Min‐Yen Hsu

Chung Shan Medical University Hospital

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Chao‐Min Cheng

National Tsing Hua University

Connie Chen

Chung Shan Medical University Hospital

Chihchen Chen

National Tsing Hua University

Shang-Chi Lin

Shanghai Jiao Tong University

Chun-Yuan Wang

Taichung Veterans General Hospital

Keng‐Hung Lin

Taichung Veterans General Hospital

Fan‐Gang Tseng

National Tsing Hua University

Shih‐Jen Chen

National Yang Ming Chiao Tung University

Jyh-Cheng Liou

Chung Shan Medical University

Li-Chen Wei

Taichung Veterans General Hospital

Cooperative Institutions

Chung Shan Medical University

National Yang Ming Chiao Tung University

Taichung Veterans General Hospital

China Medical University

Chung Shan Medical University Hospital

National Taiwan University

China Medical University Hospital

National Tsing Hua University

National Chung Hsing University

China Medical University

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

Comprehensive study on the reliability of IGBT module bonding process on the surface microstructure of heat dissipation substrate

H.K Hsieh Yang Lu Min‐Yen Hsu Chun-Jui Huang Meiyan Pan

Organic and metal substrates are used in the circuit boards of low-power home appliances and computers. However, for high-voltage, high-current applications like, power modules, solar inverters and motor controllers, ceramic substrate materials such as alumina, aluminum nitride and silicon nitride with better thermal properties are needed. In this study, we investigate the effect of the microstructures and surface roughness of the Cu surface on the Si3N4-active metal braze (AMB) ceramic/metal components substrate are carried out respectively by optical microscope (OM), scanning electron microscope (SEM) and 3D optical profilometer. In this way, the influence of substrate roughness with different physical and chemical surface treatment could be understood better. On the other hand, we also study the wire pull testing as well as the bond adhesion of surface roughness by varying surface treatment of the Cu. This study can help us understand how the confinement influences the properties of Cu at a constant value of surface roughness ranging from 0.3 to 0.45um. Thus, this article investigates the influence of surface roughness and morphologic effects of silicon nitride active metal brazing substrates following different surface treatments.

Brazing

10.1109/impact59481.2023.10348908

Cite

Citations (0)

Monitoring VEGF levels with low-volume sampling in major vision-threatening diseases: age-related macular degeneration and diabetic retinopathy

Lab on a Chip (2015)

Min‐Yen Hsu Shih‐Jen Chen Kuan‐Hung Chen Yu‐Chien Hung Hin-Yeung Tsai

The purpose of this article is to demonstrate the capacity of paper-based ELISA (P-ELISA) to monitor VEGF in patients requiring treatment for vision-threatening diseases.

10.1039/c4lc01052c

Cite

Citations (28)

Contents Vol. 57, 2017

Ophthalmic Research (2017)

Ching-Yu Wang Chiao-Ying Liang Shih-Chao Feng Keng-Hung Lin Hsin-Nung Lee

10.1159/000475485

Cite

Citations (0)

A 2-Years Comparative Analysis of Tirzepatide, Semaglutide, Qsymia, Contrave, and Phentermine on Ocular Health in Individuals with Obesity: A Propensity-Score Matched Cohort Study

Research Square (Research Square) (2025)

Pen‐Hua Su Yu‐Nan Huang Jo-Ching Chen Pin-Hung Li Min‐Yen Hsu

Abstract This landmark propensity-score matched study examined ocular outcomes of modern anti-obesity medications in nearly 5 million non-diabetic individuals with obesity. Through analysis of TriNetX US network data, we discovered that Tirzepatide significantly reduced cataract risk versus other treatments, showing a striking 59% lower risk compared to Semaglutide (HR: 0.41, 95% CI: 0.19–0.85). Semaglutide users experienced markedly fewer visual disturbances than those on Contrave (HR: 0.58, 95% CI: 0.41–0.82) or Phentermine (HR: 0.62, 95% CI: 0.46–0.82). Both GLP-1 receptor agonists demonstrated protection against age-related cataracts, with Tirzepatide showing exceptional benefits versus Contrave (HR: 0.17, 95% CI: 0.07–0.42). While these protective effects remained robust across patient subgroups, Tirzepatide's benefits diminished in those with impaired kidney function. Multiple sensitivity analyses and negative controls validated these compelling findings.

