Anoma Somasunderam

The University of Texas Health Science Center at Houston

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Co-Authors

David G. Gorenstein

The University of Texas Health Science Center at Houston

Netanya S. Utay

The University of Texas Southwestern Medical Center

Varatharasa Thiviyanathan

The University of Texas Health Science Center at Houston

David E. Volk

Robert Bosch (Germany)

Takemi Tanaka

University of Oklahoma Health Sciences Center

Ronald Grigg

University of Wisconsin–Madison

Jordan E. Lake

The University of Texas Health Science Center at Houston

Roberto C. Arduino

The University of Texas Health Science Center at Houston

David M. Asmuth

University of California, Davis

Aman P. Mann

Northwell Health

Cooperative Institutions

The University of Texas Health Science Center at Houston

The University of Texas MD Anderson Cancer Center

The University of Texas Medical Branch at Galveston

Baylor College of Medicine

University of California, San Francisco

The University of Texas at Austin

National Institutes of Health

Johns Hopkins University

University of California, San Diego

Office of Infectious Diseases

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ChemInform Abstract: Synthesis of Unsaturated Acids by 1,2‐Addition of Formic Acid to Conjugated Dienes Catalyzed by Palladium on Carbon in the Presence of Mono and Bidentate Phosphines.

ChemInform (1995)

G. Vasapollo Anoma Somasunderam Bassam El Ali Howard Alper

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

Carbon fibers

10.1002/chin.199502066

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Citations (0)

E‐Selectin‐Targeted Porous Silicon Particle for Nanoparticle Delivery to the Bone Marrow

Advanced Materials (2011)

Aman P. Mann Takemi Tanaka Anoma Somasunderam Xuewu Liu David G. Gorenstein

A multifunctional drug delivery system is developed comprising biodegradable porous silicon microparticles that act as motherships to ferry different types of imaging and therapeutic nanoparticles loaded within their porous structure. An E-selectin thioaptamer ligand is used to actively target this delivery system to the bone marrow vasculature where the payload is released as the porous silicon underwent degradation under physiological conditions. Detailed facts of importance to specialist readers are published as "Supporting Information". Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.

Porous Silicon

Payload (computing)

Particle (ecology)

Targeted drug delivery

10.1002/adma.201101541

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Citations (126)

X-Aptamers: A Bead-Based Selection Method for Random Incorporation of Druglike Moieties onto Next-Generation Aptamers for Enhanced Binding

Biochemistry (2012)

Weiguo He Miguel-Angel Elizondo-Riojas Xin Li Ganesh Lakshmana Rao Lokesh Anoma Somasunderam

By combining pseudorandom bead-based aptamer libraries with conjugation chemistry, we have created next-generation aptamers, X-aptamers (XAs). Several X-ligands can be added in a directed or random fashion to the aptamers to further enhance their binding affinities for the target proteins. Here we describe the addition of a drug (N-acetyl-2,3-dehydro-2-deoxyneuraminic acid), demonstrated to bind to CD44-HABD, to a complete monothioate backbone-substituted aptamer to increase its binding affinity for the target protein by up to 23-fold, while increasing the drug's level of binding 1-million fold.

Aptamer

Binding affinities

Target protein

SELEX Aptamer Technique

10.1021/bi300471d

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Citations (66)

Metabolism and fate of xenoestrogens in man

Pure and Applied Chemistry (1998)

Joachim G. Liehr Anoma Somasunderam Deepali Rahi Roy

Abstract

10.1351/pac199870091747

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Citations (14)

Evaluation of Six Weekly Oral Fecal Microbiota Transplants in People with HIV

Pathogens and Immunity (2020)

Netanya S. Utay Ana Monczor Anoma Somasunderam Sofia Lupo Zhi‐Dong Jiang

Background: Reduced microbiota diversity (dysbiosis) in people with HIV (PWH) likely contributes to inflammation, a driver of morbidity and mortality. We aimed to evaluate the safety and tolerability of 6 weekly oral fecal microbiota transplants (FMT) administered to reverse this dysbiosis.Methods: Six PWH on suppressive antiretroviral therapy (ART) received 6 weekly doses of lyophilized fecal microbiota product from healthy donors. Shotgun sequencing on stool before, after last FMT, and 20 weeks thereafter was performed. Inflammation and gut permeability biomarkers were measured.Results: Median age at week 0 was 39 years, CD4+ T cell count 496 cells/mm3, HIV RNA levels <20 copies/mL. FMT was safe and well-tolerated. Alpha diversity increased in 4 participants from weeks 0 to 6, including the 3 with the lowest alpha diversity at week 0. At week 26, alpha diversity more closely resembled week 0 than week 6 in these 4 participants. Metagenomic analysis showed no consistent changes across all participants. One participant had high gut permeability and inflammation biomarker levels and low alpha diversity that improved between weeks 0 and 6 with a shift in distribution.Conclusions: Weekly FMT was safe and well-tolerated. Alpha diversity increased in participants with the lowest baseline alpha diversity during the treatment period. Future randomized, controlled trials of FMT should consider evaluating PWH with greater inflammation, gut damage, or dysbiosis as this population may be most likely to show a significant response.ClinicalTrials.gov Identifier: NCT03329560

