Xianmin Hu

Wuhan University of Science and Technology

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Jun Wang

Wuhan University of Science and Technology

Shulan Li

Ministry of Ecology and Environment

Jie Guo

Wannan Medical College

Juan Liu

Ministry of Agriculture and Rural Affairs

Jun Wang

Zhejiang Lab

Bingshu He

Hubei Provincial Women and Children's Hospital

Mengfan Liao

Wuhan University of Science and Technology

Xiaolu Cao

Wuhan University of Science and Technology

L. Zhang

Mengya Zhang

Guangzhou University

Cooperative Institutions

Wuhan University of Science and Technology

Huazhong University of Science and Technology

Chinese Academy of Sciences

Capital Medical University

Sichuan University

Ministry of Agriculture and Rural Affairs

Sun Yat-sen University

Wuhan University

China Pharmaceutical University

Shanghai Jiao Tong University

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Attitudes and opinions about ecopharmacovigilance from multi-disciplinary perspectives: a cross-sectional survey among academic researchers in China

Environmental Science and Pollution Research (2022)

Jun Wang Jian Gao Mengfan Liao Juan Liu Xianmin Hu

Discipline

Cross-sectional study

10.1007/s11356-022-22406-0

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Citations (1)

The protective role of Chitooligosaccharides against chronic ulcerative colitis induced by dextran sulfate sodium in mice

Journal of Functional Foods (2021)

Jie Guo Mengfan Liao Yujie Zhu Xianmin Hu Jun Wang

Chitooligosaccharides(COS) as potential functional food has been paid great attention because of their outstanding biological activities. Here, we found COS (250 and 500 mg/kg) protected against development of dextran sodium sulfate(DSS)- induced chronic experimental ulcerative colitis(UC) in mice. DSS-elevated serum and colonic tumor necrosis factor(TNF)-α, interleukin(IL)-1β and IL-6 levels were significantly supressed. TUNEL+ apoptoic cells and Cleaved Caspase-9 expression were downregulated, Ki-67+ proliferative cells in colonic crypts and Bcl-2/Bax ratio were upregulated in COS-treated colons compared to DSS controls. COS enhanced gut microbiota diversity and restored community structure in chronic UC mice. Colonic expression of TLR4, NF-κB, STAT3 and pSTAT3 was significantly decreased, but that of regenerating islet derived 3 gamma(Reg3g) was increased by COS. Overall, COS represents a treatment alternative in chronic UC management via ameliorating inflammation, promoting mucosal repair and modulating gut microbiota. Inhibition of TLR4 signal and induction of colonic Reg3g might be involved in molecular mechanisms.

10.1016/j.jff.2021.104809

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Pharmacy from the perspectives of other health professions: An intervention to foster professional identity among freshmen pharmacy students

Saudi Pharmaceutical Journal (2023)

Wenjing Chen Xianmin Hu Juan Liu Jun Wang

Professional identity is crucial for the development of pharmacy students' professional confidence, learning motivation and future career choices. However, how to develop students' professional identity in pharmacy education is an underdeveloped field of research. The critical component of professional identity has been considered formed as a result of stepwise socialization. Therefore, pharmacy professional identity might be influenced by associations with other health care professionals, such as physicians and nurses, who are involved in health care collaboration with pharmacists.This work aimed to investigate the effect of a student-led interview intervention called "Pharmacy from the perspectives of other health professions" as an intervention on pharmacy freshmen's perceptions and positivity toward the pharmacy profession.In this prospective pre/postintervention study, the effect of the interview intervention on students' job preferences as well as attitudes toward the pharmacy profession and pharmacists' role in health care was evaluated among 70 first-year pharmacy undergraduates equally divided into intervention and control groups using a self-developed questionnaire.Compared with the controls, the numbers of respondents reporting no specific reasons for selecting the pharmacy profession and stating that they were unclear about their preferred post-graduation work sector were significantly reduced after the intervention. Participating in the intervention increased the number of students who agreed or strongly agreed that they would have a fulfilling and socially respectable career. Significantly more students in the intervention group agreed with the pharmacists' role in health care as well as the current situation of pharmacy human resources than in the control group.This student-led interview intervention could be applied as an effective tool for improving students' professional identity and positivity in pharmacy education.

Graduation (instrument)

10.1016/j.jsps.2023.04.008

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Citations (1)

Effect of prenatal tetrandrine therapy on pulmonary vascular structural remodeling in the nitrofen-induced CDH rat model.

