This paper presents the results of a joint study of automatic diagnosis of chest radiographs of pneumoconiosis. The Hybrid Optical/Digital Image Processing System of Fudan University (OPSA-1) was used. New algorithms developed for feature selection and classification led to a higher efficiency through experiments, with 94% accuracy in discriminating normal/abnormal radiographs.
The evaluation methods of immune persistence include direct evaluation, indirect evaluation, model prediction, and meta-analysis and so on. Direct evaluation is the gold standard for evaluating the immune persistence of vaccines by quantifying the protective effect of vaccines on the onset and (or) infection of preventable diseases. Indirect evaluation of immune persistence by immunological surrogate indicators is more widely used in practice. In addition, mathematical models and meta-analysis can also be used to evaluate the immune persistence of vaccines. It is of great significance to select the appropriate evaluation method to analyze the immune persistence of the vaccine according to the specific situation.疫苗的免疫持久性评价方法包括直接评价、间接评价以及模型预测、Meta分析等方法。直接评价通过评价疫苗对所预防疾病发病和（或）感染的保护作用来评价疫苗的免疫持久性，是疫苗的免疫持久性评价的金标准。通过免疫学替代指标间接评价疫苗的免疫持久性，在实践中应用更为广泛。此外，数学模型、Meta分析等方法也可用于疫苗的免疫持久性评价。结合具体情况选择恰当的评价方法分析疫苗的免疫持久性，对完善疫苗免疫策略具有重要意义。.
To investigate the effects of penehyclidine combined with edaravone on acute cerebral infarction (ACI) in rats.A rat model of middle cerebral artery infarction was created. The rats were randomly divided into sham, model and treatment group. After grouping, rats in the treatment groups were treated with edaravone combined with phenecyclidine. The rats in the sham and model group were given an equal volume of phosphate-buffered saline (PBS). The therapeutic effects on rats at 3 d and 7 d after treatment were observed, the levels of serum TNF-α, interleukin-6 (IL-6) and high-mobility group box 1 protein (HMGB1) before and after treatment were compared, and the NDS scores were recorded.After treatment, the effective rate in treatment groups was higher than that in control group. The expression levels of serum TNF-α, HMGB1 and IL-6 in treatment groups showed gradually decreasing trends after treatment, and there were significant differences in the levels before and after treatment (p<0.05). At 3 d, the decrease ranges of expression levels of TNF-α, HMGB1, and IL-6 in model and treatment groups were larger than those in control group; there were statistically significant differences in the expression levels between the two groups (p<0.05). The NDS score was gradually decreased after treatment, while the activities of daily living (ADL) score were gradually increased after treatment. There were significant differences in the scores between the two groups at each time point (p<0.05). There were positive correlations of the expression levels of serum IL-6 and HMGB1 with the expression level of TNF-α (correlation coefficient=0.8731 and 0.9084, p<0.01), and there was also a positive correlation between the TNF-α level and the NDS score (correlation coefficient=0.8331, p<0.01).Penehyclidine combined with edaravone has a better clinical treatment effect on ACI rats, which can significantly reduce the levels of serum TNF-α, IL-6 and HMGB1 and the NDS score, so it is worthy of popularization in clinical application.
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