Katie Williams

The Ohio State University

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Rosa Lapalombella

The Ohio State University

John C. Byrd

The Ohio State University

James S. Blachly

The Ohio State University

Larry Beaver

The Ohio State University

Lindsey T. Brinton

University of Virginia

Lapo Alinari

The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute

Steven Sher

The Ohio State University

Deepa Sampath

The University of Texas MD Anderson Cancer Center

Amy M. Lehman

Exact Sciences (United States)

Shaneice Mitchell

Stanford University

Cooperative Institutions

The Ohio State University

176

The Ohio State University Wexner Medical Center

The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute

Ohio University

University of Waterloo

Ottawa Hospital Research Institute

Ottawa Hospital

University of Toronto

Plexxikon (United States)

Comprehensive Blood & Cancer Center

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Katie Williams

Welsh

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Supplementary Figure S3 from Targeting DNA Damage Repair Functions of Two Histone Deacetylases, HDAC8 and SIRT6, Sensitizes Acute Myeloid Leukemia to NAMPT Inhibition

Pu Zhang Lindsey T. Brinton Katie Williams Steven Sher Shelley Orwick

<p>Combined treatment of AR-42 and KPT-9274 leads to mitochondrial potential collapses in cell lines.</p>

DNA Damage Repair

HDAC8

SIRT6

10.1158/1078-0432.22484252.v1

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Contributors

Elsevier eBooks (2020)

Courtney Babb Joana Barros Michael G.H. Bell Madiha Bencekri Geneviève Boisjoly

10.1016/b978-0-12-819822-3.09988-0

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Adapting to Climate Change in the Compact City: The Suburban Challenge

Built Environment (2010)

Katie Williams Jennifer Joynt Diane Hopkins

This paper sets out the challenges of adapting suburbs for climate change in the context of the compact city agenda. We argue that while the compact city debate does address mitigating climate change at a strategic level, it does not specifically consider adapting existing suburban areas to cope with anticipated changes. We discuss the possibilities for, and challenges of, suburban adaptation. In terms of the built environment, such challenges include: difficulties retrofitting existing housing stock, the fragmented ownership and management of land and housing, and the slow pace of change in suburban areas. In terms of mobilizing social change to affect adaptation, problems of coordinating multi-actor partnerships, developing political will, generating public acceptance, and encouraging behaviour change are identified. We conclude that suburbs pose unique challenges for realizing transformations, and that the 'sustainable development' and 'climate change' discourses have yet to be fully integrated in the light of potential conflicts between mitigation and adaptation measures.

Compact city

10.2148/benv.36.1.105

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Citations (39)

Microfinance-Invest in a Life

Katie Williams

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Epigenetic changes during disease progression in a murine model of human chronic lymphocytic leukemia

Proceedings of the National Academy of Sciences (2009)

Shih‐Shih Chen Aparna Raval Amy J. Johnson Erin Hertlein Te-Hui Liu

Epigenetic alterations, including gain or loss of DNA methylation, are a hallmark of nearly every malignancy. Changes in DNA methylation can impact expression of cancer-related genes including apoptosis regulators and tumor suppressors. Because such epigenetic changes are reversible, they are being aggressively investigated as potential therapeutic targets. Here we use the Emu-TCL1 transgenic mouse model of chronic lymphocytic leukemia (CLL) to determine the timing and patterns of aberrant DNA methylation, and to investigate the mechanisms that lead to aberrant DNA methylation. We show that CLL cells from Emu-TCL1 mice at various stages recapitulate epigenetic alterations seen in human CLL. Aberrant methylation of promoter sequences is observed as early as 3 months of age in these animals, well before disease onset. Abnormally methylated promoter regions include binding sites for the transcription factor FOXD3. We show that loss of Foxd3 expression due to an NF-kappaB p50/p50:HDAC1 repressor complex occurs in TCL1-positive B cells before methylation. Therefore, specific transcriptional repression is an early event leading to epigenetic silencing of target genes in murine and human CLL. These results provide strong rationale for the development of strategies to target NF-kappaB components in CLL and potentially other B-cell malignancies.

10.1073/pnas.0906455106

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Citations (84)

Rare t(X;14)(q28;q32) translocation reveals link between MTCP1 and chronic lymphocytic leukemia

RePEc: Research Papers in Economics (2021)

Janek S. Walker Zachary A. Hing Steven Sher J. Cronin Katie Williams

Link (geometry)

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Evaluative application of UKCP09‐based downscaled future weather years to simulate overheating risk in typical English homes

Structural Survey (2013)

Rajat Gupta Matthew Gregg Hu Du Katie Williams

Purpose To critically compare three future weather year (FWY) downscaling approaches, based on the 2009 UK Climate Projections, used for climate change impact and adaptation analysis in building simulation software. Design/methodology/approach The validity of these FWYs is assessed through dynamic building simulation modelling to project future overheating risk in typical English homes in 2050s and 2080s. Findings The modelling results show that the variation in overheating projections is far too significant to consider the tested FWY data sets equally suitable for the task. Research and practical implications It is recommended that future research should consider harmonisation of the downscaling approaches so as to generate a unified data set of FWYs to be used for a given location and climate projection. If FWY are to be used in practice, live projects will need viable and reliable FWY on which to base their adaptation decisions. The difference between the data sets tested could potentially lead to different adaptation priorities specifically with regard to time series and adaptation phasing through the life of a building. Originality/value The paper investigates the different results derived from FWY application to building simulation. The outcome and implications are important considerations for research and practice involved in FWY data use in building simulation intended for climate change adaptation modelling.

Overheating (electricity)

10.1108/ss-01-2013-0005

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Citations (2)

Does shared outdoor space contribute to neighbourliness

Morag Lindsay Katie Williams

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Supplementary Methods from Targeting DNA Damage Repair Functions of Two Histone Deacetylases, HDAC8 and SIRT6, Sensitizes Acute Myeloid Leukemia to NAMPT Inhibition

Pu Zhang Lindsey T. Brinton Katie Williams Steven Sher Shelley Orwick

<p>Supplementary Methods</p>