Qi‐Pin Qin

Yulin Normal University

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Ming‐Xiong Tan

Yulin Normal University

152

Bi‐Qun Zou

Guangxi Normal University

108

Yan‐Cheng Liu

Guangxi Normal University

Fu‐Pei Liang

Guangxi Normal University

Ting Meng

Southern University of Science and Technology

Hua‐Hong Zou

Guangxi Normal University

Hong Liang

Shanghai Ocean University

Zhenfeng Wang

Henan Agricultural University

Zhen‐Feng Chen

Guangxi Normal University

Hong Liang

Guangxi Normal University

Cooperative Institutions

Guangxi Normal University

Chinese Academy of Sciences

Yulin Normal University

University of Chinese Academy of Sciences

Institute of High Energy Physics

Huazhong University of Science and Technology

Sichuan University

Central South University

Sun Yat-sen University

Shanghai Jiao Tong University

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Oxoaporphine Metal Complexes (CoII, NiII, ZnII) with High Antitumor Activity by Inducing Mitochondria-Mediated Apoptosis and S-phase Arrest in HepG2

Scientific Reports (2017)

Jiao-Lan Qin Wen-Ying Shen Zhen‐Feng Chen Lifang Zhao Qi‐Pin Qin

Abstract Three new oxoaporphine Co(II), Ni(II) and Zn(II) complexes 1 – 3 have been synthesized and fully characterized. 1 – 3 have similar mononuclear structures with the metal and ligand ratio of 1:2. 1 – 3 exhibited higher cytotoxicity than the OD ligand and cisplatin against HepG2, T-24, BEL-7404, MGC80–3 and SK-OV-3/DDP cells, with IC 50 value of 0.23−4.31 μM. Interestingly, 0.5 μM 1 – 3 significantly caused HepG2 arrest at S-phase, which was associated with the up-regulation of p53, p21, p27, Chk1 and Chk2 proteins, and decrease in cyclin A, CDK2, Cdc25A, PCNA proteins. In addition, 1 – 3 induced HepG2 apoptosis via a caspase-dependent mitochondrion pathway as evidenced by p53 activation, ROS production, Bax up-regulation and Bcl-2 down-regulation, mitochondrial dysfunction, cytochrome c release, caspase activation and PARP cleavage. Furthermore, 3 inhibited tumor growth in HepG2 xenograft model, and displayed more safety profile in vivo than cisplatin.

10.1038/srep46056

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CCDC 2233913: Experimental Crystal Structure Determination

The Cambridge Structural Database (2023)

Ling-Qi Du Tian-Yu Zhang Xiaomei Huang Y. Xu Ming‐Xiong Tan

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

10.5517/ccdc.csd.cc2dzkqp

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CCDC 2281484: Experimental Crystal Structure Determination

The Cambridge Structural Database (2024)

Chun-Jie Liang Run-Chun Wu Xiaoqiong Huang Qi‐Pin Qin Hong Liang

10.5517/ccdc.csd.cc2gl28f

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Complexes of lanthanides(iii) with mixed 2,2′-bipyridyl and 5,7-dibromo-8-quinolinoline chelating ligands as a new class of promising anti-cancer agents

Metallomics (2019)

Qi‐Pin Qin Zhenfeng Wang Ming‐Xiong Tan Xiaoling Huang Hua‐Hong Zou

Abstract Five novel lanthanides(iii) complexes, [Lu(Me)(MBrQ)2NO3] (MeMBrQ-Lu), [Ho(MeO)(MBrQ)2NO3] (MeOMBrQ-Ho), [Ho(Me)(MBrQ)2NO3] (MeMBrQ-Ho), [La(Me)2(BrQ)2NO3] (MeBrQ-La) and [Sm(Me)(BrQ)2(CH3OH)NO3] (MeBrQ-Sm), have been synthesized, in which 2,2′-bipyridyl (4,4′-dimethyl-2,2′-bipyridyl (Me) and 4,4′-dimethoxy-2,2′-bipyridine (MeO)) and 5,7-dibromo-8-quinolinoline derivatives (5,7-dibromo-2-methyl-8-quinolinol (MBrQ-H) and 5,7-dibromo-8-quinolinol (BrQ-H)) act as the chelating ligands. The in vitro cytotoxic activities of the five Ln(iii) complexes have been studied with the SK-OV-3/DDP, NCI-H460 and HeLa cancer cells. MeMBrQ-Lu, MeOMBrQ-Ho, MeMBrQ-Ho, MeBrQ-La and MeBrQ-Sm show higher cytotoxicity against the HeLa cells (IC50 values of 1.00 nM–3.45 μM) than cisplatin (13.11 ± 0.53 μM). In particular, the MeOMBrQ-Ho and MeMBrQ-Ho complexes exhibit superior cytotoxic activity, with IC50 values at 1.00 ± 0.34 nM and 125.00 ± 1.08 nM. We further demonstrate that MeOMBrQ-Ho and MeMBrQ-Ho inhibit the proliferation of HeLa cells by inhibiting telomerase and targeting mitochondria to induce DNA damage-mediated apoptosis. In addition, MeOMBrQ-Ho significantly inhibits tumor growth with a tumor growth inhibition rate (IR) of 50.8% in a HeLa mouse xenograft model. Taken together, MeOMBrQ-Ho is a novel lanthanide(iii) complex with promising antitumor activity.

HeLa

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10.1039/c9mt00037b

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Synthesis, crystal structure, cytotoxicity and DNA interaction of 5,7-dibromo-8-quinolinolato-lanthanides

European Journal of Medicinal Chemistry (2012)

Yan‐Cheng Liu Zhen‐Feng Chen Xiaoyan Song Yan Peng Qi‐Pin Qin

10.1016/j.ejmech.2012.11.001

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Citations (52)

Three platinum(II) complexes of 2-(methoxy-phenyl)-imidazo-[4,5-f]-[1,10] phenanthroline: cell apoptosis induction by sub-G1 phase cell cycle arrest and G-quadruplex binding properties