PubMed (2000)

Liu W Junpeng Feng Hongjun Jia Ying Tang Hu T

To examine the effects of prenatal tetrandrine (Tet) therapy on pulmonary arterial structural remodeling in nitrofen-induced congenital diaphragmatic hernia (CDH).CDH was induced in fetal rats by maternal administration of 100 mg nitrofen by gavage on day 9.5 of gestation (term, day 22). Control animals received olive oil (OO). Tet (24 mg/kg per day) or normal saline (NS) was given by gavage every day from 16 to 20 days of gestation, and fetuses were delivered by caesarean section on day 21.5. Lung sections from 3 fetuses in each group were studied. The number of vessels were calculated, the external diameter (ED), medial wall thickness (MT), percent of medial wall thickness, and wall structure were evaluated by image analysis software.In the pre-acinar arteries, CDH-NS pups had a significantly increased %MT compared with the OO-NS group (P < 0.05), while CDH-Tet animals had a reduced %MT compared with the CDH-NS rats (P < 0.05). Similar results were seen in the intra-acinar level. Significant differences were observed between CDH-NS animals and OO-NS controls in the percentage of muscularized intra-acinar blood vessels (P < 0.001). Tet-treated CDH pups had a reduced percentage of muscularized intra-acinar arteries compared with CDH-NS animals.Medial hypertrophy is present in both the pre-acinar and intra-acinar arteries in the nitrofen-induced CDH rat model. Tet treatment inhibits medial hypertrophy and reduces the percentage of muscularized intra-acinar vessels. Prenatal Tet therapy may be efficacious in reducing the risk of PH in human newborns with CDH.

Nitrofen

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Using a targeted ecopharmacovigilance intervention to control antibiotic pollution in a rural aquatic environment

The Science of The Total Environment (2019)

Jun Wang Mengya Zhang Juan Liu Xianmin Hu Bingshu He

10.1016/j.scitotenv.2019.134007

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Citations (22)

Mental Stress of Hospitalized Children

Zhongguo jiankang jiaoyu (2003)

Xianmin Hu

Mental stress

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Citations (0)

Knowledge, perceptions, and practice of ecopharmacovigilance among pharmacy professionals in China

Environmental Monitoring and Assessment (2017)

Juan Liu Jun Wang Xianmin Hu

10.1007/s10661-017-6289-4

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Citations (18)

Micro-management study of human resources maternity and child care centers in Shanxi province

Chinese Journal of Women and Children Health (2011)

Xianmin Hu

Objective To understand micro-management aspects of human resources by investigation in maternity and child care centers(MCH) institutions of Shanxi province.Methods 12 MCH across the province of Fully 663 staff interviews and questionnaires.Results Lack of a strict access system in terms of staff recruitment;there are many problems in staff training:lack of training needs assessment,a big gap between training and staff demand,not strong in practicality,a single form of training.Lack of scientific assessment indicators,the form of a single assessment,examination out of touch with the incentive mechanism,formality examination and so on.Conclusions Shanxi province MCH agencies to strengthen human resources management focus on personnel training,use,evaluation,incentives,security,and other links,establish talent development and characteristics of MCH personnel management system,promote human resources development and utilization of positive.

Formality

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Aldose reductase complexed with a nitro compound

Xuehua Zheng L. Zhang Y. Chen Hao Luo Xianmin Hu

10.2210/pdb3v35/pdb

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In Vivo anti-tumor effect of Eckol, a phlorotannin component isolated from brown algae, associated with regulating dendritic cells in sarcoma 180 (S180) xenografts-bearing mice

Proceedings for Annual Meeting of The Japanese Pharmacological Society (2018)

Jun Wang Mengya Zhang Shuqi Zhao Juan Liu Xianmin Hu

Background: Eckol is a marine natural product with potent biological activities, such as the antioxidant, cytoprotective properties, neuroprotective effect and anti-adipogenic activity. Previous study showed treatment of Eckol on U373 glioma cells cultured in sphere forming condition, which was induced by epidermal growth factor and basic fibroblast growth factor, dramatically suppressed the cell proliferation and the formation of spheres. In this study, we investigated the in vivo antitumor effect and possible mechanisms of Eckol on xenografted sarcoma 180 (S180) in mice.

10.1254/jpssuppl.wcp2018.0_po1-8-21

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Citations (2)