Bruna Petry

Iowa State University

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

James E. Koltes

Iowa State University

Luiz Lehmann Coutinho

Universidade de São Paulo

Christine G. Elsik

University of Missouri

Theodore S. Kalbfleisch

University of Kentucky

Gabriel Costa Monteiro Moreira

University of Liège

Mirele Poleti

Universidade de São Paulo

Jonathan A. Green

University of Missouri

Sandra Coccuzzo Sampaio

Instituto Butantan

Brenda M. Murdoch

University of Idaho

Patrícia Akemi Assato

Kansas State University

Cooperative Institutions

Universidade de São Paulo

Instituto Butantan

Universidade Estadual Paulista (Unesp)

University of Missouri

Iowa State University

Agricultural Research Service

United States Department of Agriculture

Clinics Hospital of Ribeirão Preto

Universidade Brasil

Brazilian Agricultural Research Corporation

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

SAP30 Gene Is a Probable Regulator of Muscle Hypertrophy in Chickens

Frontiers in Genetics (2021)

Bruna Petry Gabriel Costa Monteiro Moreira Aline Gonçalves Lio Copola Marcela Maria de Souza Fernanda Cristina da Veiga

Animals with muscle hypertrophy phenotype are targeted by the broiler industry to increase the meat production and the quality of the final product. Studies characterizing the molecular machinery involved with these processes, such as quantitative trait loci studies, have been carried out identifying several candidate genes related to this trait; however, validation studies of these candidate genes in cell culture is scarce. The aim of this study was to evaluate SAP30 as a candidate gene for muscle development and to validate its function in cell culture in vitro. The SAP30 gene was downregulated in C2C12 muscle cell culture using siRNA technology to evaluate its impact on morphometric traits and gene expression by RNA-seq analysis. Modulation of SAP30 expression increased C2C12 myotube area, indicating a role in muscle hypertrophy. RNA-seq analysis identified several upregulated genes annotated in muscle development in treated cells (SAP30-knockdown), corroborating the role of SAP30 gene in muscle development regulation. Here, we provide experimental evidence of the involvement of SAP30 gene as a regulator of muscle cell hypertrophy.

Candidate gene

C2C12

10.3389/fgene.2021.709937

Cite

Citations (2)

RT2T: A Global Collaborative Project to Study Chromosomal Evolution in the Suborder Ruminantia

Research Square (Research Square) (2024)

Theodore S. Kalbfleisch Stephanie McKay Brenda M. Murdoch David L. Adelson Diego Almansa-Villa

Abstract The publication of the first complete, haploid telomere-to-telomere (T2T) human genome revealed new insights into the structure and function of the heretofore “invisible” parts of the genome including centromeres, tandem repeat arrays, and segmental duplications. Refinement of T2T processes now enables comparative analyses of complete genomes across entire clades to gain a broader understanding of the evolution of chromosome structure and function. The human T2T project involved a unique ad hoc effort involving many researchers and laboratories, serving as a model for collaborative open science. Subsequent generation and analysis of diploid, near T2T assemblies for multiple species represents a substantial increase in scale and would be daunting for any single laboratory. Efforts focused on the primate lineage continue to employ the successful open collaboration strategy and are revealing details of chromosomal evolution, species-specific gene content, and genomic adaptations, which may be general or lineage-specific features. The suborder Ruminantia has a rich history within the field of chromosome biology and includes a broad range of species at varying evolutionary distances with separation of tens of millions of years to subspecies that are still able to interbreed. We propose an open collaborative effort dubbed the “Ruminant T2T Consortium” (RT2T) to generate complete diploid assemblies for species in the Artiodactyla order, focusing on suborder Ruminantia. Here we present the initial near T2T assemblies of cattle, gaur, domestic goat, bighorn sheep, and domestic sheep, and describe the motivation, goals, and proposed comparative analyses to examine chromosomal evolution in the context of natural selection and domestication of species for use as livestock.

10.21203/rs.3.rs-3918604/v2

Cite

Citations (1)

The Divergent Pattern of SARS-CoV-2 Variant Predominance and Transmission Dynamics in the Brazilian Island of Ilhabela

Viruses (2022)

Vincent Louis Viala Svetoslav Nanev Slavov Loyze Paola Oliveira de Lima Alex Ranieri Jerônimo Lima Gabriela Ribeiro

Our effort in SARS-CoV-2 genomic surveillance in Brazil has detected the Alpha Variant of Concern with a predominance higher than 75% in the population of Ilhabela island (São Paulo State) at a time when the Gamma VOC was already predominating the mainland raised concerns for closer surveillance on this island. Therefore, we intensified the surveillance for 24 weeks by generating data from 34% of local positive cases. Our data show that the patterns of VOC predominance dynamics and infection rates were in general distinct from the mainland. We report here the first known case of Alpha predominance in a Brazilian population, a delay greater than 3 months for the Gamma to dominate the previous variants compared to the mainland, and a faster dispersion rate of Gamma and Delta VOCs compared to the mainland. Phylogenetic analysis revealed the SARS-CoV-2 transmission dynamics in Ilhabela were characterized by multiple independent introduction events of Gamma and Delta, with a few events of Alpha introduction, two of them followed by community transmission. This study evidenced the peculiar behavior of SARS-CoV-2 variants in an isolated population and brought to light the importance of specific programs for SARS-CoV-2 genomic surveillance in isolated populations.

