Eropkin MIu

Research Institute of Influenza

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Daria Danilenko

Research Institute of Influenza

НИ

Н. И. Коновалова

Research Institute of Influenza

ЕМ

Е. М. Еропкина

Research Institute of Influenza

P. A. Petrova

Moscow State University

Kiselëv Oi

Research Institute of Influenza

Maria Pisareva

Research Institute of Influenza

Eropkina Em

Russian Scientific Research Institute of Traumatology and Orthopedics named after R.R. Vreden

Grudinin Mp

Research Institute of Influenza

Gudkova Tm

АА

А. А. Соминина

Research Institute of Influenza

Cooperative Institutions

Research Institute of Influenza

Ministry of Health of the Russian Federation

Russian Academy of Sciences

Academy of Medical Sciences

Institute of Macromolecular Compounds

Erasmus MC

Institute of Virology of the Slovak Academy of Sciences

St Petersburg University

Erasmus University Rotterdam

Peter the Great St. Petersburg Polytechnic University

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Synthesis and antiviral activity of novel glycyrrhizic acid conjugates with D-amino acid esters

Russian Journal of Bioorganic Chemistry (2017)

A. I. Fayrushina Л. А. Балтина Л. А. Балтина Н. И. Коновалова P. A. Petrova

Bioorganic chemistry

Conjugate

10.1134/s1068162017040045

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Citations (12)

Peptide fibrils as vaccine: a proof of concept

bioRxiv (Cold Spring Harbor Laboratory) (2023)

Yana Zabrodskaya К. В. Сивак Maria V. Sergeeva А. Г. Александров Elena Kalinina

The potential of amyloid-like fibrils formed by peptides as vaccine candidates was investigated using a fragment of the Ebola virus glycoprotein. Peptide in fibrillar form were found to induce an immune response to the full-length protein without causing cellular toxicity or significant changes in hematological studies. The ability of the studied peptide fragment to oligomerize and form amyloid-like fibrils and intermediates suggests potential implications for the virus's mechanisms of action on cells, particularly those of the immune system. Additionally, if native GP2 epitopes are retained in the peptide fibrils, they may serve as effective immunization agents due to their autoadjuvant properties; however, it is important to consider the possibility of cross-reactivity with human proteins. These findings provide valuable insights into the potential use of amyloid-forming peptide as vaccine candidates and highlight the need for further research into their immunogenic and adjuvant properties.

Peptide vaccine

Amyloid (mycology)

10.1101/2023.12.30.573725

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Synthesis of Conjugates of Lupane-Type Pentacyclic Triterpenoids with 2-Aminoethane- and N-Methyl-2-Aminoethanesulfonic Acids. Assessment of in vitro Toxicity

Chemistry of Natural Compounds (2017)

N. G. Komissarova S. N. Dubovitskii О. В. Шитикова Е. М. Вырыпаев Л. В. Спирихин

Betulin

Betulinic acid

Linker

Conjugate

10.1007/s10600-017-2153-6

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Citations (9)

Physicochemical, molecular, and biological properties of complexes formed between aminoglycoside antibiotics and some anionic copolymers of acrylic series: Part II

Journal of Bioactive and Compatible Polymers (2015)

Е. Б. Тарабукина М. В. Соловский V. D. Pautov Alina Amirova Н. В. Захарова

Physicochemical and molecular properties of complexes formed by aminoglycoside antibiotics, including neomycin, gentamicin, kanamycin, and amikacin, in the form of bases and carboxyl- or sulfo-comprising copolymers of acrylamide or N-(2-hydroxypropyl)methacrylamide have been studied. The toxicity of complexes in vitro and their antimicrobial activity are matched to their behavior in solutions. Direct dependency of toxic and antibacterial properties of polymer complexes of aminoglycoside antibiotics on their molecular characteristics and stability opens up perspectives of targeting control over their antimicrobial activity by changing the microstructure of their polymer carrier chains.

Methacrylamide

Amikacin

Kanamycin

10.1177/0883911515592258

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Citations (6)

[Development of influenza surveillance in Russia in the system of the WHO national influenza center].

PubMed (2013)

Sominina Aa Grudinin Mp Eropkin MIu Elizaveta Smorodintseva Maria Pisareva

Analysis of development influenza activity season 2010-2011 is presented. Significant participation of influenza A(H1N1)pdm09 virus and influenza B of Victoria lineage virus in the epidemic morbidity structure with minor participation ofA(H3N2) virus was revealed. The influenza viruses isolated in Russia according to antigenic properties were similar to the strains included in the vaccine composition. Drift variants of influenza A(H1N1)pdm09 viruses isolated in Astrakhan and St.-Petersburg were recognized using WHO CC in London as representatives of three new genetic groups.

