Subha Rai

National JALMA Institute for Leprosy & Other Mycobacterial Diseases

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Om Parkash

Indian Institute of Wheat and Barley Research

Archna Pandey

National JALMA Institute for Leprosy & Other Mycobacterial Diseases

B K Girdhar

National JALMA Institute for Leprosy & Other Mycobacterial Diseases

V.M. Katoch

National JALMA Institute for Leprosy & Other Mycobacterial Diseases

Vishwa Mohan Katoch

Rajasthan University of Health Sciences

Geeta Gupta

Santosh University

Mansi Sachdev

Fortis Memorial Research Institute

S. Kapoor

University of Pittsburgh Medical Center

Harpeet Singh

Tanu Singhal

Kokilaben Dhirubhai Ambani Hospital

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National JALMA Institute for Leprosy & Other Mycobacterial Diseases

Indian Council of Medical Research

London School of Hygiene & Tropical Medicine

All India Institute of Medical Sciences

Indira Gandhi Medical College

Indian Institute of Wheat and Barley Research

Chandka Medical College

Cleveland Clinic

Reading Hospital

Aga Khan University

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Detection of Mycobacterium leprae DNA for 36kDa protein in urine from leprosy patients: a preliminary report

Revista do Instituto de Medicina Tropical de São Paulo (2004)

Om Parkash Hari Bhan Singh Subha Rai Archna Pandey Vishwa Mohan Katoch

We have searched for Mycobacterium leprae DNA for 36kDa protein in urine using a M. leprae specific PCR technique. A limited number of 16 patients (of which 11 belonged to lepromatous leprosy and five to tuberculoid leprosy) and eight healthy individuals were included for the present study. The number of urine samples positive by PCR were 36.4% (4/11) in lepromatous patients and 40% (2/5) in tuberculoid patients. None of the samples from healthy individuals was positive. To our knowledge, the results indicate, for the first time, the presence of M. leprae DNA in urine from leprosy patients. Another important finding obtained out of the study is that amongst treated patients 66.6% (4/6) were positive whereas amongst untreated only 20% (2/10) were positive. From the present indicative data it appears that treatment improves the PCR results with urine as a sample. Thus, the approach could prove to be useful for monitoring the treatment response of individual patients and needs to be further evaluated with a large number of patients.

Mycobacterium leprae

Tuberculoid leprosy

10.1590/s0036-46652004000500008

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Detection of Mycobacterium leprae infection: some new approaches

Journal of Immunology and Immunopathology (2004)

Om Parkash Harpeet Singh Subha Rai Archna Pandey Mansi Sachdev

At this juncture, the existing laboratory diagnostic assays are not efficient enough to detect 100% cases of leprosy. With the view to find some better tool(s) we have carried out several investigations employing various specimens (including blood, urine and skin scrapes) from leprosy patients and healthy individuals. In these efforts we have got some encouraging indicative results. All these findings opens up several new areas which needs further exploration.

Mycobacterium leprae

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