Tatiana Carrozzini

Fondazione IRCCS Istituto Neurologico Carlo Besta

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Antonella Potenza

Università di Camerino

Laura Gatti

Center for Sustainable Future Technologies

Gemma Gorla

Fondazione IRCCS Istituto Neurologico Carlo Besta

Giuliana Pollaci

Fondazione IRCCS Istituto Neurologico Carlo Besta

Anna Bersano

Fondazione IRCCS Istituto Neurologico Carlo Besta

Ignazio G. Vetrano

Fondazione IRCCS Istituto Neurologico Carlo Besta

Michele Dei

University of Milan

Isabella Canavero

Fondazione IRCCS Istituto Neurologico Carlo Besta

Sara Nava

University of Milano-Bicocca

Elena Lonati

University of Milano-Bicocca

Cooperative Institutions

Fondazione IRCCS Istituto Neurologico Carlo Besta

University of Milan

Istituti di Ricovero e Cura a Carattere Scientifico

University of Milano-Bicocca

Mylan (Switzerland)

Ospedale Maggiore

Fondazione IRCCS Istituto Nazionale dei Tumori

Ospedale San Paolo

Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico

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The Octopus Trap of Takotsubo and Stroke: Genetics, Biomarkers and Clinical Management

Journal of Personalized Medicine (2022)

Isabella Canavero Nicola Rifino Maurizio Bussotti Tatiana Carrozzini Antonella Potenza

Takotsubo cardiomyopathy (TC) is a reversible cardiomyopathy mimicking an acute coronary syndrome, usually observed in response to acute stress situations. The association between acute ischemic stroke and TC is already known, since it has been previously reported that ischemic stroke can be both a consequence and a potential cause of TC. However, the precise pathophysiological mechanism linking the two conditions is still poorly understood. The aim of our review is to expand insights regarding the genetic susceptibility and available specific biomarkers of TC and to investigate the clinical profile and outcomes of patients with TC and stroke. Since evidence and trials on TC and stroke are currently lacking, this paper aims to fill a substantial gap in the literature about the relationship between these pathologies.

Stroke

Pathophysiology

10.3390/jpm12081244

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Citations (3)

Zenodo (CERN European Organization for Nuclear Research) (2022)

Ignazio G. Vetrano Michele Dei Marica Eoli Antonella Potenza Tatiana Carrozzini

Lipid species derived from analyses, anonymized sample series

10.5281/zenodo.5883312

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Citations (0)

Neutral lipid reshaping in Blood Brain Barrier is induced in modelled ischemia-reperfusion.

Elena Lonati C. De Paola Zoi Stefania M Gigliola Tatiana Carrozzini

Source

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Angiopoietin‐2 associates with poor prognosis in Moyamoya angiopathy

Annals of Clinical and Translational Neurology (2024)

Gemma Gorla Antonella Potenza Tatiana Carrozzini Giuliana Pollaci Francesco Acerbi

Abstract Objective Moyamoya angiopathy (MA) is a rare cerebrovascular disorder characterized by recurrent ischemic/hemorrhagic strokes due to progressive occlusion of the intracranial carotid arteries. The lack of reliable disease severity biomarkers led us to investigate molecular features of a Caucasian cohort of MA patients. Methods The participants consisted of 30 MA patients and 40 controls. We measured cerebrospinal fluid (CSF) levels of angiogenic/inflammatory factors (ELISA). We then applied quantitative real‐time PCR on cerebral artery specimens for expression analyses of angiogenic factors. By an immunoassay based on microfluidic technology, we examined the potential correlations between plasma protein expression and MA clinical progression. A RNA interference approach toward Ring Finger Protein 213 (RNF213) and a tube formation assay were applied in cellular model. Results We detected a statistically significant ( p < 0.000001) up‐regulation of Angiopoietin‐2 (Ang‐2) in CSF and stenotic middle cerebral arteries (RQ >2) of MA patients compared to controls. A high Ang‐2 plasma concentration ( p = 0.018) was associated with unfavorable outcome in a subset of MA patients. ROC curve analyses indicated Ang‐2 as diagnostic CSF biomarker (>3741 pg/mL) and prognostic plasma biomarker (>1162 pg/mL), to distinguish stable‐from‐progressive MA. Consistently, MA cellular model showed a significant up‐regulation (RQ >2) of Ang‐2 in RNF213 silenced condition. Interpretation Our results pointed out Ang‐2 as a reliable biomarker mirroring arterial steno‐occlusion and vascular instability of MA in CSF and blood, providing a candidate factor for patient stratification. This pilot study may pave the way to the validation of a biomarker to identify progressive MA patients deserving a specific treatment path.

