R. L. L. Simmons

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Antibody responses to vaccination with WRL 105 strain live influenza vaccine in previously vaccinated and unvaccinated volunteers

Journal of Hygiene (1979)

A. E. J. Evans R. L. L. Simmons R.D. Ferris S.K. Hasell E. Letley

SUMMARY Intranasal vaccination with a single 0·5 ml dose of 10 7.0 EID 50 WRL 105 strain live influenza vaccine elicited four-fold or greater increases in circulating homotypic haemagglutinating inhibiting (HAT) antibody in 60 (64·5 %) of 93 volunteers, or in 58 (74·4%) of 78 volunteers with HAI antibody titres before vaccination of ≤ 1/20. In comparison, in a group of volunteers vaccinated 9 months previously re-vaccination elicited antibody responses in only 4 (6·9 %) of 58 volunteers, or in 3 (14·3%) of 21 volunteers with antibody titres before vaccination of ≤ 1/20. Titres of vaccine-induced antibody and antibody resulting from earlier natural infection appeared to fall slowly and at equivalent rates over a 9 month period.

Antibody response

10.1017/s0022172400054012

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Citations (3)

LONGER TERM EFFECTS OF LIVE INFLUENZA VACCINE IN PATIENTS WITH CHRONIC PULMONARY DISEASE

The Lancet (1977)

P.J. Fell NA Watson Hilary O‘Donnell R. L. L. Simmons S.K. Hasell

Wheeze

Chronic bronchitis

10.1016/s0140-6736(77)91319-8

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Citations (18)

Disseminated Varicella Infection Caused by Varicella Vaccine Strain in a Child With Low Invariant Natural Killer T Cells and Diminished CD1d Expression

The Journal of Infectious Diseases (2011)

Tatjana Banovic Mayonelo Yanilla R. L. L. Simmons IAN F. ROBERTSON Wayne A. Schroder

Background. Live attenuated varicella vaccine is considered a safe vaccine with serious adverse effects reported only in immunocompromised children. We describe a severe life-threatening infection with varicella vaccine virus causing rash and pneumonitis in a 6-year-old boy with no apparent immunodeficiency.

Varicella zoster virus

Chicken Pox

10.1093/infdis/jir660

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Citations (76)

Comparison of antibody responses and virus shedding following administration of trivalent oral poliomyelitis vaccines prepared either in monkey kidney or human diploid cell substrates

Journal of Hygiene (1980)

D. S. Freestone Anthony J Kelly R.D. Ferris R. L. L. Simmons C. Bowkerj

SUMMARY Nineteen (22·9%) of 83 sera collected before vaccination from adult volunteers aged 21–64 years were without neutralizing antibody to poliomyeitis at levels of 0·15 i.u./ml for types I and II and 0·1 i.u./ml for type III. Some correlations were found between the history of previous vaccination and the presence of antibody but these were not well defined. Vaccination with a single dose of trivalent oral polio vaccine elicited fourfold or greater antibody responses to one or more poliomyelitis types in 53 (63·9%) volunteers, the percentage antibody responses being inversely related to the titre of antibody present before vaccination. Types I, II or III poliomyelitis virus were recovered from 76·8 % of faecal samples collected 1 week after vaccination. The percentage recovery progressively declined thereafter until virus was recovered from 10·5 % of samples collected 6 weeks after vaccination. Type for type, the titres and percentages of antibody responses and virus shedding in faeces were similar following trivalent oral poliomyelitis vaccines whether prepared in monkey kidney or human diploid cell substrates. Some change in reproductive capacity temperature (r.c.t./40) marker was found in faecal isolates from volunteers vaccinated with monkey kidney and human diploid grown vaccines but no change in ‘d’ marker was found.

Antibody titer

10.1017/s0022172400026474

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Citations (4)