Xiaochuang Liu

Anhui University of Traditional Chinese Medicine

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Hui Jiang

Anhui University of Traditional Chinese Medicine

Yang Han

Dalian University of Technology

Yongzhong Wang

Anhui University

Hongfei Wu

Anhui University of Traditional Chinese Medicine

An Zhou

Anhui University of Traditional Chinese Medicine

Juanjuan Jiang

Chinese Academy of Medical Sciences & Peking Union Medical College

Mengyu Su

Anhui University of Traditional Chinese Medicine

Jiarong Gao

Anhui University of Traditional Chinese Medicine

Rong Huang

Tianjin Economic-Technological Development Area

Yitung Chen

University of Nevada, Las Vegas

Cooperative Institutions

Anhui University of Traditional Chinese Medicine

Harbin Engineering University

Peking University

Chinese Academy of Sciences

Anhui Medical University

Anhui University

State Administration of Traditional Chinese Medicine of the People's Republic of China

Ministry of Education of the People's Republic of China

Fudan University

Sichuan University

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An Adaptive Optimal Control Algorithm for Jet Pipe Electro-hydraulic Servo Valve

Xiaochuang Liu Rui Wang Tao Sun Xian Du

In this paper, an adaptive optimal controller design method is proposed for the jet pipe electro-hydraulic servo valve. By establishing the dynamic model of the electro-hydraulic servo valve, the state variables and control variables are selected and transformed into the solution of the optimal control problem. Then based on adaptive dynamic programming (ADP) technology, which uses the state and online input information to iteratively solve the algebraic Riccati equation, the optimal control problem of the electro-hydraulic servo valve is solved. Finally, a simulation is given to demonstrate the effectiveness of the method in solving the optimal control problem of the electro-hydraulic servo valve of the jet tube.

Electrohydraulic servo valve

Algebraic Riccati equation

Servomechanism

10.23919/chicc.2019.8865709

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Citations (3)

Network pharmacology approach and molecular docking to explore the potential mechanism of Wu-Wei-Wen-Tong Chubi capsules in rheumatoid arthritis

Naunyn-Schmiedeberg s Archives of Pharmacology (2022)

Xiaoya Cui Jian Liu Lili Zhang Xiaoli Wang Xiaochuang Liu

Systems pharmacology

KEGG

Docking (animal)

10.1007/s00210-022-02260-0

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Citations (9)

[Wuwei Wentong Chubi Capsule promotes the autophagy in synovial tissue of adjuvant-induced arthritis rats and its mechanism].

PubMed (2017)

Hui Jiang Xiaochuang Liu Xiujuan Qin Song Jun-mei Jian Liu

Objective To evaluate the effect of Wuwei Wentong Chubi (WWWTCB) Capsule on the PI3K/AKT/mTOR signaling pathway in the synovial tissues of adjuvant-induced arthritis (AA) rats, and investigate its potential pharmacological mechanisms of treating rheumatoid arthritis. Methods Sixty Sprague Dawley (SD) rats were randomly assigned into six groups evenly: normal group, model group, WWWTCB groups at 0.80, 1.60, 3.20 g/kg body mass, and tripterygium glycosides tablet (TPT) group at 40 mg/kg body mass. Except for the normal group, the other five groups were induced into AA models with Complete Freund's Adjuvant (CFA). The WWWTCB or TPT, was administrated from day 12 after injection of CFA by gavage, once a day for 12 days. After that, unaffected ankle-joint tissues from the AA rats were collected for histopathological examination. The mRNA levels of PI3K, AKT, mTOR, p70s6 and beclin1 in the synovial tissue were detected by real-time quantitative PCR. Meanwhile, the protein levels of PI3K, AKT, p-AKT, mTOR, p-mTOR, p70s6, p-p70s6 and beclin1 were determined by immunofluorescence histochemical staining and/or Western blotting. Results Compared with the model group, WWWTCB (1.60, 3.20 g/kg body mass) groups showed less ankle-joint injury and decreased proliferation of synovial cells in the ankle-joint tissues. In addition, the administration of WWWTCB decreased the mRNA and protein levels of PI3K, AKT, p-AKT, mTOR, p-mTOR, p70s6 and p-p70s6, while increased the level of beclin1. Conclusion WWWTCB ameliorated AA in rats. The improvement might be closely related to the inhibitory effect of WWWTCB on the PI3K/AKT/mTOR signaling pathway and its promoting effect on the autophagy activity of synovial cells.

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DFT characterization of a new possible two-dimensional BN allotrope with a biphenylene network structure

Physical Chemistry Chemical Physics (2023)

Yang Han Tingxiang Hu Xiaochuang Liu Shijie Jia Hangbing Liu

The pioneering work on the newly experimentally synthesized biphenylene network C has triggered a worldwide tide of research on its family material counterparts. In this study, a biphenylene network BN structure was theoretically characterized by density functional theory (DFT) calculations. Initially, the structure's mechanical and thermal stabilities were evaluated. There were no imaginary frequencies in the phonon dispersion curve, indicating that the structure was mechanically stable. Additionally, the energy barrier for forming a biphenylene network BN structure from perfect pristine 2D h-BN is substantially less than that for forming a biphenylene network C from a perfect graphene sheet, as can be explained from the greater structure distortion in the biphenylene network BN with lower bond stress which thus caused lower energy. The electronic band structure and detailed projected density of states analysis indicated that the biphenylene network BN is a semiconductor with the valence band maximum (VBM) and the conduction band minimum (CBM) states from the pz orbitals of N and B atoms with sp2 hybridization. Finally, a bilayer structure was also proposed. Our obtained results provide more insights into two-dimensional biphenylene network BN based structures and those family materials which could be widely used in relevant nanoelectronic devices.