Angiopoietin

Angiopathy

10.1002/acn3.52076

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Increase of Circulating Endothelial Progenitor Cells and Released Angiogenic Factors in Children with Moyamoya Arteriopathy

International Journal of Molecular Sciences (2023)

Gemma Gorla Tatiana Carrozzini Giuliana Pollaci Antonella Potenza Sara Nava

Moyamoya arteriopathy (MMA) is a rare cerebrovascular disorder that causes recurrent ischemic and hemorrhagic strokes, leading young patients to severe neurological deficits. The pathogenesis of MMA is still unknown. The disease onset in a wide number of pediatric cases raises the question of the role of genetic factors in the disease’s pathogenesis. In these patients, MMA’s clinical course, or progression, is largely unclear. By performing a comprehensive molecular and cellular profile in the plasma and CSF, respectively, of MMA pediatric patients, our study is aimed at assessing the levels of circulating endothelial progenitor cells (cEPC) and the release of selected proteins at an early disease stage to clarify MMA pathogenesis and progression. We employed cytofluorimetric methods and immunoassays in pediatric MMA patients and matched control subjects by age and sex. We detected increased levels of cEPC in peripheral blood and an upregulation of angiogenic markers in CSF (i.e., angiopoietin-2 and VEGF-A). This finding is probably associated with deregulated angiogenesis, as stated by the moderate severity of collateral vessel network development (Suzuki III-IV). The absence of significant modulation of neurofilament light in CSF led us to rule out the presence of substantial neuronal injury in MMA children. Despite the limited cohort of pediatric patients, we found some peculiar cellular and molecular characteristics in their blood and CSF samples. Our findings may be confirmed by wider and perspective studies to identify predictive or prognostic circulating biomarkers and potential therapeutic targets for personalized care of MMA pediatric patients.

Moyamoya Disease

Vasculogenesis

Endothelial progenitor cell

Progenitor

10.3390/ijms24021233

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Citations (1)

Zenodo (CERN European Organization for Nuclear Research) (2022)

Michele Dei Tatiana Carrozzini Giuliana Pollaci Antonella Potenza Sara Nava

DATABASE REPORTING CLINICAL, NEURORADIOLOGICAL, DEMOGRAPHICAL AND BIOLOGICAL (“OMICS”) ANONIMYZED DATA OF A SELECTED SUBGROUP OF PATIENTS AFFECTED BY MOYAMOYA ARTERIOPATHY

Profiling (computer programming)

10.5281/zenodo.5996505

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Multi-Omic Analyses for Biomarker Discovery and Characterization of PNST

Antonella Potenza Tatiana Carrozzini Gemma Gorla Giuliana Pollaci Laura Gatti

Characterization

Biomarker Discovery

10.1007/978-3-031-76382-3_4

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Zenodo (CERN European Organization for Nuclear Research) (2022)

Michele Dei Tatiana Carrozzini Giuliana Pollaci Antonella Potenza Sara Nava

DATABASE REPORTING CLINICAL, NEURORADIOLOGICAL, DEMOGRAPHICAL AND BIOLOGICAL (“OMICS”) ANONIMYZED DATA OF A SELECTED SUBGROUP OF PATIENTS AFFECTED BY MOYAMOYA ARTERIOPATHY

Profiling (computer programming)

Moyamoya Disease

10.5281/zenodo.5940369

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COVID-19 and stroke in women: impact on clinical, psychosocial and research aspects

Neurological Sciences (2024)

Isabella Canavero Benedetta Storti Giulia Marinoni Diana Aguiar De Souza Elena Moro

Pandemic

Stroke

10.1007/s10072-024-07716-0

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The Lipid Asset Is Unbalanced in Peripheral Nerve Sheath Tumors

International Journal of Molecular Sciences (2021)

Ignazio G. Vetrano Michele Dei Vittoria Nazzi Marica Eoli Niccolò Innocenti

Peripheral nerve sheath tumors (PNSTs) include schwannomas, neurofibromas (NFs), and plexiform neurofibromas (PNFs), among others. While they are benign tumors, according to their biological behavior, some have the potential for malignant degeneration, mainly PNFs. The specific factors contributing to the more aggressive behavior of some PNSTs compared to others are not precisely known. Considering that lipid homeostasis plays a crucial role in fibrotic/inflammatory processes and in several cancers, we hypothesized that the lipid asset was also unbalanced in this group of nerve tumors. Through untargeted lipidomics, NFs presented a significant increase in ceramide, phosphatidylcholine, and Vitamin A ester. PNFs displayed a marked decrease in 34 out of 50 lipid class analyzed. An increased level of ether- and oxidized-triacylglycerols was observed; phosphatidylcholines were reduced. After sphingolipidomic analysis, we observed six sphingolipid classes. Ceramide and dihydroceramides were statistically increased in NFs. All the glycosylated species appeared reduced in NFs, but increased in PNFs. Our findings suggested that different subtypes of PNSTs presented a specific modulation in the lipidic profile. The untargeted and targeted lipidomic approaches, which were not applied until now, contribute to better clarifying bioactive lipid roles in PNS natural history to highlight disease molecular features and pathogenesis.

Sphingolipid

Glycosphingolipid

Pathogenesis

10.3390/ijms23010061

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Citations (6)