Nabendu Debnath

Central University of Jammu

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Ashok Kumar Yadav

Krishna Institute of Medical Sciences

Pooja Yadav

Indian Institute of Science Education and Research, Tirupati

Ashwani Kumar

Institute of Microbial Technology

Ashish Tyagi

Texas A&M University

Shalini Arora

Elmhurst Hospital Center

Deepak Kumar

Banaras Hindu University

Ashok Kumar Yadav

Rajiv Gandhi University of Health Sciences

Pooja Yadav

Central University of Jammu

Ashok Kumar Yadav

Rajkiya Engineering College Azamgarh

Vibhav Gautam

Banaras Hindu University

Cooperative Institutions

Bharathidasan University

Vellore Institute of Technology University

Banaras Hindu University

Central University of Haryana

University of Kashmir

Central University of Jammu

i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto

Universidade do Porto

University of Louisville

Ankara University

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Detection of Myeloperoxidase Activity by Enzyme Linked Immunosorbent Assay

Methods and protocols in food science (2022)

Pooja Yadav Nabendu Debnath Ashish Tyagi Ashok Kumar Yadav

Hypochlorous acid

10.1007/978-1-0716-2509-5_38

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Indigenous Probiotic Lactobacillus Strains to Combat Gastric Pathogen Helicobacter pylori: Microbial Interference Therapy

Springer eBooks (2021)

Nabendu Debnath Ashok Kumar Yadav

10.1007/978-981-33-6236-9_9

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The potential link between the development of Alzheimer’s disease and osteoporosis

Biogerontology (2025)

Fariha Nasme Jyotirmaya Behera Prisha Tyagi Nabendu Debnath Jeff C. Falcone

Cognitive Decline

Neuropathology

10.1007/s10522-024-10181-z

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Occurrence, Detection, and Management of T-2 Toxin and HT-2 Toxin in Food and Feed

CRC Press eBooks (2023)

Pooja Yadav Nabendu Debnath Shalini Arora Ashok Kumar Yadav

Fungal species release several secondary metabolites, including plant growth promoters, antibiotics, plant pigments, and several types of toxins. In 1940, the term stachybotryotoxicosis was coined by Soviet scientists to explain a syndrome with symptoms such as pharyngitis, rhinorrhea, hyper-pnea, croak, and pyrexia resulting from expiration of the "Stachybotrys mycotoxin." T-2 toxin affects cereals such as maize, wheat, rice, barley, oats, and soy beans and their by-products and has a deleterious effect on human and animal well-being. T-2 toxin and its metabolites show acute symptoms to humans once ingested. The half-lives of the toxin and its breakdown compounds are usually very short, and they are removed from the body within 48 hours, but it depends on time, amount, and route of exposure. Maximum plasma concentration was reported in rodents. T-2 toxin has a thiol group, which facilitates inhibiting the crucial pathway of protein production by binding with peptidyl transferase enzyme and targets the 60s ribosomal unit, thus hindering translation process.

10.1201/9781003242208-6

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Probiotics as a biotherapeutics for the management and prevention of respiratory tract diseases

Microbiology and Immunology (2022)

Nabendu Debnath Ashwani Kumar Ashok Kumar Yadav

Respiratory diseases are responsible for a greater mortality rate around the world. Viral or bacterial infections in the respiratory tract have been identified as major causative agents for death and disability among the population. Respiratory tract infections (RTIs) cause severe respiratory ailments starting from coldlike symptoms, eventually affecting the lungs and other viscera, and are mainly categorized into two types depending on the affected area: upper RTIs and lower RTIs. Respiratory viruses belong to several viral families such as influenza virus, enterovirus, adenovirus, respiratory syncytial virus, and recently severe acute respiratory syndrome coronavirus 2. Studies have indicated that people with good immune functions are less prone to respiratory infections and also their recovery rate is quicker. Innate and acquired immune systems actively participate in the recognition and elimination of the pathogenic agents. In the present context, the potential of probiotics is recognized as viable microorganisms that support the balance of the beneficial microbial population in the gastrointestinal tract and promote host immunity. The probiotics have long been known to regulate bodily immune functions and have been used against general RTIs such as cough, pharyngitis, laryngitis, pneumonia, and asthma. In addition, intervention with probiotics could directly affect the composition of the gut microbiota that have been shown to palliate respiratory diseases by modulating pulmonary immune activities through the gut-lung axis, and therefore, probiotics could become an alternative therapeutic approach for RTIs.

