Summary HLA ‐G is a nonclassical Class I major histocompatibility complex ( MHC ) gene. This gene has a limited protein alteration that is produced by alternative splicing and can be important in the preservation of pregnancy. Recent findings suggest that alteration in HLA ‐G gene expression can lead to pregnancy failure, such as recurrent pregnancy loss ( RPL ). As the promoter SNP s of the gene may impact the HLA ‐G expression levels, the study of these SNP s is very important. In this study, for the promoter region of HLA ‐G gene in the case group (100 women with a history of two or more repeated miscarriages) and the control group (100 women with at least two successful pregnancies), PCR reaction was performed. Thereafter, PCR products were sequenced and the results were compared between the two groups. The results showed that −1573T>C and −1746C>A SNP s in the promoter of the HLA ‐G gene associated with RPL . The outcome of the haplotype analysis also showed that the association of two haplotypes, including H1 ( ATCCAGGTACGCAA ) and H2 ( CTTCGAGAACGCAG ) with RPL , is significant. The results showed that H1 is associated with a decreased and H2 is associated with an increased risk of RPL . These results indicate the importance of the HLA ‐G promoter SNP s in the pregnancy outcome. But to reach a more definite conclusion, subsequent studies on 3′ UTR and other positions with polymorphism in the 5′ UTR regions larger samples are necessary.
Introduction: Non-ossifying Fibroma (NOF) is a relatively common benign and non-neoplastic lesion in long bones of children and adolescents. As far as very few cases of NOF have been reported in jaws and what was managed to be found regarding all reported cases having occurred only in the mandible, in this article we are going to report a case of maxillary NOF in a 38-year-old female.
<p>Mothers and their fetuses are hereditarily unlike. Surprisingly, no less than 50% human pregnancies reach full term despite the tendency of the immune system to eliminate of non-self units. Reduction of adaptive maternal immune answer, which is planned to reject strange factors, is essential for a pregnancy to reach full term. However, approximately 5% couples trying to conceive experience 2 recurrent miscarriages (RMs).</p><p>HLA-G, which is produced by the external trophectoderm layer and has unique biological features, is involved in the implantation and maintenance of fetus. Serum HLA-G levels are correlated with the risk of RM. Recent studies indicate that a 14-bp HLA-G, INDEL polymorphism decreases the level of <em>HLA-G</em> mRNA, which in turn decreases the amount of HLA-G produced. An understanding of gene parameter and the function of polymorphic sites in the functioning of <em>HLA-G</em> products may enable the development of approaches targeting <em>HLA-G</em> for more detail of causes of RM.</p>
Background: The benefits of addressing behavioral health issues in inpatients have been well documented. However, these problems are not frequently recognized by physicians during the hospitalization of patients in general hospitals. Objectives: This study described the current status and medical diagnoses made in psychiatric consultations to inpatients admitted to general hospitals affiliated to Babol University of Medical Sciences, North of Iran. Methods: This cross-sectional observational research was carried out at Babol University of Medical Sciences from 2019 to 2020. All psychiatric consultations for patients hospitalized in different departments of two general hospitals affiliated to this university for 6 months were included. The mental disorders diagnosed for patients were recorded by a psychiatrist according to the diagnostic and statistical manual of mental disorders (DSM-5) criteria. Results: A total of 266 patients with a mean age of 51.21 ± 16.95 years were examined. Most of the consults were requested by the departments of cardiology (39.5%) and neurology (16.2%). According to the psychiatric visits, 32.3%, 51.1%, and 15.4% of the patients had no, one, and two concomitant psychiatric disorders, respectively. Mental disorders were found to have a significant association with gender (P < 0.001), admission department (P < 0.001), comorbid malignancies (P = 0.011), cardiovascular disorders (P < 0.001), need for surgical intervention (P = 0.018), a history of substance use (P = 0.001), and reasons for consult request (P < 0.001). Conclusions: Mental disorders, especially mood and anxiety disorders, were identified in approximately 70% of consultations. Therefore, requesting a timely psychiatric consultation can lead to better managing hospitalized patients.
This article is an attempt to provide an overview of systematic reviews to determine the efficacy of CQ10 supplementation in the treatment of patients with cardiovascular diseases (CVD). All reviews were identified through a systematic search of the following databases: Cochrane, DARE, Ovid, EMBASE, ISI Web of Knowledge, and PubMed. Check references studies and the quality of the studies was assessed by means of AMSTTAR. No meta-analyses were performed due to the heterogeneity of studies. Extracted data for Seven systematic reviews for primary outcomes, net changes in cardiac output, cardiac index, New York Heart Association functional classification, improved survival, based on existing evidence, there is a case for use of CoQ10 as an adjunctive therapy in congestive heart failure, especially in those patients unable to tolerate mainstream medical therapies. Evidence suggests that the CoQ10 supplement may be a useful tool for managing patients with heart failure.
ABSTRACT Aim This is to report a rare case of ameloblastic fibrodentinoma (AFD), including detailed history, histopathologic as well as radiographic findings. Her condition, a mixed odontogenic tumor, has rarely been reported in publications. We also included the gist of theories put forward regarding the histogenesis of this lesion. Background AFD is a rare and controversial entity; it boasts a variety of classifications and terminology based on its unique biological nature as well as histopathological features. Case description The patient was a 13-year-old girl with a chief complaint of central unerupted tooth on the left mandible. Cone beam computed tomographic images revealed a mixed pericoronal and multilocular lesion surrounding the crown of the aforementioned tooth, displacing it apically to a large extent. Conclusion It is important to differentiate AFD from other benign mixed odontogenic tumors with similar radiographic appearance because of different therapeutic approaches in some of these tumors. Clinical significance From the clinical point of view, it is of paramount significance for dental practitioners to assess any delayed tooth eruption (more than 6 months and in comparison with its counterpart on the opposite side) radiographically to ascertain or rule out any such similar lesions. How to cite this article Salehinejad J, Langaroodi AJ, Shahakbari R, Yazdani N. Ameloblastic Fibrodentinoma: Report of a Rare Case. J Contemp Dent Pract 2013;14(3):548-551.
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