Biphenylene

10.1039/d2cp05995a

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A microemulsion high-performance liquid chromatography (MELC) method for the separation and determination of hydrolyzed tenuifolin in Radix Polygalae

Scientific Reports (2019)

Hui Yan Zhuan-Di Zheng Hongfei Wu Xiaochuang Liu An Zhou

Tenuifolin was used as a reliable chemical marker for the quality control of Radix Polygalae. The determination of tenuifolin is challenging because the analyte molecule lacks a suitable chromophore. The aim of this study was to establish a microemulsion high-performance liquid chromatography (MELC) method which is robust and sensitive, and can separate and determine tenuifolin in Radix Polygalae using an oil-in-water (O/W) microemulsion mobile phase. The separations were performed on a C18 (4.6 × 250 mm, 5 μm) column at 25 °C using a flow rate of 1.0 mL/min, and an ultraviolet detection wavelength of 210 nm. The microemulsion mobile phase comprised 2.8% (w/v) sodium dodecyl sulfate (SDS), 7.0% (v/v) n-butanol, 0.8% (v/v) n-octane and 0.1% (v/v) aqueous orthophosphate buffer (H3PO4). The linearity analysis of tenuifolin showed a correlation coefficient of 0.9923 in the concentration range of 48.00-960.00 µg/mL. The accuracy of the method based on three concentration levels ranged from 96.23% to 99.28%; the limit of detection (LOD) was 2.34 µg/mL, and the limit of quantification (LOQ) was 6.76 µg/mL. The results of our study indicated that the optimized MELC method was sensitive and robust, and can be widely applied for the separation and determination of tenuifolin in Radix Polygalae.

Microemulsion

Radix (gastropod)

10.1038/s41598-019-55416-z

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Citations (2)

Research on performance testing model of databases of different structure

Xiaochuang Liu

10.23977/meet.2019.93719

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Citations (0)

Metabolic profiling of copper-laden hepatolenticular degeneration model rats and the interventional effects of Gandou decoction using UPLC-Q-TOF/MS

Journal of Pharmaceutical and Biomedical Analysis (2018)

Meimei Cheng Huan Wu Hongfei Wu Xiaochuang Liu An Zhou

Metabolic pathway

Decoction

10.1016/j.jpba.2018.10.041

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Citations (16)

Rapid identification of chemical profile in Gandou decoction by UPLC-Q-TOF-MSE coupled with novel informatics UNIFI platform

Journal of Pharmaceutical Analysis (2019)

Li Xu Yi Liu Hongfei Wu Huan Wu Xiaochuang Liu

Gandou decoction (GDD), a well-known traditional Chinese medicine (TCM) formula, has been widely used for decades to treat Wilson's disease (WD) in China due to its remarkable clinical effects. However, the chemical constituents of GDD still remain unclear because of their complexity. In this work, a reliable and sensitive strategy based on ultra-performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry (UPLC-Q-TOF-MSE) and UNIFI informatics platform was applied to investigate the chemical components in GDD. In total, 96 compounds including anthraquinones, alkaloids, protostane triterpenoids, flavonoids, triterpenoid saponins, tannins, curcuminoids, etc, were identified or tentatively characterized from GDD by comparing their retention time, accurate mass within 5 ppm error and MSE fragmentation patterns. Among them, eleven compounds were confirmed unambiguously with reference standards. Representative compounds in different chemical structure types were analyzed in fragmentation patterns and characteristic ions. Moreover, to better understand the chemical contribution of individual herbs to the whole decoction, the corresponding each herb in GDD was also detected. This study developed a rapid method for characterizing the chemical constituents in GDD, which could not only be used for chemical standardization and quality control, but also be helpful for further research of GDD in vivo.

Decoction

10.1016/j.jpha.2019.05.003

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Citations (65)

Stretched three-dimensional white graphene with a tremendous lattice thermal conductivity increase rate

RSC Advances (2022)

Yang Han Yue Liang Xiaochuang Liu Shijie Jia Chaoxiang Zhao

Thermal conductivity of the 3D h-BN honeycomb structure increases by 7.2 times under strain compared to an increase of only 0.67 times in the strained 3D graphene counterpart, differing from behaviors of traditional bulk diamond or silicon.

Lattice (music)

10.1039/d2ra01869a

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Citations (3)

[Effect of Panax notoginseng saponins on cytokines in liver fibrosis rats].

PubMed (2013)

Hui Jiang Yongzhong Wang Xiaochuang Liu Xue Xue

To observe the effect of Panax notoginseng saponins (PNS) on cytokines production in liver fibrosis rats and its mechanism.SD rats were randomly divided into 6 groups, including normal group, liver fibrosis model group, PNS (50, 100, 200 mg/kg) treated groups and Col group. Rat liver fibrosis was induced by CCl4 twice a week for 18 weeks. PNS were administered daily from the 9th week for 10 weeks. The IL-1, IL-6, IL-10, TNF-alpha level in serum were determined by radioimmunity. The degree of liver fibrosis was observed by HE and immuninochemistry. The expression of TGF-beta, TNF-alpha mRNA were detected by RT-PCR technology.Compared with the fibrotic model group, PNS (100, 200 mg/kg) could not only significantly reduce histopathological change, but also effectively decrease the level of IL-1, IL-6, NF-kappaB, TNF-alpha ,TGF-beta, and increase the level of IL-10.PNS has protective effect on liver fibrosis and it maybe related to regulating cytokine network.

Panax notoginseng

CCL4

Hepatic fibrosis

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Citations (4)