We review our experience from January 1987 to September 1992 with the surgical treatment of complex congenital malformations requiring an extracardiac homograft-valved conduit. There were 10 patients in the series; 7 pulmonary and 3 aortic homografts were implanted. Ages ranged from 1 month to 26 years (mean 7.9). There were 4 cases of hospital mortality, none related to the homograft itself. The major postoperative complication was low cardiac output syndrome. The 6 survivors have been followed between 3 months and 5 years and no dysfunction of the valved homograft, thromboembolism, or hemolysis have been recorded. All the survivors are symptom-free with a good quality of life. The use of homografts is advised in selected cases of right and left ventricular tract reconstruction for congenital heart disease; homografts are easy to handle and offer several technical advantages over prosthetic tissues.
Objective The aim of this study is to discuss the role of psychiatric and psychological factors on the onset of irritable bowel syndrome(IBS) and the differences between males and females through comparing the levels of anxiety,depression between IBS patients and healthy subjects and between male and female IBS patients.Methods A total of 50 patients with IBS were diagnosed by using the Rome Ⅱ criteria.50 healthy subjects participated in the study.Anxiety and depression were assessed by Zung self-rating anxiety scale(SAS) and self-rating depression scale(SDS) respectively.Results The scores of anxiety and depression were significantly higher in IBS patients than those in healthy subjects(53.31i13.77 vs(41.14)±7.92;51.95±13.87 vs 42.29±8.15,P0.001),while there is no difference between male and female IBS patients(51.88±13.92 vs 54.73±12.61;51.34±14.07 vs 52.56±13.69,P0.05).Conclusion Anxiety and depression happened more often in IBS patients than that in healthy subjects and may induce the onset of IBS.While there was no difference in psychiatric and psychological factors between male and female IBS patients.
Objective To investigate the variant expression of NF\|κBp65 and c\|myc protein and their relationships in gastric carcinogenesis. Methods A total of 41 primary gastric tumors and 24 corresponding noncancer specimens were examined. Expression of activated NF\|κB and c\|myc protein were determinded by immunohistochemistry. Results (1) In normal mucosa\|intestinal metaplasia\|dysplasia\|neoplasia, p65 expression were 0, 34.78%, 53.33%, 60.98%,while c\|myc protein were 0, 30.43%, 53.33%, 58.54%, respectively.The two parameters were significantly increased in dysplasia and carcinoma, compared to normal mucosa, while the expression level were also significantly higher in carcinoma than in intestinal metaplasia ( P 0.05).(2) The expression of NF\|κBp65 and c\|myc protein were significantly increased in the poorly differentiated group,advanced gastric carcinoma ,lymph node metastasis and those which had invaded to serosa( P 0.05).(3) There were moderate or intense relationships between p65 and c\|myc protein ( r s =0.621～0.845, P 0.01). Conclusion The expression of NF\|κBp65 and c\|myc protein are up\|regulated at an early stage of the gastric carcinogenesis. NF\|κB may contribute to the overexpression of c\|myc protein who may play an important role as the downstream response factor in the gastric carcinogenesis.
Objective To compare the therapeutic effect of electroacupuncture (EA) and fluoxetine for treating depression Methods Ninety five outpatients with major depressive episode were randomly assigned into three different treatment groups: EA (31), fluoxetine (32) and control group (32) The EA group was given acupuncture at Baihui and Yintang points and placebo capsules; fluoxetine group given fluoxetine 20 mg daily and sham acupuncture; and control given placebo capsules and sham acupuncture All treatment lasted for 6 weeks All subjects were rated every 2 weeks with the Hamilton Rating Scale for Depression (HAMD), Asberg Rating Scale for Side Effects(SERS), Self rating Depression Scale (SDS), Clinical Global Impression (CGI) for evaluating the therapeutic effect Results At the end of the 6 week treatment, there were better improvement in EA group compared to controls on both the HAMD score (10 19± 5 88 vs 13 88±8 29; P 0 05) and SDS score (53 02±9 67 vs 60 00±12 89; P 0 05), and the severity of illness on CGI score was worse in controls (3 16±1 32) than in EA (2 42±1 03) and fluoxetine (2 56±1 13) groups ( P 0 05) There was no significant difference between the EA and fluoxetine groups on any of the rating scores Conclusion EA is at least as efficacious as fluoxetine for treating patients with major depressive disorder
Purpose:To investigate the variant expression of human belomerase reverse transcriptase (hTERT) and NF κB p65 protein and their relationships in gastric carcinogenesis.Methods:A total of 41 primary gastric cancers, 15 cases dysplasia, 23 cases intestinal metaplasia and 10 cases normal gastric mucosa were taken into this study. Expression of hTERTmRNT, hTERT protein and p65 protein were determined by in situ hybridization and immunohistochemistry. Results:①Among normal mucosa intestinal metaplasia dysplasia carcinoma,p65 expression were 0?34.18%(8/23)?53.33%(8/15)?60.98%(25/41),hTERTmRNA 10.00%(1/10)?39.13%(9.23)?66.67%(10/15)?85.37%(35/41) and hTERT protein 0?30.43%(7/23)?60.00%(9/15)?78 05%(32/41),respectively. All the three parameters were significantly increased in dysplasia and carcinoma, compared to normal mucosa, while the expression level were also significantly higher in carcinoma than in intestinal metaplasia ( P 0 05).②The expression of p65 and hTERT protein were significantly increased in the poorly differentiated carcinoma, lymph node metastasis, advanced carcinoma and those which had invaded into the serosa ( P 0 01～0 05). hTERT mRNA expression was significantly higher only in advanced carcinoma. ③There were moderate or intense relationships between p65 and hTERT mRNT (r s=0.661～0.752, P 0 01),hTERT protein and mRNA(r s=0.609～0.750, P 0 01),respectively. Conclusions:NF κBp65 and hTERT expression are up regulated at an early stage of gastric carcinogenesis. NF κB may contribute to the activation of hTERT expression and thereby enhance telomerase activity representing an important step in carcinogenesis progress.
Between January 1987 and October 1992, 11 neonates and 2 infants (12 males and 1 female) underwent arterial switch operation (ASO). There were 9 simple transpositions of great arteries (TGA), 3 TGA with ventricular septal defect (VSD), and 1 double outlet of right ventricle (Taussig-Bing) with TGA. There were 12 cases of patent ductus arteriosus (PDA) and 6 cases of atrial septal defect (ASD). Nine patients had Yacoub type A coronary pattern, 3 had type B, and 1 had type D. The neonates' mean age was 15.5 days (one 120 days old and one 22 months old). The average body weight of the neonates was 4.2 kg. The Lecompte maneuver was performed on all patients. The average bypass time was 187.8 min, and mean aortic cross-clamp time was 76.2 min, with a mean circulatory arrest time of 10 min in 6 cases. Early hospital mortality was 15.4% (2 deaths)—1 patient died during operation from myocardial infarction, and another died postoperatively from poor heart function. All survivors experienced early postoperative heart failure and needed temporary inotropic support. One patient was lost to follow-up. The other 10 patients were free from any cardiac symptoms at follow-up, with good left ventricular function. Mild to moderate aortic regurgitation and stenosis and the same in the pulmonary valve were seen on echocardiogram. Seventeen months after ASO, 1 patient required reoperation for severe postoperative pulmonary stenosis. We concluded that ASO can be performed with an acceptable mortality rate in a new unit with no previous experience of such surgery.
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