Abstract The title compounds (III) are obtained via a two‐step one‐pot synthesis involving the construction of the cyclohexanone ring from aromatic aldehydes and β‐ketoesters as initial step under mild reaction conditions.
Designed as potential cytotoxic agents a series of 6-substituted 2,3-dihydro-1H-pyrrolo[3,2,1-ij]quinoline derivatives were synthesized by using a Bischler type reaction. The methodology involved the cyclodehydration of 2-(3,4-dihydroquinolin-1(2H)-yl)-1-alkyl/aryl ethanones in the presence of p-TSA under ultrasound irradiation. A number of compounds were prepared using this methodology and tested for their in vitro anti-proliferative properties against cancer (leukemia) and non-cancerous cell lines. Some of the compounds showed promising and selective cytotoxic effects toward leukemia cells.
Ferromagnetic FeCo nanoparticles were prepared by a simple one-pot polyol process and followed by simple annealing treatment. The prepared ferromagnetic FeCo nanoparticles have spherical shape and the size was controlled by the annealing temperature. Importantly, single FeCo phase was obtained at 400°C and these samples have spherical shape and size about 50 nm. While at higher temperature (at 600°C) the nanoparticles have very lower aggregation and have higher coercivity. The prepared FeCo nanoparticle at low temperature with good magnetic properties are to be considered as potential candidate for many applications.
Abstract The 4,5,6,7-tetrahydro-1H-indazol-3(2H)-one derivatives have been synthesized in good yields via a two-step method in a single pot. The initial step involved the construction of cyclohexanone ring from aromatic aldehydes and β-ketoester in i-PrOH using an inexpensive and reusable catalyst (i.e., Amberlyst A-21) under mild reaction conditions. The utility of this catalyst has been demonstrated in synthesizing a range of cyclohexanone derivatives. The catalyst can be recovered and recycled, which makes this procedure simple, convenient, economically viable, and environmental friendly. [Supplementary materials are available for this article. Go to the publisher's online edition of Synthetic Communications® for the following free supplemental resource(s): Full experimental and spectral details.]
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