Gloria Taliani

It has been tested some diluted HBsAg and anti-HBs positive sera by modified ELISA test. We have found a correlation between HBsAg titer and spectrophotometric reading value and we have shown it in a curve. On the other hand, by neutralization of different dilutions of a RIA anti-HBs positive serum with different dilutions of a HBsAg positive serum we have carried out a checkboard and we have found that the best titer for neutralizing HBsAg is 30 ng/ml. This HBsAg has been called "standard". Using HBsAg "standard" we have tested 50 sera of hemophiliacs and we have found 1 HBsAg positive (2%) and 38 anti-HBs positive patients (76%).

Serial dilution

Standard curve

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Il ritrattamento dei pazienti con epatite cronica C non responsivi ad un precedente trattamento

Gloria Taliani Elisa Biliotti

Treatment of chronic hepatitis C during the past years has shown a significant increase of the percentage of therapeutic response, mostly due to the availability of pegylated interferons. Nevertheless a proportion of patients, ranging from 15% to 60%, do not achieve the virus eradication after treatment, largely depending on viral genotype. Retreatment of non responders is recommended in those patients who have been treated with non-pegylated interferon. In these patients, the rate of antiviral response to retreatment depends on genotype, viral load, degree of histological damage, ethnicity and metabolic conditions, but also on patients' adherence to the therapy schedule. The probability of a sustained virological response after retreatment ranges from 8% to 26%. To improve the efficacy of retreatment, either interferon and/or ribavirin dosage have been increased, either other antiviral drugs have been added to combination therapy. Although these new strategies have produced variable results, they remain the cornerstone of retreatment in view of forthcoming new antiviral drugs.

Pegylated interferon

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Review.

PubMed (2007)

Gloria Taliani Elisa Biliotti

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Polyomavirus BK Infection Before Liver Transplantation in Patients With Chronic Kidney Disease

Transplantation Proceedings (2012)