Phentermine

Semaglutide

10.21203/rs.3.rs-5493930/v1

Cite

Citations (0)

Treat Venous Air Embolism Induced Acute Hypoxemic Respiratory Failure during Retinal Surgery by ECMO (V-V Mode).

Zhōnghuá mínguó xīnzàngxué huì zázhì (2021)

Chung-Ting Kuo Yih Yang Shou-Ho Tseng Min‐Yen Hsu Nien-Yi Wu

Acute respiratory failure

10.6515/acs.202103_37(2).20201224a

Cite

Citations (4)

Soft peripheral contact lens for eye elongation control (SPACE): 1-year results of a double-blinded randomized controlled trial

Contact Lens and Anterior Eye (2024)

S.–M. Lee Min‐Yen Hsu Shih-Chien Huang Connie Chen

Double blinded

Elongation

10.1016/j.clae.2024.102256

Cite

Citations (0)

Impact of the Severities of Glaucoma on the Incidence of Subsequent Dementia: A Population-Based Cohort Study

International Journal of Environmental Research and Public Health (2020)

Fu-Hsuan Kuo Jui-Fu Chung Min‐Yen Hsu Chia‐Yi Lee Jing‐Yang Huang

The aim of the present study was to survey the relationship between the severity of glaucoma and subsequent dementia using the National Health Insurance Research Database (NHIRD) in Taiwan. Subjects with glaucoma were selected into the study group after an exclusion process, and each subject in the study group was propensity score-matched to another non-glaucoma patient that constituted the control group. The Cox proportional hazard regression that considered multiple potential risk factors of dementia was used to yield the adjusted hazard ratios (aHR) of dementia in different severities of glaucoma. There were 1185 (5.63 percent) subjects in the study group and 1119 (5.32 percent) patients in the control group that developed dementia. After adjusting for multiple confounders, there were no differences in the rate of any dementia (aHR: 0.961, 95% CI: 0.886–1.043, p = 0.3443), vascular dementia (aHR: 0.928, 95% CI: 0.846–1.018, p = 0.1154), Alzheimer’s disease (aHR: 1.018, 95% CI: 0.761–1.362, p = 0.9025) or Parkinson’s disease (aHR: 1.021, 95% CI: 0.886–1.176, p = 0.7744) between the study and the control groups. Regarding the disease severity of glaucoma, no difference was found in any type of dementia whether the glaucoma patients received less than two medical treatments, received more than two medical treatments, received drainage surgeries or received destructive surgeries. In conclusion, the different severities of glaucoma do not alter the incidence of subsequent dementia.

10.3390/ijerph17072426

Cite

Citations (13)

Differences in the Quantity and Composition of Extracellular Vesicles in the Aqueous Humor of Patients with Retinal Neovascular Diseases

Diagnostics (2021)

Yai-Ping Hsiao Connie Chen Chee-Ming Lee Peiying Chen Wei-Heng Chung

Extracellular vesicles (EVs) are secreted by various cells in the body fluid system and have been found to influence vessel formation and inflammatory responses in a variety of diseases. However, which EVs and their subtypes are involved in vascular retinal diseases is still unclear. Therefore, the aim of this study was to explore the particle distribution of EVs in retinal neovascular diseases, including age-related macular degeneration, polypoidal choroidal vasculopathy, and central retinal vein occlusion. The aqueous humor was harvested from 20 patients with different retinal neovascular diseases and six patients with cataracts as the control group. The particle distribution was analyzed using nanoparticle tracking analysis (NTA) and transmitting electron microscopy (TEM). The results revealed that the disease groups had large amounts of EVs and their subtypes compared to the control group. After isolating exosomes, a higher expression of CD81+ exosomes was shown in the disease groups using flow cytometry. The exosomes were then further classified into three subtypes of exomeres, small exosomes, and large exosomes, and their amounts were shown to differ depending on the disease type. To the best of our knowledge, this is the first study to elucidate the dynamics of EVs in retinal neovascular diseases using clinical cases. Our findings demonstrated the possible functionality of microvesicles and exosomes, indicating the potential of exosomes in the diagnosis and therapy of retinal neovascular diseases.