Human influenza

Lineage (genetic)

H5N1 genetic structure

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Biological Effects in Cell Cultures of Fullerene C60: Dependence on Aggregation State

Carbon materials: chemistry and physics/Carbon materials (2008)

L. B. Piotrovsky Eropkin MIu Е. М. Еропкина М. А. Думпис О. И. Киселев

Polyvinylpyrrolidone

Viability assay

10.1007/978-1-4020-6845-4_7

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Citations (6)

Cytotoxicity and Antibacterial Activity of Protonated Diallylammonium Polymers: Influence of End Groups and Molecular Weight

International Journal of Molecular Sciences (2025)

L. М. Timofeeva Yulia A. Simonova Ivan V. Eremenko М. П. Филатова Maxim A. Topchiy

A series of antimicrobial protonated diallylammonium polymers, poly(diallylammonium trifluoroacetate) (PDAATFA), were synthesized by classical polymerization, using an especially elaborated method for preparation of polymers with low molecular weight (MW), and by RAFT polymerization, with different end groups in a range of MW values of (8–43) × 103 g∙mol−1. Cytotoxicity relative to eukaryotic cells (epithelioid lines A-549 and MA-104) and bactericidal activity of the polymers (relative to Pseudomonas aeruginosa and Staphylococcus aureus) are investigated. The effect of the end groups and MW on toxicity and bactericidal activity is shown. Dependence of the activity and, most of all, cytotoxicity on MW is preserved even at a small difference in MW values in the MW range of (18–40) × 103 g·mol−1. A clear dependence of the studied properties on the nature of the terminal group is revealed. Sulfate -O-S(=O)2-O¯ end group has a noticeable effect on the bactericidal efficiency and smaller influence on toxicity, while dithiocarbonyl end group -S-C(=S)-O-CH2-CH3 has a significant effect on efficiency and especially toxicity, drastically increasing the latter. Overall, based on the results obtained, polymers PDAATFA of low MW are considered promising antimicrobial agents for the creation of new transdermal drugs.

Molecular mass

10.3390/ijms26041501

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Полимерные комплексы антибиотика рифампицина на основе поли-2-акриламидо-2-метилпропансульфокислоты

Химико-фармацевтический журнал (2022)

Михаил В. Соловский Максим С. Борисенко Марианна Ю. Смирнова Eropkin MIu Елена М. Еропкина

10.30906/0023-1134-2022-56-8-17-20

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Two years of experience in hospital surveillance for the severe influenza like illnesses in St. Petersburg: etiology, clinical characterization of diseases, antigenic and genetic properties of isolated influenza viruses

Microbiology Independent Research Journal (MIR Journal) (2015)

А. А. Соминина Maria Pisareva Grudinin Mp Eropkin MIu Н. И. Коновалова

ABSTRACT In this paper, we analyze the etiology of the diseases occurring during two consecutive influenza epidemic seasons in St. Petersburg, Russian Federation. The analysis is based on the results of the PCR diagnostics of the clinical samples collected from patients hospitalized in three St. Petersburg hospitals with influenza like illnesses (ILI). It was shown that the influenza virus A(H1N1)pdm09 was the dominant causative agent during the 2012-2013 epidemic season while, in the 2013-2014 season, A(H3N2) virus was predominant among adults and children. The influenza B virus activity was high in the 2012-2013 season and low in the 2013-2014 season. During both seasons, the main causative agent for the hospitalization of young children was respiratory syncytial virus (RSV), followed by rhinovirus and influenza virus. The rate of involvement of parainfluenza, adenovirus, metapneumovirus and coronavirus was low and was negligible for bocavirus. Children 0-2 and 3-6 years old formed the group of patients that was affected by acute respiratory infection agents the most. Children younger than 3 months old were the major group of the intensive care unit (ICUs) patients and only 27.5% of them were adults. RSV and rhinovirus were the leading cause of ILI among the children admitted to ICU. Among the adult patients admitted to the ICU, only influenza A(H1N1)pdm09, A(H3N2) and B viruses were detected during both influenza seasons. According to the results of the antigenic and genetic analysis, most influenza A(H1N1)pdm09 and A(H3N2) viruses circulating in St. Petersburg matched the vaccine strains recommended by the WHO for vaccine composition in the 2012-2013 and 2013-2014 seasons.

Rhinovirus

Etiology

10.18527/2500-2236-2015-2-1-44-55

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Citations (1)

H1N1V influenza epidemic of 2009 in Russia

Л. М. Цыбалова Karpova Ls Komissarov Ab Eropkin MIu Grudinin Mp

The paper describes dynamics, distribution and morbidity rate during the 2009 A(H1N1)v influenza epidemic in Russia. The epidemic appears to have been especially severe in the cities of the Far-East and Siberian Federal Districts where the average morbidity rate ranged from 6.4% to 19.2% (mean 10.3%) and the epidemic duration from 7.8 to 8 weeks. In less affected Southern and Central Federal Districts A(H1N1)v influenza occurred in 5.7% of the population. Schoolchildren aged 7-4 years showed the highest morbidity rate of 28.8%. The age group of 18-53 years accounted for 79.4% of the total lethality. Viral isolates were genetically stable and exhibited 98.9% hemagglutnin (HA) homology with reference viruses. None of the strains had an amino acid substitution at position 275 of neuraminidase (NA) responsible for resistance to oseltamivir. Towards the end of the epidemic, the viral population displayed a significant rise in the number of strains containing mutations in 4 genes (4 HA, 2 NA, 2 PB2 and 1 PA mutations respectively). 26.7% of the viral isolates obtained in the end of the epidemic had D222G substitution responsible for tropism of viruses to lung tissues. Epidemiologically, the 2009 A(H1NI)v influenza epidemic is described as moderate based on the absence of pathogenicity determinants typical of both A(H1N1) influenza virus of 1918 and A(H5N1) virus. The paper compares the 2009 epidemic with those caused by A/Honkong/68 and A/USSR/ 90/77 viruses. The necessity of classification for the discrimination between A(H1N1) subtype viruses is emphasized.

Oseltamivir

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