Xiaoling Guo

Second Hospital of Hebei Medical University

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Chao Li

China Southern Power Grid (China)

Yun‐Yin Niu

Zhengzhou University

Jiansu Chen

First Affiliated Hospital of Jinan University

Shulan Yang

The First Affiliated Hospital, Sun Yat-sen University

Haihe Wang

Sun Yat-sen University

Xian Shen

Wenzhou Medical University

Ruiling Lian

Jinan University

Rongjie Yu

Jinan University

Maoping Chu

Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University

Zuo-Ren Dong

Hebei Medical University

Cooperative Institutions

Wenzhou Medical University

Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University

Sun Yat-sen University

Chinese Academy of Medical Sciences & Peking Union Medical College

Chinese Academy of Sciences

Zhengzhou University

Hebei Medical University

Peking University

Jinan University

Shanghai Jiao Tong University

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

Expression patterns of pcbp gene family members during zebrafish embryogenesis

Gene Expression Patterns (2020)

Jie Wang Xiaoling Guo Dongxian Wang Shulan Yang

Danio

Protein family

10.1016/j.gep.2020.119097

Cite

Citations (3)

Activation and up‐regulation of translation initiation factor 4B contribute to arsenic‐induced transformation

Molecular Carcinogenesis (2011)

Yong Zhang Qing Wang Xiaoling Guo Robert D. Miller Yinglu Guo

Abstract Arsenic is a known human carcinogen. However, the mechanism of how arsenic induces cell transformation remains unclear. In this study, we demonstrated that long‐term exposure to sodium arsenite at low‐dose (2 µM) increases cell proliferation and neoplastic transformation in a mouse epidermal cell model, JB6 promotion‐susceptible cells. The phosphorylation of AKT and its downstream targets, 70‐kDa ribosomal protein S6 kinase (p70S6K) and translation initiation factor 4B (eIF4B), are increased in the arsenite treated cells, indicating that long‐term arsenite treatment activates AKT–p70S6K signaling pathway. In addition, long‐term exposure to arsenite up‐regulates eIF4B expression and increases the rate of translation. Knockdown of eIF4B expression resulted in inhibition of arsenic‐induced cell proliferation, transformation, and translation. Moreover, the expression of c‐Myc which is up‐regulated by long‐term arsenite treatment is inhibited by eIF4B knockdown. Taken together, these results indicate that activation and up‐regulation of eIF4B contributes to arsenic‐induced transformation in JB6 cells. Mol. Carcinog. © 2011 Wiley‐Liss, Inc.

Sodium arsenite

Ribosomal protein s6

10.1002/mc.20733

Cite

Citations (16)

Generation of an induced pluripotent stem cell line from a Bartter syndrome patient with the homozygote mutation p.A244D (c.731C>A) in SLC12A1 gene

Stem Cell Research (2021)

Weiping Ji Dexuan Wang Congde Chen Huihui Chen Yinjuan Ding

Bartter Syndrome (BS) is a group of rare inherited autosome-recessive disease, which can be caused by the gene mutations of sodium-potassium-chloride cotransporter gene (SLC12A1). Here, the urine cells (UCs) derived from a 4-year-old female BS patient with the homozygote SLC12A1 gene mutation p.A244D (c.731C>A) were reprogramming into induced pluripotent stem cells (iPSCs) named WMUi019-A using a commercial Sendai virus reprogramming kit. The pluripotent stem cell markers like OCT4 and SSEA4 can be positively expressed in this iPSC line, which can also be induced to differentiate into three germ layers in vitro and maintain a stable karyotype (46, XY).

Bartter syndrome

Line (geometry)

10.1016/j.scr.2021.102228

Cite

Citations (1)

A First-in-Human Phase 1/2 Study of the Menin-KMT2A(MLL1) Inhibitor BN104 in Adult Patients with Relapsed or Refractory Acute Leukemia

Blood (2024)

Depei Wu Ying Wang Suning Chen Yuhua Li Rui Huang

Refractory (planetary science)

10.1182/blood-2024-198959

Cite

Citations (0)

10× improvement of power transmission over free space using integrated antennas on silicon substrates

Jau-Jr Lin Xiaoling Guo Ran Li John Branch J.E. Brewer

This paper reports the techniques for improving the characteristics of integrated antennas fabricated on silicon substrates for communications over air. Using these, the pair gain (G/sub a/) of antennas on 20-/spl Omega/-cm substrates has been improved by /spl sim/10/spl times/ over the previously reported result. Lastly, the possibility of realizing single chip radios with integrated antennas for communication over air is suggested by picking up, amplifying, and frequency dividing a 15-GHz sine wave transmitted from a 2-mm long on-chip antenna located 40 cm away using a packaged clock receiver with a 2-mm long on-chip zigzag antenna.

Zigzag

10.1109/cicc.2004.1358923

Cite

Citations (21)

Transduced protein transduction domain linked HSP27 protected LECs against UVB radiation-induced damage

Experimental Eye Research (2014)

Lian Liu Rongjie Yu Yuehuan Shi Yun Dai Zhixing Zeng

Hsp27

10.1016/j.exer.2013.12.016

Cite

Citations (23)

Effectiveness and safety of orelabrutinib with rituximab and lenalidomide in low KPS score and elderly patients with newly diagnosed primary central nervous system lymphoma—a single-center retrospective study

Neurological Sciences (2024)

Xiaoling Guo Ziyu Zhao Xuefei Guo Ya–Bei Zuo Jin-Ao Li

Single Center

Neuroradiology

10.1007/s10072-024-07348-4

Cite

Citations (0)

[Construct Mxi1 mutation gene expression vector from leukemia cell line KG1].