Nanoparticle tracking analysis

10.3390/diagnostics11071276

Cite

Citations (20)

Protective Effect of Quercetin on Sodium Iodate-Induced Retinal Apoptosis through the Reactive Oxygen Species-Mediated Mitochondrion-Dependent Pathway

International Journal of Molecular Sciences (2021)

Yuan‐Yen Chang Yi‐Ju Lee Min‐Yen Hsu Meilin Wang Shang‐Chun Tsou

Age-related macular degeneration (AMD) leads to gradual central vision loss and is the third leading cause of irreversible blindness worldwide. The underlying mechanisms for this progressive neurodegenerative disease remain unclear and there is currently no preventive treatment for dry AMD. Sodium iodate (NaIO3) has been reported to induce AMD-like retinal pathology in mice. We established a mouse model for AMD to evaluate the effects of quercetin on NaIO3-induced retinal apoptosis, and to investigate the pertinent underlying mechanisms. Our in vitro results indicated that quercetin protected human retinal pigment epithelium (ARPE-19) cells from NaIO3-induced apoptosis by inhibiting reactive oxygen species production and loss of mitochondrial membrane potential as detected by Annexin V-FITC/PI flow cytometry. We also evaluated the relative expression of proteins in the apoptosis pathway. Quercetin downregulated the protein expressions of Bax, cleaved caspase-3, and cleaved PARP and upregulated the expression of Bcl-2 through reduced PI3K and pAKT expressions. Furthermore, our in vivo results indicated that quercetin improved retinal deformation and increased the thickness of both the outer nuclear layer and inner nuclear layer, whereas the expression of caspase-3 was inhibited. Taken together, these results demonstrate that quercetin could protect retinal pigment epithelium and the retina from NaIO3-induced cell apoptosis via reactive oxygen species-mediated mitochondrial dysfunction, involving the PI3K/AKT signaling pathway. This suggests that quercetin has the potential to prevent and delay AMD and other retinal diseases involving NaIO3-mediated apoptosis.

Outer nuclear layer

10.3390/ijms22084056

Cite

Citations (28)

Risk of developing open-angle glaucoma in patients with carotid artery stenosis: A nationwide cohort study

PLoS ONE (2018)

Chien-Chih Chou Min‐Yen Hsu Ching‐Heng Lin Che‐Chen Lin Chun-Yuan Wang

Whether carotid artery stenosis (CAS) is an independent risk factor for open-angle glaucoma remains unclear. In this study, we investigated the association between CAS and the development of open-angle glaucoma in the Taiwanese population-based cohort derived from a longitudinal database containing claims data from the Taiwan National Health Insurance (NHI) program; this study enrolled 2093 patients with CAS and 8372 patients without CAS matched by age and sex from 1999 to 2010. Diagnoses of open-angle glaucoma (OAG) were identified during a follow-up period lasting through December 31, 2013. A Cox proportional hazards model was applied to evaluate the hazard ratio (HR) for OAG in the CAS cohort compared with the matched cohort. We found that the HR for open-angle glaucoma in the CAS cohort compared with the matched cohort. The adjusted HR for OAG in the CAS cohort was 1.50 (95% confidence interval, 1.11-2.02, P = .008). The Kaplan-Meier analysis revealed that the CAS cohort had a higher cumulative incidence of OAG than did the matched cohort during the follow-up period (log-rank test, P < .001). We concluded that CAS is a significantly independent risk factor for the development of OAG. Our finding is clinically important for the aging population, which has an increasing prevalence of CAS.

10.1371/journal.pone.0194533

Cite

Citations (10)