Zui Zhang

Anhui University

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Jianguo Chen

Huazhong University of Science and Technology

Fang Wang

Chinese Academy of Sciences

Kenji Kadomatsu

Nagoya University

Li‐Hong Long

Huazhong University of Science and Technology

Massimo Piccardi

University of Technology Sydney

Kenji Uchimura

Université de Lille

Xin‐Lei Guan

Wuhan Puai Hospital

Yuan‐Jian Yang

Jiangxi Mental Health Center

Yoshiko Takeda‐Uchimura

Unité de Glycobiologie Structurale et Fonctionnelle

Pengfei Wu

Shanghai Medical College of Fudan University

Cooperative Institutions

Huazhong University of Science and Technology

Fudan University

Chinese Academy of Sciences

Nagoya University

Shanghai Jiao Tong University

Ministry of Education of the People's Republic of China

Anhui Medical University

Sichuan University

National Center for Geriatrics and Gerontology

Xi'an Jiaotong University

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Tracking people under heavy occlusions by layered data association

Multimedia Tools and Applications (2014)

Zui Zhang Oscar Perez‐Concha Massimo Piccardi

BitTorrent tracker

Tracking (education)

Association (psychology)

Data association

Feature (linguistics)

Tracking system

10.1007/s11042-014-1979-1

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Citations (2)

A specific and rapid colorimetric method to monitor the activity of methionine sulfoxide reductase A

Enzyme and Microbial Technology (2013)

Pengfei Wu Zui Zhang Xin‐Lei Guan Yuanlong Li Jianhua Zeng

MSRA

Methionine sulfoxide

Methionine sulfoxide reductase

Dithiothreitol

10.1016/j.enzmictec.2013.08.005

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Citations (20)

Determination of protein-bound methionine oxidationin the hippocampus of adult and old rats by LC-ESI-ITMS method after microwave-assisted proteolysis

Analytical and Bioanalytical Chemistry (2011)

Li‐Hong Long Pengfei Wu Xin‐Lei Guan Jun-Qi Zhang You Jin

Methionine sulfoxide

Proteolysis

10.1007/s00216-010-4604-9

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Citations (11)

GlcNAc6ST3 is a keratan sulfate sulfotransferase for the protein-tyrosine phosphatase PTPRZ in the adult brain

Scientific Reports (2019)

Narentuya Yoshiko Takeda‐Uchimura Tahmina Foyez Zui Zhang Tomoya O. Akama

Abstract Keratan sulfate (KS) is a carbohydrate side chain covalently attached to extracellular proteoglycans. KS is composed of disaccharide units of 6-sulfated N -acetylglucosamine (GlcNAc) and galactose. We have previously shown that GlcNAc-6- O -sulfotransferase (GlcNAc6ST) 1 encoded by Chst2 is an enzyme necessary for the synthesis of GlcNAc-6-sulfated KS chains that are required for neuronal plasticity in the visual cortex of the mouse brain during the critical period, but not in adulthood. Here, we show that GlcNAc-6-sulfated KS recognized by the R-10G anti-KS antibody, of which the minimum epitope structure is Galß1-4GlcNAc(6S)ß1-3Galß1-4GlcNAc(6S), distributes diffusely in neuropils and presents densely in close proximity to the perineuronal region of the perineuronal net (PNN)-positive neurons in the adult visual cortex. Surprisingly, GlcNAc6ST3, which was discovered as an intestinal GlcNAc6ST encoded by Chst5 , is a major brain KS sulfotransferase expressed in oligodendrocytes in adulthood. Moreover, we identified an isoform of the protein-tyrosine phosphatase PTPRZ as a R-10G-reactive KS proteoglycan. These results indicate that GlcNAc6ST3 may play a role in synthesis of a component of PNN in the adult brain, and that the KS-modified isoform of PTPRZ encoded by Ptprz1 could be an extracellular molecule associated with PNNs.

Perineuronal net

Keratan sulfate

Sulfotransferase

10.1038/s41598-019-40901-2

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Citations (21)

Orexin-A Activates Hypothalamic AMP-Activated Protein Kinase Signaling through a Ca²⁺-Dependent Mechanism Involving Voltage-Gated L-Type Calcium Channel

Molecular Pharmacology (2013)

Wen‐Ning Wu Pengfei Wu Jun Zhou Xin‐Lei Guan Zui Zhang

Hypothalamic AMP-activated protein kinase (AMPK) and orexins/hypocretins are both involved in the control of feeding behavior, but little is known about the interaction between these two signaling systems. Here, we demonstrated that orexin-A elicited significant activation of AMPK in the arcuate nucleus (ARC) of the hypothalamus by elevating cytosolic free Ca²⁺ involving extracellular calcium influx. Electrophysiological results revealed that orexin-A increased the L-type calcium current via the orexin receptor-phospholipase C-protein kinase C signaling pathway in ARC neurons that produce neuropeptide Y, an important downstream effector of orexin-A's orexigenic effect. Furthermore, the L-type calcium channel inhibitor nifedipine attenuated orexin-A-induced AMPK activation in vitro and in vivo. We found that inhibition of AMPK by either compound C (6-[4-[2-(1-piperidinyl)ethoxy]phenyl]-3-(4-pyridinyl)-pyrazolo[1,5-a]pyrimidine) or the ATP-mimetic 9-β-D-arabinofuranoside prevented the appetite-stimulating effect of orexin-A. This action can be mimicked by nifedipine, the blocker of the L-type calcium channel. Our results indicated that orexin-A activates hypothalamic AMPK signaling through a Ca²⁺-dependent mechanism involving the voltage-gated L-type calcium channel, which may serve as a potential target for regulating feeding behavior.

