Serghei Covanțev

Botkin Hospital

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Co-Authors

Alexandru Corlăteanu

Nicolae Testemițanu State University of Medicine and Pharmacy

Olga Belic

Nicolae Testemițanu State University of Medicine and Pharmacy

Victor Botnaru

Nicolae Testemițanu State University of Medicine and Pharmacy

Natalia Mazuruc

Nicolae Testemițanu State University of Medicine and Pharmacy

D.D. Dolidze

Botkin Hospital

Olga Corlateanu

Nicolae Testemițanu State University of Medicine and Pharmacy

Rasul Uzdenov

North Caucasian State Academy

Nikolaos M. Siafakas

University of Crete

Eugenia Scutaru

Nicolae Testemițanu State University of Medicine and Pharmacy

Doina Rusu

Phthisiopneumology Institute "Chiril Draganiuc"

Cooperative Institutions

Botkin Hospital

City Clinical Hospital

Russian Medical Academy of Continuous Professional Education

Ministry of Health of the Russian Federation

Nicolae Testemițanu State University of Medicine and Pharmacy

Sechenov University

Grigore T. Popa University of Medicine and Pharmacy

Spitalul Clinic Judeţean de Urgenţe "Sf. Spiridon" Iaşi

P.A. Hertzen Moscow Oncology Research Institute

Russian Academy of Sciences

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An Overview of the Physiological and Pathological Role of Mast Cells in the Central Nervous System

Iberoamerican Journal of Medicine (2020)

Serghei Covanțev

Neurological disorders present a major group of diseases with the global prevalence of 6.3%. They are responsible for 12% global mortality. Mast cells are one of the most abundantly present cell of the immune system in the connective tissue and the central nervous system is not an exception. In this article is presented a review of studies on mast cells regarding their physiological role in cental nervous system. We also disscuss their role in several conditions like: multiple sclerosis, amyotrophic lateral sclerosis, Alzheimer’s disease, neuropsychiatric disorders, cerebrovascular disorders and central nervous system trauma, epilepsy, seizures and tumors. Finally, we evaluate whether they can be used as a targed for pharmaceutical treatment.

10.53986/ibjm.2021.0010

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Kimmerle Anomaly – An Important Anatomical Variation

Online Journal of Health and Allied Sciences (2018)

Serghei Covanțev

Anomaly (physics)

Variation (astronomy)

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Prevalence and Burden of Comorbidities in Obstructive Sleep Apnea Syndrome

Victoria Sircu Silvia Colesnic Serghei Covanțev Olga Corlateanu А. S. Sukhotko

Repeated desaturation of oxyhemoglobin, micro-arousals, which are typical in obstructive sleep apnea syndrome (OSAS), have negative effects on the health of patients, leading to a wide range of complications such as cardiovascular (arterial hypertension, pulmonary hypertension, chronic heart failure, arrhythmias, myocardial infarction) cerebrovascular (strokes), metabolic (insulin resistance, obesity, diabetes mellitus, metabolic syndrome), gastrointestinal (non-alcoholic liver disease), urinary (chronic renal failure), neuropsychiatric complications and a wide range of malignancies. This in turn has a multilateral effect on familial, occupational and social life, as well as increasing the risk of road traffic accidents or accidents at workplace. Awareness, timely screening and prevention of complications play an important role in the diagnosis and treatment of comorbid conditions. This review focuses on comorbidities in OSAS and the effect of CPAP therapy on their prognosis.

10.20944/preprints202305.0865.v1

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Beaver tail liver: an incidental but crucial anatomical variation in case of acute abdomen

Iberoamerican Journal of Medicine (2023)

Serghei Covanțev I. N. Lebedinsky Diana Slepuhkova Maria Kovaleva Karina Mulaeva

Variation (astronomy)

Acute abdomen

10.53986/ibjm.2023.0008

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Stepwise management of locally advanced gastric cancer, complicated by recurrent hemorrhage, in the conditions of multi-specialty hospital

International Medicine (2020)

А. В. Шабунин Dmitrii Grekov I. Yu. Korzheva Z. А. Bagateliya Victor Yakomaskin

Specialty

10.5455/im.83133

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The possible use of C-peptide in type I diabetes

Analele Ştiinţifice ale USMF „N. Testemiţanu” (2013)

Serghei Covanțev

(Scientific Advisor – MD, Associate Professor Elena Rivneac) Department of Biochemistry and Clinical Biochemistry, USMF “Nicolae Testemiţanu”

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The impact of probiotic bacteria on helicobacter pylori

International Medicine (2020)