Respiratory tract

10.1111/1348-0421.12980

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Probiotic Microorganism: A Promising and Innovative Tool for Cancer Prevention and Therapy

Elsevier eBooks (2021)

Nabendu Debnath Ashok Kumar Yadav Ashish Tyagi

Dysbiosis

Cancer Prevention

Human gastrointestinal tract

10.1016/b978-0-12-822909-5.00012-5

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Detection and Management of Ergot Alkaloids and Their Therapeutic Applications

CRC Press eBooks (2023)

Nabendu Debnath Pooja Yadav Shalini Arora Ashok Kumar Yadav

The sclerotia are also broken and combined with flour during milling. Sometimes sclerotia of similar size to the grain are developed in dry climates that are even more difficult to remove. Ergot alkaloids (EAs) are nitrogen-based chemicals that are classified as indole alkaloids. Ergots are a group of metabolites produced by different fungal species. The bio-synthetic pathway of ergot formation involves different genes and proteins, although proteins involved in the ergot synthetic pathway vary according to different fungal species. Ergot ring formation is the shared process in all species. D-lysergic acid is the prime substrate for the formation of ergopeptines catalyzed by an enzymatic complex known as nonribosomal peptide synthetase. Rapid Alert System for Food and Feed recently published a report showing that mycotoxins are still the leading cause of food hazards. In addition to the toxic effects on human populations, animals are equally affected due to EA contamination.

10.1201/9781003242208-7

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Assessment of Probiotic and Antioxidant Potential of Indigenous Lactobacillus Strains Isolated from Human Faecal Samples

Indian Journal of Microbiology (2023)

Nabendu Debnath Pooja Yadav Ashok Kumar Yadav

ABTS

Lactobacillus fermentum

10.1007/s12088-023-01129-x

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Advanced diagnostic methods for identification of bacterial foodborne pathogens: contemporary and upcoming challenges

Critical Reviews in Biotechnology (2022)

Surbhi Panwar K. Siddaardha Duggirala Pooja Yadav Nabendu Debnath Ashok Kumar Yadav

It is a public health imperative to have safe food and water across the population. Foodborne infections are one of the primary causes of sickness and mortality in both developed and developing countries. An estimated 100 million foodborne diseases and 120 000 foodborne illness-related fatalities occur each year in India. Several factors affect foodborne illness, such as improper farming methods, poor sanitary and hygienic conditions at all levels of the food supply chain, the lack of preventative measures in the food processing industry, the misuse of food additives, as well as improper storage and handling. In addition, chemical and microbiological combinations also play a key role in disease development. But recent disease outbreaks indicated that microbial pathogens played a major role in the development of foodborne diseases. Therefore, prompt, rapid, and accurate detection of high-risk food pathogens is extremely vital to warrant the safety of the food items. Conventional approaches for identifying foodborne pathogens are labor-intensive and cumbersome. As a result, a range of technologies for the rapid detection of foodborne bacterial pathogens have been developed. Presently, many methods are available for the instantaneous detection, identification, and monitoring of foodborne pathogens, such as nucleic acid-based methods, biosensor-based methods, and immunological-based methods. The goal of this review is to provide a complete evaluation of several existing and emerging strategies for detecting food-borne pathogens. Furthermore, this review outlines innovative methodologies and their uses in food testing, along with their existing limits and future possibilities in the detection of live pathogens in food.

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Food microbiology

10.1080/07388551.2022.2095253

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In Vivo Evaluation of Adhesion Properties of Probiotics

Methods and protocols in food science (2022)

Nabendu Debnath Pooja Yadav Ashish Tyagi Ashok Kumar Yadav

Intestinal epithelium

Intestinal mucosa

10.1007/978-1-0716-2509-5_29

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