Introduction: India has been subdivided in to two major regions with respect to a preference for or avoidance of consanguineous marriage. The deleterious health effects associated with consanguinity are caused by the expression of rare, recessive genes inherited from common ancestors. Objectives: To find out the prevalence and types of consanguinity and reproductive behaviour in rural area of Nagpur district. Methodology: study design: cross sectional study. Setting: Raipura village, a field practise area of Indira Gandhi Government Medical College, Nagpur. Study population: married couples. Result: The prevalence of consanguineous marriage in study couple was 16.43%. Most prevalent type of consanguineous marriage was seen in mother’s brother’s daughter type (73.04%). Significant association found in study couples and consanguinity in their parents. No significant effect of consanguinity was observed on foetal loss, neonatal mortality but significant association was found with congenital malformations.
Abstract Background: Thrombocytopenia is a frequent problem in neonatal sepsis and is among the most predictive, independent risk factors for sepsis-associated mortality. The present study was undertaken to correlate neonatal sepsis and thrombocytopenia in terms of severity, clinical course, organism specificity and outcome. Method: Total 384 neonates age <28 days with sepsis and thrombocytopenia were studied and analyzed with their clinical profile, symptoms, lab findings and outcomes. Results: Male babies (55.86%), age <72 hrs (80.35%), preterm (68.70%) and LBW babies (85.58%) were more prone to sepsis. Maternal fever (67.44%), foul smelling liquor (53.79%) and PROM >18 hrs (66.74%) make babies more prone to neonatal sepsis. The Commonest clinical features were not accepting feed (69.95%), lethargy (67.85%) and breathing difficulty (79.04%). Early onset sepsis (82.54%) and probable sepsis (40.26%) were more common and associated with preterm and LBW babies. Leucocytosis was seen in 64.57%, thrombocytopenia moderate degree 45.67% and severe degree 34.65%, MPV >12 69.11%, ANC <1800 47.50%, micro ESR >15 mm 72.16% and CRP positivity 28.60%. Severe degree thrombocytopenia (<50000) was more common with PROM >18 hrs (83.02%), maternal fever (83.09%) and gram-negative organism(61.29%). Leucopenia (<4000) was more common with maternal fever (75.79%), proven sepsis (43.16%) and gram-negative organism (70.31%). Severe degree thrombocytopenia (61.29%), leucopenia (70.31%) and mortality (64.51%) were more commonly associated with gram-negative organism. Outcome was bad with severe degree of thrombocytopenia (62.32%), leucopenia (73.91%), and gram-negative organism (64.51%). Conclusion: Proper antenatal mother care, hygiene and early evaluation for illness can prevent early onset of sepsis in neonates. Severity of degree of thrombocytopenia directly proportional to the worst outcome.
Background: Seizures represent the most distinctive signal of neurological disease in the newborn period and these convulsive phenomena are the most frequent of the overt manifestation of neonatal neurological disorders. Recognition and classification of seizures remain problematic; particularly when pediatricians rely only on clinical criteria. The objective of this study was to study the incidence of pediatrics (0-12 years) seizures. To study the etiology and pattern of seizures.Methods: 326 Subjects who had seizures were included in the study. Relevant history was ascertained from a patient’s parents or a reliable relative or attendant, medical records and the referring physicians note, specifically from mother in case of neonatal seizures i.e. age at onset of seizures, seizure activity with special emphasis on occurrence of 1st seizures, duration of seizures, number and type of seizures, associated autonomic changes, medications required to control seizures, response time to medications, and possible causes for determination of etiology. A detailed antenatal, natal and postnatal history was taken.Results: Out of 326 study subjects 117 (35.89%) were in neonatal age group, of which 75 (64.10%) and 42 (35.90%) were male and female respectively and 209 (64.11%) were beyond neonatal age, out of which 125 (59.8%) were male and 84 (40.2%) female. out of 117 neonatal seizures, 75 (64.10%) neonates were male and 42 (35.90%) were female. Male: Female ratio was 1.79:1. The seizures were common in male neonates. Subtle seizures were the commonest type of seizures observed both in term and preterm neonates.Conclusions: The various types of seizure were compared with the preterm and term neonates and it was found statistically significant (X2 = 5.06 d.f. = 4, p<0.05). The various causes of seizure were compared with the preterm and term neonates and it was found statistically significant (X2= 17.42 d.f. = 6 p<0.05).
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