Florea Natalia Maria Timoşco Emilia Behta Greta Bălan Serghei Covanțev

The prevalence of Helicobacter pylori (H. pylori) infection is 22-95% in the developing countries and 1-58% in the developed. It varies by geographic location, ethnicity, socioeconomic status, and age. H. pylori is considered an etiologic factor for the development of multiple conditions like peptic ulcer disease, gastric adenocarcinoma, and MALT lymphoma and possibly type 2 diabetes mellitus, chronic obstructive bronchitis, acute coronary disease, end-stage renal disease. The recommended treatment regimen for H. pylori is the standard triple therapy with a proton pump inhibitor (or ranitidine, bismuth citrate), with clarithromycin and amoxicillin or metronidazole. Nevertheless, since the 90’s the eradication rate of these triple regimens has decreased from 90% to 70%, due to H. pylori resistance to key antibiotics, mainly clarithromycin, but also metronidazole and levofloxacin. In two series of experiments, the effect of bacteria of H. pylori on the body's health was studied against the background of the targeted use of microorganisms with probiotic potential.

10.5455/im.112421

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Efficiency of different multidimensional indexes for the assessment of the risk of exacerbations in patients with COPD

05.02 - Monitoring airway disease (2020)

Alexandru Corlăteanu Eugenia Scutaru Doina Rusu Olga Corlateanu Serghei Covanțev

Background: COPD is a mainly chronic respiratory disease, a great number of patients suffer from exacerbations, which are defined as an acute worsening of respiratory symptoms requiring a change in treatment. Exacerbations are an important medical and healthcare problem at the global level. The aim of the study was to compare the efficiency of different multidimensional indexes for the assessment of the risk of exacerbations in patients with COPD. Methods: The study was conducted in 433 patients with COPD. Spirometric data were analyzed (FEV1, FVC, FEV1/FVC). Were applied different multidimensional indexes: BODE, e-BODE, BODEx, ADO, DOSE and CODEX. Results: The cohort consisted of 433 COPD patients of which 352 (81%) men and 81 (19%) women with mean age 62,7 ± 9,8 years. The multidimensional index E-BODE demonstrated excellent discriminatory power for the assessment of the risk of exacerbations (E-BODE AUC 0.935). CODEX, BODEx and DOSE showed good discriminatory power (CODEX AUC – 0.836, BODEx AUC - 0.829, DOSE AUC - 0.825). While BODE and ADO underestimated the risk of COPD exacerbations (BODE AUC - 0.662 and ADO AUC - 0.613). Conclusions: Our analyses showed best discriminatory performance for the E-BODE index in patients with COPD for the assessment of the risk of exacerbations.

BODE index

10.1183/13993003.congress-2020.974

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Left-sided Gallbladder: An Unusual Intraoperative Finding

Zenodo (CERN European Organization for Nuclear Research) (2021)

Rasul Uzdenov Daria Turovets Kseniya Zabudskaya Serghei Covanțev

10.5281/zenodo.4746499

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Morphological Evaluation of the Splenic Artery, Its Anatomical Variations and Irrigation Territory

Life (2023)

Serghei Covanțev F. F. Alieva Karina Mulaeva Natalia Mazuruc Olga Belic

Background: Precise knowledge of the topographic features of the splenic artery and its branches in the hilum region is of practical interest due to the various interventions on the vessels of the spleen. Materials and methods: The anatomy of the spleen was studied by means of macroscopic dissection on 330 organ complexes, which were carefully documented and analyzed statistically. Results: The analysis of the splenic artery trajectory led to identification of four types: straight (43.03%), sinusoidal (27.58%), serpentine (20.91%) and alternating (8.48%). To assess the relation between the trajectory of the splenic artery and its branches we performed a chi square test. Sinuous or serpentine trajectory was associated with the presence of long splenic artery branches (dorsal pancreatic artery or the great pancreatic artery), X2 (2, N = 330) = 12.85, p = 0.001. The artery was located suprapancreatic in 70.30% of cases, anteropancreatic in 4.55%, the vessel had an intrapancreatic course in 14.85% and in 10.00% of cases the artery was located retropancreatic. The presence of inferior polar arteries was associated with a longer pancreas (Spearman’s correlation; r = 0.37; p = 0.037). In a multiple regression analysis, inferior polar arteries predicted the length of the pancreas although only a small number of cases could be explained by this model (R2 = 0.127, Adjusted R2 = 0.098; Betta = 0.357; t(330) = 2.091; p = 0.045). There were 30 (9.09%) cases of accessory spleens. Conclusions: The arterial supply of the spleen is highly variable in its trajectory, terminal branches, and relation to other organs. The splenic artery tends to be sinuous or serpentine in zones when a large artery branches off (e.g., the dorsal pancreatic or greater pancreatic artery). Multiple short branches tend to stabilize the trajectory of the splenic artery. Inferior polar arteries and accessory spleens contribute to the length of the pancreas, most likely due to increased vascular supply to the tail of the gland.

Hilum (anatomy)

Lumen (anatomy)

10.3390/life13010195

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Citations (5)