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Martina Deckert

University of Cologne

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Anna Brunn

University Hospital Cologne

Manuel Montesinos‐Rongen

University of Cologne

Reiner Siebert

Universität Ulm

Cornelius Courts

University Hospital Cologne

Heinrich Schwindt

Heinrich Heine University Düsseldorf

Wolff Schmiegel

Universitätsklinikum Knappschaftskrankenhaus Bochum

Werner Kempf

University Hospital of Zurich

Benedikt Schoser

Friedrich Baur Stiftung

Charles Antzelevitch

Thomas Jefferson University

Renzo Guerrini

University of Florence

Cooperative Institutions

University of Cologne

Heidelberg University

University Hospital Cologne

German Cancer Research Center

University Hospital Heidelberg

Matrix Research (United States)

Heinrich Heine University Düsseldorf

Harvard University

Düsseldorf University Hospital

Deutschen Konsortium für Translationale Krebsforschung

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European Association of Neuro-Oncology (EANO) guidelines for treatment of primary central nervous system lymphoma (PCNSL)

Neuro-Oncology (2022)

Khê Hoang‐Xuan Martina Deckert Andrés J.M. Ferreri Julia Furtner Jaime Gállego Pérez‐Larraya

The management of primary central nervous system (PCNSL) is one of the most controversial topics in neuro-oncology because of the complexity of the disease and the limited number of controlled studies available. In 2021, given recent advances and the publication of practice-changing randomized trials, the European Association of Neuro-Oncology (EANO) created a multidisciplinary task force to update the previously published evidence-based guidelines for immunocompetent adult patients with PCNSL and added a section on immunosuppressed patients. The guideline provides consensus considerations and recommendations for the treatment of PCNSL, including intraocular manifestations and specific management of the elderly. The main changes from the previous guideline include strengthened evidence for the consolidation with ASCT in first-line treatment, prospectively assessed chemotherapy combinations for both young and elderly patients, clarification of the role of rituximab even though the data remain inconclusive, of the role of new agents, and the incorporation of immunosuppressed patients and primary ocular lymphoma. The guideline should aid the clinicians in everyday practice and decision making and serve as a basis for future research in the field.

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10.1093/neuonc/noac196

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Citations (76)

Immunohistochemical determination of protein kinase C expression and proliferative activity in human brain tumors

Acta Neuropathologica (1989)

Guido Reifenberger Martina Deckert W. Wechsler

10.1007/bf00688205

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Differenzialdiagnose lymphoider Infiltrate im Zentralnervensystem

Der Pathologe (2013)

Wolfgang Brück Anna Brunn Wolfram Klapper Thomas Kuhlmann Imke Metz

10.1007/s00292-013-1742-9

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Anaplastic astrocytoma with piloid features, a novel molecular class of IDH wildtype glioma with recurrent MAPK pathway, CDKN2A/B and ATRX alterations

Acta Neuropathologica (2018)

Annekathrin Reinhardt Damian Stichel Daniel Schrimpf Felix Sahm Andrey Korshunov

ATRX

Pilocytic astrocytoma

Anaplastic astrocytoma

Anaplastic large-cell lymphoma

10.1007/s00401-018-1837-8

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Citations (236)

Springer eBooks (2009)

Alexander K. C. Leung William Lane M. Robson Carsten Büning Johann Ockenga Janine Büttner

10.1007/978-3-540-29676-8_6089

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Springer eBooks (2009)

Alexander K. C. Leung William Lane M. Robson Carsten Büning Johann Ockenga Janine Büttner

10.1007/978-3-540-29676-8_6137

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Springer eBooks (2009)

Alexander K. C. Leung William Lane M. Robson Carsten Büning Johann Ockenga Janine Büttner

10.1007/978-3-540-29676-8_8335

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Springer eBooks (2009)

Alexander K. C. Leung William Lane M. Robson Carsten Büning Johann Ockenga Janine Büttner

10.1007/978-3-540-29676-8_6042

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IL-10, IL-4, and STAT6 Promote an M2 Milieu Required for Termination of P0106-125-Induced Murine Experimental Autoimmune Neuritis

American Journal Of Pathology (2014)

Anna Brunn Mirna Mihelčić Mariana Carstov Lea Hummel Frank Geier

Neuritis

Macrophage polarization

10.1016/j.ajpath.2014.06.012

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Lymphocytopenia

Springer eBooks (2009)

Alexander K. C. Leung William Lane M. Robson Carsten Büning Johann Ockenga Janine Büttner

10.1007/978-3-540-29676-8_6283

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