Mainland

10.3390/v14071481

Cite

Citations (4)

Investigation for high-impact SNPs on important genes for muscle growth characteristics in broilers.

Bruna Petry Gabriel Costa Monteiro Moreira Erika Cristina Jorge M. C. Ledur Luiz Lehmann Coutinho

Source

Cite

Citations (0)

ERA DA EDIÇÃO GÊNICA: APLICAÇÕES E FUTURO

Instituto de Inteligência em Pesquisa e Consultoria Cientifica Ltda eBooks (2022)

Bruna Petry Gabriel Costa Monteiro Moreira

Genes e mutações causadoras de doenças genéticas são uma preocupação para a qualidade de vida dos seres humanos, uma vez que, para a maioria delas, ainda não existe cura ou tratamento eficaz para amenizar os sintomas. Estudos utilizando tecnologias capazes de editar ou modificar a sequência dos genes vem sendo publicados. Recentemente, uma nova tecnologia capaz de cortar o DNA, inserir novas informações, ou até mesmo excluí-las, foi descoberta. Conhecida como CRISPR/Cas9, essa técnica possibilita a edição ou modificação do genoma de qualquer organismo: humano, animal, vegetal ou bactérias. Diversos estudos relacionados ao uso de CRISPR/Cas9 para a edição de genes e mutações em modelos animais já foram publicados. Para humanos, os estudos baseiam-se em identificação e edição de mutações causadoras de doenças genéticas. Essa revisão aborda alguns desses estudos, trazendo também exemplos da aplicação da técnica CRISPR/Cas9 no tratamento de doenças genéticas em seres humanos

10.56041/9786599841804-2

Cite

Citations (0)

Data reuse in agricultural genomics research: challenges and recommendations

GigaScience (2025)

Alenka Hafner Victoria L. DeLeo Cecilia Deng Christine G. Elsik Damarius S. Fleming

The scientific community has long benefited from the opportunities provided by data reuse. Recognizing the need to identify the challenges and bottlenecks to reuse in the agricultural research community and propose solutions for them, the data reuse working group was started within the AgBioData consortium framework. Here, we identify the limitations of data standards, metadata deficiencies, data interoperability, data ownership, data availability, user skill level, resource availability, and equity issues, with a specific focus on agricultural genomics research. We propose possible solutions stakeholders could implement to mitigate and overcome these challenges and provide an optimistic perspective on the future of genomics and transcriptomics data reuse.

10.1093/gigascience/giae106

Cite

Citations (1)

RT2T: A Global Collaborative Project to Study Chromosomal Evolution in the Suborder Ruminantia

Research Square (Research Square) (2024)

Theodore S. Kalbfleisch Stephanie McKay Brenda M. Murdoch David L. Adelson Diego Almansa-Villa

Ecomorphology

10.21203/rs.3.rs-3918604/v1

Cite

Citations (2)

New genes involved in the Bacterial Chondronecrosis with Osteomyelitis in commercial broilers

Livestock Science (2017)

Bruna Petry Igor Ricardo Savoldi A. M. G. Ibelli Ediane Paludo J. de O. Peixoto

Epiphysis

Candidate gene

10.1016/j.livsci.2017.12.003

Cite

Citations (14)

Dietary fatty acids applied to pig production and their relation to the biological processes: A review

Livestock Science (2022)

Simara Larissa Fanalli Bruna Pereira Martins da Silva Bruna Petry Miguel Henrique de Almeida Santana G.H.G. Polizel

Nutrigenomics

Biological value

10.1016/j.livsci.2022.105092

Cite

Citations (12)

An Overview of Viruses Transmitted by Water and Food

CRC Press eBooks (2023)

Aline Viancelli Bruna Petry William Michelon

Virus discovery changed the way we see nature. From the first studies reporting the existence of a contagium vivum fluidum to those reporting the occurrence of pathogens that are able to spread through vegetables, water and wastewater, a lot of efforts have been made to understand and eliminate the diseases related to these viruses: the waterborne diseases. These efforts include the improvement of the sample's concentration methods and the virus' detection tools (cellular and molecular). The enteric viruses are the group of pathogens responsible for this contamination, and for the majority of the deaths in children below 5 years old. Considering the importance of this issue, this chapter brings an overview about the facts, discoveries and scientists that wrote the environmental virology history. In a brief report, the fantastic and scarring world of viruses is explored, with a final purpose of motivating research about the abundant possibilities of knowledge of the most abundant group of organisms on earth.

10.1201/9781003263494-1

Cite

Citations (0)