Orexin-A

L-type calcium channel

10.1124/mol.113.086744

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Citations (41)

Z-number Decision Tree and Its Appliction

Research Square (Research Square) (2023)

Yue Fang Tom Wu Shuai Liu Zui Zhang

Abstract Fuzzy decision tree(FDT) is an expansion and improvement of decision tree, which expands the application scope of decision tree to deal with the uncertainty and extracts classification rules efficiently. However, there are some problems in the process of sample attributes fuzzifying, such as information loss and the influence of strong personal subjectivity on the results. To solve these problems, a fuzzy decision tree algorithm based on Z-number(Z-FDT) is put forward. we propose a method to construct Z-number, first, membership functions is defined to fuzzify the data set and describe the size of the probability measure of the fuzzy set, then the cluster centers of multi-dimensional data are extracted ,using the fuzzy clustering algorithm., the membership function and cluster centers of different categories fuzzy partition the sample data set based on the features of the sample, and obtain the fuzzy sets. Finally, based on the definition of Z-number, fuzzy sets are constructed into Z-numbers. After the multidimensional data set is transformed into Z-numbers, the uncertainty measure of Z-number is used to select appropriate features to partition the data set, until the stop condition is met. Z-FDT can directly classify and predict samples with continuous attribute values, and has good generalization ability and relatively stable results, at the last, this will be confirmed through the comparative experiment with ID3, Cart and Fuzzy ID3.

Defuzzification

10.21203/rs.3.rs-2475473/v1

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An accurate algorithm for head detection based on XYZ and HSV hair and skin color models

Zui Zhang Hatice Güneş Massimo Piccardi

Head detection in images and videos plays an important role in a wide range of computer vision and multimedia applications. In this paper, we propose a new head detection algorithm that is capable of handling significantly variable conditions in terms of viewpoint (i.e. frontal, profile, back view, from −180 degrees to +180 degrees), tilt angle (i.e. from horizontal to aerial), scale and resolution. To this aim, we built a new model for the head based on appearance distributions and shape constraints. The appearance distribution models the colors of hair and skin by sets of Gaussian mixtures in the XYZ and HSV color spaces. The shape constraint fits an elliptical model to the candidate region and compares its parameters with priors based on the human anatomy. This presents a pixel-level measurement of accuracy for the proposed algorithm both prior and after applying the spatial constraints referenced by the elliptical model. The excellent accuracy at both levels confirms the accuracy of the appearance model and the appropriateness of the spatial and topological process.

Gaussian network model

10.1109/icip.2008.4712087

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Citations (19)

Compositional analysis of the glycosaminoglycan family in velvet antlers of Sika deer (Cervus nippon) at different growing stages

Glycoconjugate Journal (2019)

Naoko Takeda‐Okuda Shuji Mizumoto Zui Zhang Soo‐Ki Kim Chi-Ho Lee

Dermatan sulfate

Keratan sulfate

Cervus

Velvet

10.1007/s10719-019-09859-1

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Citations (8)

Arming Anti-EGFRvIII CAR-T With TGFβ Trap Improves Antitumor Efficacy in Glioma Mouse Models

Frontiers in Oncology (2020)

You Li Huifang Wu Gang Chen Xiaofan Wei Chunyu Wang

Glioblastoma (GBM) is an aggressive malignancy with poor prognosis. New treatment and therapy strategy for GBM are urgently needed. Although clinical studies have demonstrated the feasibility and safety of chimeric antigen receptor (CAR) T cell therapy for GBM, the efficacy have not been that impressive. The major limit for anti-tumor efficacy of CAR-Ts is immunosuppressive milieu of GBM tumor microenvironment (TME). TGFβ, a substantial component in GBM, compromises immune response and contributes to the immune evasion and tumor progression. To overcome the limitation and improve the efficacy of CAR-T cells for GBM, we optimized the EGFRvIII-specific CAR construct with TGFRII ectodomain as a TGFβ-trap and generated TGFβ-resistant CAR-Ts for GBM therapy. We demonstrated that this TGFβ-trapped architecture enhanced anti-tumor efficacy of EGFRvIII-specific CAR-T and prolonged the survival of mice bearing GBM. In addition, the GBM-infiltrated microglia, typically considered tumorigenic, showed increased expression of M1 polarization markers in TGFβ-trap CAR-Ts group, indicating that these microglia were polarized towards pro-inflammatory and anti-tumorigenic phenotype. Overall, these results indicated that arming with TGFβ-trap and diminishing the immunosuppressive effect is a potential strategy to improve CAR-T efficacy for GBM therapy.

10.3389/fonc.2020.01117

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Citations (30)

Contributors

Elsevier eBooks (2018)

Rujing Chen Saurabh Dhanda Jiajun Fan Huile Gao Xiaoling Gao

10.1016/b978-0-12-814001-7.09995-9

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