope of applications in biomedical fields. To optimize their properties, the combined knowledge of polymer chemistry and biochemistry has to be applied. Keywords: Polymer bioconjugates; polymer surfaces; peptide/protein surfaces; polymeric linkers; structure-property relationship; peptide conjugates.

Conjugate

Scope (computer science)

Protein chemistry

10.2174/1385272821666170518170356

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Citations (4)