Xuanjia Chen

Hunan Institute of Science and Technology

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Xiaoyan Zhang

Zhengzhou University

Dachun Zhao

Chinese Academy of Medical Sciences & Peking Union Medical College

Jing Kong

Kunming Medical University

Yuxin Jiang

Chinese Academy of Medical Sciences & Peking Union Medical College

Na Li

Macau University of Science and Technology

Hongyan Wang

Chinese Academy of Medical Sciences & Peking Union Medical College

Wei Ye

Peking Union Medical College Hospital

Jianchu Li

Peking Union Medical College Hospital

Zhangjie Wu

Ministry of Industry and Information Technology

Yu Gao

Shanghai Jiao Tong University

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Chinese Academy of Medical Sciences & Peking Union Medical College

Peking Union Medical College Hospital

Hunan Institute of Science and Technology

Capital Medical University

Zhengzhou University

Anhui Medical University

Sun Yat-sen University

Beijing Children’s Hospital

Weatherford College

Shanghai Jiao Tong University

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Assessment of left ventricular twist of patients with hypertension by three-dimensional speckle tracking imaging

Zhonghua chaosheng yingxiangxue zazhi (2014)

Xuanjia Chen Jianhua Wang Minyu Zhang Mei Liu Yu Gao

Objective To observe features of twist of the left ventricle (LV) in patients of essential hypertension (EH) with LV normal geometry (LVN) by three-dimensional speckle tracking imaging (3D-STI).Methods Thirty EH patients with LVN and 32 healthy control subjects were included.From the dynamic images of LV apical two-and four-chamber-views and three-dimensional full volume dataset acquired,the following parameters were obtained:peak of LV basal,middle and apical segment rotation (Prot-B,Prot-M and Prot-A),peak of LV global segment twist (LV-tw) and rotation (LV-rot),the global radial and longitudinal displacement (Dr,Dl) and the global 3D displacement (D3d).The difference of these parameters was compared between EH and control groups,and the correlation between LV-tw and the displacements in EH group was studied.Results Compared with the normal control group,Prot-B,Prot-M,Prot-A,LV-tw,LV-rot,Dr,Dl and D3d of EH group were significantly increased (P ＜ 0.01 or 0.05),and LV-tw showed significant correlation with Dr,Dl and D3d (P ＜0.01 or 0.05).Conclusions The evaluation of LV twist with 3DSTI in EH patients can reflect the changes of LV systolic function in early stage,3D-STI may provide a new modality for quantitative evaluation of early abnormality of LV function in clinical practice. Key words: Echocardiography; Hypertension; Ventricular function, left; Twist; Speckle tracking imaging, three-dimensional

Basal (medicine)

Essential hypertension

10.3760/cma.j.issn.1004-4477.2014.04.004

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Neovascularization in carotid atherosclerotic plaques can be effectively evaluated by superb microvascular imaging (SMI): Initial experience

Vascular Medicine (2020)

Xuanjia Chen Hongyan Wang Yuxin Jiang Jianchu Li Na Li

The objective of this study was to investigate the correlation between the amount of blood flow in the area of neovascularization within a carotid atherosclerotic plaque by superb microvascular imaging (SMI) and the microvessel density (MVD) determined by histopathological staining. Twenty-eight carotid atherosclerotic plaques were detected by SMI in 28 patients who underwent carotid endarterectomy. SMI was graded according to the visual methods as follows: grade I: no appearance of neovascularization within the plaque; grade II: punctate neovascularization; grade III: one or two linear neovascularizations within the plaque; and grade IV: multiple (> 2) linear neovascularizations throughout the plaque. The neovascularization density was determined by the CD31 complex staining method. There was a significant correlation between the density of neovascularization in histopathologic plaques and the blood flow grade found by SMI ( r = 0.788, p < 0.001). A significant difference was observed in SMI blood flow grade between the symptomatic and asymptomatic groups (χ 2 = 2.634, p = 0.036). The MVD of plaques in the symptomatic group was significantly higher than that in the asymptomatic group ( t = 2.530, p = 0.018). The SMI-based classification was positively correlated with plaque thickness. SMI, which is a new nonultrasound contrast-enhanced imaging method, can effectively evaluate neovascularization in carotid atherosclerotic plaques and can be used as a novel method for the clinical prediction of stroke risk.

CD31

Vulnerable plaque

Stroke

10.1177/1358863x20909992

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Construction of hierarchical core-shell structured CoSe2@Fe3O4@Fe2O3 composite as advanced anodes for sodium ion batteries

IOP Conference Series Earth and Environmental Science (2021)

Shi Luo Chenghao Chen Ruojin Feng Xuanjia Chen Wenlin Chen

Abstract Transition metal selenides/oxides have received extensive attention, due to there suitable voltage plateaus and abundant reserves. However, intrinsic low electrons conductivity and huge volume change during sodiation/desodiation progress limit its wide application. To address these issues, CoSe 2 @Fe 3 O 4 @Fe 2 O 3 with heterogeneous structure was successfully synthesized. As a SIBs anodes, the CoSe 2 @Fe 3 O 4 @Fe 2 O 3 composite presents high electrochemical reversibility with a capacity of 360 mA h g −1 after 100 cycles at 100 mA g −1 .

10.1088/1755-1315/844/1/012008

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Comparison between superb microvascular imaging and histopathology for the evaluation of carotid artery atherosclerotic plaque neovascularization

Chin J Health Manage (2019)

Xuanjia Chen Hongyan Wang Yuxin Jiang Jianchu Li Na Li

Objective To investigate the significance of superb microvascular imaging (SMI) for the detection of neovascularization in carotid atherosclerotic plaques. Methods SMI detected 28 carotid atherosclerotic plaques in 28 patients who underwent carotid endarterectomy. The SMI grade of carotid plaque neovascularization was assigned based on the following grading system: Grade 0, no neovascularization; grade 1, some neovascularization; grade 2, neovascularization observed in the shoulder of the plaque; and grade 3, widely distributed new blood vessels. SMI was used to evaluate the degree of blood flow, maximum flow velocity, and resistance index of the new vessels in the plaque. Microvascular density was measured with CD31 staining. Results Clear correlations were observed between neovascularization density on histopathological staining of the plaque and the degree of blood flow detected with SMI (rs=0.788, P < 0.001). The classification of neovascular blood flow in the plaque was positively correlated with plaque thickness (rs=0.686, P=0.002). Of the 28 cases, neovascularization was detected in 23; of these 23 cases, the direction of blood flow was from the adventitia to the intima in 17 (75%) cases, while 6 (25%) cases showed an irregular direction of blood flow. The mean neovascular flow velocity was (5.620±0.131) cm/s, and the mean neovascular resistance index was 0.660±0.090. Conclusion SMI is useful for the evaluation of carotid atherosclerotic plaque neovascularization. Key words: Ultrasonography; Carotid arteries; Atherosclerosis; Neovascularization; Histopathology

CD31

10.3760/cma.j.issn.1674-0815.2019.02.003

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