I.A.D. Bouchier

Ninewells Hospital

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i-10 index

Research Field

Cholesterolosis: a physical cause of "functional" disorder.

BMJ (1987)

M R Jacyna I.A.D. Bouchier

Many good friends and colleagues in England and Wales may take exception to criticisms of the National Blood Transfusion Service by the national medical director of its wee sister in Scotland.Undoubtedly my critique is partly based on "self' interest: the continued decline of the National Blood Transfusion Service is now having a destabi- lising effect on the Scottish service.Nevertheless, the overriding reason for this cri de coeur is my belief that unless the vital importance of the blood transfusion services to the well being of the health services in the UK is better understood, and the decline in performance arrested, then within the next decade the consequences will be grave.

10.1136/bmj.295.6599.619

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Citations (28)

Influence of the gallbladder on serum bile acids.

Journal of Clinical Pathology (1982)

C R Pennington P E Ross I.A.D. Bouchier

Serum bile acids (SBA) were studied after a standard fatty meal in patients with gallbladder disease. Early postprandial bile acid values were found to be greater in patients with non-functioning gallbladders. Higher postprandial SBA values were found after cholecystectomy. Serum bile acid measurements were of no value in the assessment of gallbladder function.

Gallbladder disease

10.1136/jcp.35.7.754

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Citations (1)

Changes in enzyme activity in normal and histologically inflamed oesophageal epithelium.

Gut (1979)

D. Hopwood P E Ross Kathleen R. Logan Gayle Nicholson I.A.D. Bouchier

Oesophageal biopsies were obtained from 74 patinets undergoing upper gastrointestinal fibreoptic endoscopy. Thirteen patients with histological evidence of inflammation had a raised alkaline phosphatase activity (2.7 +/- 1.6 nmol/mg protein/min) compared with 49 normal controls (1.2 +/- 0.68 nmol/mg protein/min: P less than 0.001). The acid phosphatase level was lower (8.4+/- 4.0 vs. 5.8 +/- 2.2 nmol/mg protein/min: P less than 0.05) and the glucuronidase activity raised (0.44 +/- 0.17 vs 0.81 +/- 0.32 nmol/mg protein/min: P less than 0.001) and their ratio declined (24.0 +/- 1.9 nmol/mg protein/min: P less than 0.001) in patients with oesophagitis. This may be due to differential secretion of membrane coating granules, a form of lysosome found isophagitis--was assessed by point counting. The volume density rose from 10.9 +/- 4.25% in normal biopsies to 46.4+/-12.5% (P less than 0.001) in oesophagitis. These results show a consistent pattern that possibly indicates an intermediate stage between the clinically, histologically, and biochemically normal oesophagus and one that is inflamed on endoscopy.

10.1136/gut.20.9.769

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Citations (6)

Book Review: Bile Acids and Lipids

Journal of the Royal Society of Medicine (1982)

I.A.D. Bouchier

10.1177/014107688207500219

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Citations (0)

The influence of captopril, the nitrates and propranolol on apparent liver blood flow.

British Journal of Clinical Pharmacology (1985)

AN Shepherd PC Hayes M R Jacyna Lucas M. Morrison I.A.D. Bouchier

Indocyanine green estimated apparent liver blood flow was measured in normal volunteers following glyceryl trinitrate, propranolol, isosorbide mononitrate and captopril. Glyceryl trinitrate and propranolol significantly reduced apparent liver blood flow. Isosorbide mononitrate did not alter apparent liver blood flow or produce an additional reduction in apparent liver blood flow when combined with propranolol. Captopril did not alter apparent liver blood flow despite a significant fall in mean arterial pressure and rise in plasma renin activity. Captopril and isosorbide mononitrate if shown to reduce portal pressure, do so without a fall in apparent liver blood flow.

Captopril

Isosorbide dinitrate

Plasma renin activity

10.1111/j.1365-2125.1985.tb02659.x

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Citations (17)

Chronic Pancreatitis in England: A Changing Picture?

BMJ (1974)

Oliver James J. E. Agnew I.A.D. Bouchier

A total of 107 patients with chronic pancreatitis from the London area seen between 1968 and 1973 have been reviewed; they comprised 30 with calcific pancreatitis and 77 with chronic or chronic relapsing pancreatitis without calcification. The commonest clinical features were pain, diabetes, malabsorption, and peptic ulcer. Alcohol was a probable aetiology in nearly half the cases, a different finding from those of previous surveys and possibly associated with the increased consumption of alcohol in England in the last 20 years.

Etiology

Chronic alcoholic

Pancreatitis, chronic

10.1136/bmj.2.5909.34

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Citations (66)

Assessment of the 14C-Glycocholic Acid Breath Test

BMJ (1973)

Oliver James J. E. Agnew I.A.D. Bouchier

The 1-((14)C)-glycine-glycocholic-acid breath test has been performed on 104 subjects and a normal range established. Abnormal results due to bacterial deconjugation of bile salts were found not only in patients with the "contaminated bowel" syndrome and in those with ileal resection but also in a third group, patients with cholangitis. Abnormal results were also found in patients with gastrocolic fistula and staphylococcal enterocolitis, while mildly abnormal results were also found in some patients with liver disease.

Glycocholic acid

Enterocolitis

10.1136/bmj.3.5873.191

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Citations (54)

Chenodeoxycholic acid therapy for hypertriglyceridaemia in men.

British Journal of Clinical Pharmacology (1978)

M.C. Bateson Derek Maclean J.E. Evans I.A.D. Bouchier

1 Ten consecutive patients with hypertriglyceridaemia who adhered to a low carbohydrate diet without complete control of serum triglycerides were started on chenodeoxycholic acid 750 mg daily and followed monthly for 6 months. Nine of these patients were then followed for a further month on placebo capsules and thereafter monthly for a further 6 months on clofibrate 2 g daily. 2 The mean serum triglyceride level fell by 36% after dietary treatment alone (P less than 0.05) and by 47% from initial values on diet plus chenodeoxycholic acid (P less than 0.01). In the nine patients who proceeded to clofibrate therapy there was a rise in triglyceride levels on placebo capsules to the level achieved by diet alone, and a further fall on diet plus clofibrate of 47% of initial values (P less than 0.05). 3 Chenodeoxycholic acid therapy is effective in the management of hypertriglyceridaemia not completely cured by dietary measures, and may be as efficacious as clofibrate.

Clofibrate

Chenodeoxycholic acid

Low carbohydrate

10.1111/j.1365-2125.1978.tb01632.x

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Citations (90)

Contents, Vol. 28, 1983

Digestion (1983)

Allen W. Mangel John R. Stavorski Robert G. Pendleton J. Pirotte D. El Allaf

10.1159/000198988

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Citations (0)