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Luisa Costa Penna Penido

Universidade Federal de Minas Gerais

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Flávia Xavier Valente

Universidade Federal de Viçosa

Maria do Carmo Gouveia Pelúzio

Universidade Federal de Viçosa

Damiana Diniz Rosa

Universidade Federal de Mato Grosso

María Isabel Toulson Davisson Correia

Universidade Federal de Minas Gerais

Jacques R. Nicoli

Universidade Federal de Minas Gerais

Lucilene Rezende Anastácio

Universidade Federal de Minas Gerais

Juliana Costa Liboredo

Universidade Federal de Minas Gerais

Maria Carolina Santos Mendes

Universidade Estadual de Campinas (UNICAMP)

Maria Beatriz Abreu Glória

Universidade Federal de Minas Gerais

Fernanda Guimarães Drummond e Silva

Universidade Federal de Ouro Preto

Cooperative Institutions

Universidade Federal de Minas Gerais

Universidade Federal de Viçosa

Universidade Federal de Ouro Preto

Centro Universitário de Sete Lagoas

Universidade Estadual de Campinas (UNICAMP)

Universidade Federal de Mato Grosso

Federico II University Hospital

Mater Dei Hospital

Regional Government of Madeira

Agencia Regional da Energia e Ambiente da Regiao Autonoma da Madeira

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Effect of probiotics on the development of dimethylhydrazine-induced preneoplastic lesions in the mice colon

Acta Cirúrgica Brasileira (2013)

Juliana Costa Liboredo Lucilene Rezende Anastácio Maria do Carmo Gouveia Pelúzio Flávia Xavier Valente Luisa Costa Penna Penido

PURPOSE: To determine the effect of probiotics on the development of chemically induced (1, 2-dimethylhydrazine) colonic preneoplastic lesions, in mice. METHODS: The animals were divided into five groups. The control group was injected with carcinogen alone and the other groups also received probiotics (1- Lactobacillus delbrueckii UFV-H2b20; 2- Bifidobacterium animalis var. lactis Bb12; 3- L. delbrueckii UFV-H2b20 plus B. animalis var. lactis Bb12; and 4- Saccharomyces boulardii) administered orally in drinking water throughout fourteen weeks. RESULTS: Consumption of lactobacilli and bifidobacteria alone resulted in a significant reduction of the total number of aberrant crypt foci (55.7% and 45.1%, respectively). Significant reduction in the number of these small foci (<3 aberrant crypts) was only observed in the group treated with lactobacilli (52.2%) in comparison to control group. The number of larger foci (>3 aberrant crypts) crypts had no significant reduction. CONCLUSION: L. delbrueckii UFV-H2b20 and B. animalis var. lactis Bb12 administered alone protect colonic preneoplastic lesions in mice, while the combined treatment of these bacteria and the administration of S.boulardii were not effective in reducing such colonic lesions.

1,2-Dimethylhydrazine

10.1590/s0102-86502013000500008

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Sodium butyrate does not decrease the evolution of precancerous lesions in rats

Acta Cirúrgica Brasileira (2010)

Fernanda Guimarães Drummond e Silva Luisa Costa Penna Penido Flávia Xavier Valente Maria Carolina Santos Mendes Damiana Diniz Rosa

To evaluate the preventive effect of sodium butyrate in the appearance of aberrant crypt foci (ACF) in rats after induction with the carcinogen 1,2-dimethylhydrazine (DMH).Forty Wistar rats were separated into four groups (n=10) distributed as follows: control 1, control 2, butyrate 1 and butyrate 2. The groups control 1 and butyrate 1 remained under experimentation for 4 weeks, while the groups control 2 and butyrate 2 remained for 8 weeks. In the first four weeks, the animals of the control groups received water ad libitum and the animals of the butyrate groups received a sodium butyrate solution (3.4%) ad libitum. Injections of the drug 1,2-dimethylhydrazine were applied during the two first weeks of the experiment in all the animals, concurrently with the application of sodium butyrate. The large intestine of the animals was removed, for the analysis of the ACF and of the content of polyamines. The animal feces were collected for the analysis of the SCFA profile.The spermidine presented a higher concentration in the group butyrate 2 in comparison to the group control 2. There was a significant difference in the concentration value (µmol/mL) of acetate in comparison to the groups control 2 and butyrate 2.The use of sodium butyrate together with the induction of colorectal cancer was not effective in the prevention of the disease progression.

Sodium butyrate

Aberrant crypt foci

1,2-Dimethylhydrazine

10.1590/s0102-86502010000600009

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Citations (5)