Dysbiosis

Tolerability

10.20411/pai.v5i1.388

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Citations (18)

Solution Structure of 8OG:G mismatch containing duplex

Varatharasa Thiviyanathan Anoma Somasunderam Tapas K. Hazra Susil K. Mitra David G. Gorenstein

Duplex (building)

10.2210/pdb1n2w/pdb

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X = Y - ZH systems as potential 1,3-dipoles. Part 40. Chiral azomethine ylides from homochiral cyclic α-amino esters. Unusual regiospecific deprotonation of iminium ions.

Tetrahedron (1993)

Ronald Grigg Zoran Ranković Mark Thornton‐Pett Anoma Somasunderam

Iminium

Stereospecificity

10.1016/s0040-4020(01)96273-8

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Citations (24)

Combinatorial selection and delivery of thioaptamers

Biochemical Society Transactions (2007)

Varatharasa Thiviyanathan Anoma Somasunderam David G. Gorenstein

Oligonucleotide-based agents are emerging as potential therapeutic agents that can be attractive alternatives for the small-molecule chemical drugs. Monothiophosphate-backbone-modified DNA aptamers (thioaptamers) that specifically and tightly bind to the RNase H domain of the HIV RT (reverse transcriptase) have been isolated from nucleic acid libraries using combinatorial selection methods. The selected thioaptamer inhibited RNase H activity of the HIV RT in in vitro studies. In cell cultures, the transfected thioaptamer markedly reduced HIV production in a dose-dependent manner. Gel electrophoretic mobility-shift assays and NMR spectroscopy showed that the selected thioaptamer binds to the isolated RNase H domain, but did not bind to a structurally similar RNase H from Escherichia coli. In cell cultures, the transfected thioaptamer showed a dose-dependent inhibition of HIV replication, with a maximal inhibition of 83%. Using various liposome-delivery agents, the DNA thioaptamer was transfected into HIV-infected astrocytoma adherent cells with greater than 70% efficiency.

RNase H

10.1042/bst0350050

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Citations (22)

Unchanged Levels of Soluble CD14 and IL-6 Over Time Predict Serious Non-AIDS Events in HIV-1-Infected People

AIDS Research and Human Retroviruses (2016)

Meena Sunil Maitreyee Nigalye Anoma Somasunderam María Laura Martínez Xiaoying Yu

HIV-1-infected persons have increased risk of serious non-AIDS events (SNAEs) despite suppressive antiretroviral therapy. Increased circulating levels of soluble CD14 (sCD14), soluble CD163 (sCD163), and interleukin-6 (IL-6) at a single time point have been associated with SNAEs. However, whether changes in these biomarker levels predict SNAEs in HIV-1-infected persons is unknown. We hypothesized that greater decreases in inflammatory biomarkers would be associated with fewer SNAEs. We identified 39 patients with SNAEs, including major cardiovascular events, end stage renal disease, decompensated cirrhosis, non-AIDS-defining malignancies, and death of unknown cause, and age- and sex-matched HIV-1-infected controls. sCD14, sCD163, and IL-6 were measured at study enrollment (T1) and proximal to the event (T2) or equivalent duration in matched controls. Over ∼34 months, unchanged rather than decreasing levels of sCD14 and IL-6 predicted SNAEs. Older age and current illicit substance abuse, but not HCV coinfection, were associated with SNAEs. In a multivariate analysis, older age, illicit substance use, and unchanged IL-6 levels remained significantly associated with SNAEs. Thus, the trajectories of sCD14 and IL-6 levels predict SNAEs. Interventions to decrease illicit substance use may decrease the risk of SNAEs in HIV-1-infected persons.

10.1089/aid.2016.0007

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Citations (21)

Correction: Effects of Combined CCR5/Integrase Inhibitors-Based Regimen on Mucosal Immunity in HIV-Infected Patients Naïve to Antiretroviral Therapy: A Pilot Randomized Trial

PLoS Pathogens (2017)

Sergio Serrano‐Villar Talía Sainz Zhongmin Ma Netanya S. Utay Tae Wook-Chun

[This corrects the article DOI: 10.1371/journal.ppat.1005381.].

Regimen

Integrase inhibitor

10.1371/journal.ppat.1006368

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