PubMed (2012)

Xiaoling Guo Zhi-Yun Niu Gailing Zhang Feng-Lei Yin Ling Yang

To construct the eukaryotic expression vector for Max interacting protein 1 (Mxi1).The full length cDNA of Mxi1 gene obtained from fetal lymphocyte and KG1 cells were inserted into plasmid pDs-red2-N1 respectively to generate pDs-red2-N1/Mri1 (wild/mutation type). Then the recombinant vector was transfected into Cos-7 cells via liposome. 48 hours post transfection, mRNA of Mri1 gene was detected by RT-PCR and Mxi1 protein expression was detected by flow cytometry and fluorescence microscope in the Cos-7 cells.The eukaryotic expression vector of Mxi1 was constructed and transfected into eukaryotic cells successfully. The expression of red fluorescence protein in the transfected Cos-7 cells was observed under fluorescence microscope which implied the expression of Mxi1. The transfect efficiency of both wild and mutation type were in a high level in 3 days after transfected, which lasted to 6 d. RT-PCR amplified the total RNA extracted from the transfected Cos-7 cells could find increased mRNA level of Mxi1 gene.We successfully constructed the eukaryote expression vector for Mri1 gene; Cos-7 cells transfected with the vector via liposome could express Mxi1 protein. These could be useful for the further study of the Myc gene modulation.

Source

Cite

Citations (0)

Independent oncogenic and therapeutic significance of phosphatase PRL‐3 in FLT3‐ITD–negative acute myeloid leukemia

Cancer (2014)

Shuang Qu Bin Liu Xiaoling Guo Hongshun Shi Meifeng Zhou

BACKGROUND Internal tandem duplication of FMS‐like tyrosine kinase (FLT3‐ITD) is well known to be involved in acute myeloid leukemia (AML) progression, but FLT3‐ITD–negative AML cases account for 70% to 80% of AML, and the mechanisms underlying their pathology remain unclear. This study identifies protein tyrosine phophatase PRL‐3 as a key mediator of FLT3‐ITD–negative AML. METHODS A total of 112 FLT3‐ITD–negative AML patients were sampled between 2010 and 2013, and the occurrence of PRL‐3 hyperexpression in FLT3‐ITD–negative AML was evaluated by multivariate probit regression analysis. Overexpression or depletion of endogenous PRL‐3 expression with the specific small interfering RNAs was performed to investigate the role of PRL‐3 in AML progression. Xenograft models were also used to confirm the oncogenic role of PRL‐3. RESULTS Compared to healthy donors, PRL‐3 is upregulated more than 3‐fold in 40.2% of FLT3‐ITD–negative AML patients. PRL‐3 expression level is adversely correlated to the overall survival of the AML patients, and the AML relapses accompany with re‐upregulation of PRL‐3. Mechanistically, aberrant PRL‐3 expression promoted cell cycle progression and enhanced the antiapoptotic machinery of AML cells to drug cytotoxicity through downregulation of p21 and upregulation of Cyclin D1 and CDK2 and activation of STAT5 and AKT. Depletion of endogenous PRL‐3 sensitizes AML cells to therapeutic drugs, concomitant with apoptosis by upregulation of cleaved PARP (poly ADP ribose polymerase) and apoptosis‐related caspases. Xenograft assays further confirmed PRL‐3's oncogenic role in leukemogenesis. CONCLUSIONS Our results demonstrated that PRL‐3 is a novel independent crucial player in both FLT3‐ITD–positive and FLT3‐ITD–negative AML and could be a potential therapeutic target. Cancer 2014;120:2130–2141. © 2014 The Authors. Cancer published by Wiley Periodicals, Inc. on behalf of American Cancer Society .

10.1002/cncr.28668

Cite

Citations (41)

Urine Screening and 9 Years’ Medical Record System Follow-Up Among School Students in Wenzhou, China

Frontiers in Pediatrics (2022)

Tingting Chen Qing Yang Hong Xu Yinv Gong Xiaoling Guo

School urinary screening programming can be useful for the early detection of renal and urinary disorders. However, urine screening is not included in the school health check-up in our region. Therefore, from February 2012 to March 2021, 12,497 school students were screened for urinalysis, and a long-term follow-up took place via an electronic medical record system. Among these screened students, 719 (5.75%) positive individuals received a repeat urinalysis 2 weeks later. During the 9-year medical record system follow-up period, 5 children had renal biopsies and 2 children had a diagnosis of IgA nephropathy (IgAN), while the remaining 3 children were diagnosed with thin basement membrane disease (TBM), primary nephrotic syndrome (PNS), and were suspected of C3 glomerulopathy, respectively. By this, calling for the school urine screening program as a physical examination item for primary and secondary school-aged students will contribute to enabling early detection of urine abnormalities and allow for early treatment.

Glomerulopathy

Medical record

10.3389/fped.2022.862029

Cite

Citations (2)