Laura Soares Souto Lepesqueur

Universidade Estadual Paulista (Unesp)

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Cristiane Yumi Koga‐Ito

Universidade Estadual Paulista (Unesp)

Cinthia Gomes Yassuda

Universidade Estadual Paulista (Unesp)

Eliel Soares Orenha

Universidade de São Paulo

Symone Cristina Teixeira

Universidade Estadual Paulista (Unesp)

Eduardo Galera da Silva

Universidade Estadual Paulista (Unesp)

Rebéca Di Nicoló

Universidade Estadual Paulista (Unesp)

Viviane Maria Gonçalves de Figueiredo

Universidade Estadual Paulista (Unesp)

Liliane Maria Ferrareso Lona

Universidade Estadual de Campinas (UNICAMP)

Rubia F. Gouveia

Brazilian Center for Research in Energy and Materials

Gabriela de Morais Gouvêa Lima

Universidade Estadual Paulista (Unesp)

Cooperative Institutions

Universidade Estadual Paulista (Unesp)

Universidade Estadual de Campinas (UNICAMP)

Universidade de São Paulo

Fundação Faculdade de Odontologia

Instituto Tecnológico de Aeronáutica

Departamento de Ciência e Tecnologia

Prefeitura Municipal de Campos dos Goytacazes

Pontifícia Universidade Católica de Campinas

Fundação de Apoio à Universidade Federal de São Paulo

Brazilian Center for Research in Energy and Materials

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Sorria com saúde

Congresso de Extensão Universitária (2009)

Laura Soares Souto Lepesqueur Cinthia Gomes Yassuda Aline Vieira da Silva Carolina Lima de Oliveira Eduardo Galera da Silva

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Ellagic Acid–Cyclodextrin Complexes for the Treatment of Oral Candidiasis

Molecules (2021)

Aline da Graça Sampaio Aline Vidal Lacerda Gontijo Gabriela de Morais Gouvêa Lima Maria Alcionéia Carvalho de Oliveira Laura Soares Souto Lepesqueur

The increase in the prevalence of fungal infections worldwide and the rise in the occurrence of antifungal resistance suggest that new research to discover antifungal molecules is needed. The aim of this study was to evaluate the potential use of ellagic acid–cyclodextrin complexes (EA/HP-β-CD) for the treatment of oral candidiasis. First, the effect of EA/HP-β-CD on C. albicans planktonic cells and biofilms was evaluated. Then, the cytotoxicity of the effective concentration was studied to ensure safety of in vivo testing. Finally, the in vivo effectiveness was determined by using a murine model of induced oral candidiasis. Data was statistically analyzed. The minimal inhibitory concentration of EA/HP-β-CD was 25 µg/mL and a concentration of 10 times MIC (250 µg/mL) showed an inhibitory effect on C. albicans 48 h-biofilms. The complex at concentration 250 µg/mL was classified as slightly cytotoxic. In vivo experiments showed a reduction in fungal epithelial invasion after treatment with EA/HP-β-CD for 24 h and 96 h when compared to the negative control. In conclusion, the results demonstrated that EA/HP-β-CD has antifungal and anti-inflammatory effects, reducing the invasive capacity of C. albicans, which suggests that EA/HP-β-CD may be a promising alternative for the treatment of oral candidiasis.

Ellagic Acid

IC50

10.3390/molecules26020505

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Citations (19)

Coating Dental Implant Abutment Screws with Diamondlike Carbon Doped with Diamond Nanoparticles: The Effect on Maintaining Torque After Mechanical Cycling

The International Journal of Oral & Maxillofacial Implants (2015)

Laura Soares Souto Lepesqueur Viviane Maria Gonçalves de Figueiredo Leandro Ferreira Argemiro Soares da Silva Sobrinho M. Massi

To determine the effect of maintaining torque after mechanical cycling of abutment screws that are coated with diamondlike carbon and coated with diamondlike carbon doped with diamond nanoparticles, with external and internal hex connections.Sixty implants were divided into six groups according to the type of connection (external or internal hex) and the type of abutment screw (uncoated, coated with diamondlike carbon, and coated with diamondlike carbon doped with diamond nanoparticles). The implants were inserted into polyurethane resin and crowns of nickel chrome were cemented on the implants. The crowns had a hole for access to the screw. The initial torque and the torque after mechanical cycling were measured. The torque values maintained (in percentages) were evaluated. Statistical analysis was performed using one-way analysis of variance and the Tukey test, with a significance level of 5%.The largest torque value was maintained in uncoated screws with external hex connections, a finding that was statistically significant (P = .0001). No statistically significant differences were seen between the groups with and without coating in maintaining torque for screws with internal hex connections (P = .5476).After mechanical cycling, the diamondlike carbon with and without diamond doping on the abutment screws showed no improvement in maintaining torque in external and internal hex connections.

Diamond-like carbon

Abutment

Carbon fibers

Cycling

Temperature cycling

10.11607/jomi.3933

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Condição da saúde bucal de crianças atendidas pela sociedade beneficente São Mateus

Congresso de Extensão Universitária (2009)

Cinthia Gomes Yassuda Laura Soares Souto Lepesqueur

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Efeitos da fibrose cística sobre o microbioma bucal e o proteoma salivar

Laura Soares Souto Lepesqueur

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Silver nanoparticles coated with dodecanethiol used as fillers in non-cytotoxic and antifungal PBAT surface based on nanocomposites

Materials Science and Engineering C (2019)

Filipe V. Ferreira M. Marcos Laura Soares Souto Lepesqueur Ivanei Ferreira Pinheiro Laura Santos

Silver nanoparticle

10.1016/j.msec.2019.01.044

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Citations (45)

Evaluation of self-etching primer on bond strength in feldspathic ceramic

Research Society and Development (2021)

Nathalia Eduardo Sgrott Renata Bahia Accioly Lins Isaias Donizeti Silva Laura Soares Souto Lepesqueur Karina Andréa Novaes Olivieri

The aim of the study was to evaluate the effect of self-etching silane primer on long-term bonding strength on feldspathic ceramic. Ceramic blocks (IPS Empress CAD, Ivoclar Vivadent) were cut with a low-speed diamond disk (Isomet 1000, Buehler) into 40 blocks of 12x7x6mm, under water cooling, and randomly divided into two groups (n=20), according to the surface conditioning: hydrofluoric acid (HF) (Condac, FGM) or self-etching silane primer (MEP) (Monobond Etch and Prime, Ivoclar Vivadent). After the blocks were bonded to composite resin blocks (12 x 7 x 3mm) (Liss, FGM) with a light cured cement (Variolink Esthetic LC, Ivoclar Vivadent) and LED photoactivation (Radii Cal, SDI) for 40 s on each luting interface line. The sets were cut in sticks with 1-mm2 cross-section composed of ceramic/cement/composite and tested after 24h (baseline) and 90 days aging by stored in distilled water at 37ºC. Microtensile bond strength testing (mTBS) was performed using a universal machine (DL-1000, EMIC) submitted to traction with speed of 0.5mm/ min until rupture of adhesion. Fracture of specimens were examined under stereomicroscopy to determine the failure pattern. Bond strength (MPa) was calculated, and the failure pattern and interface topography were assessed using scanning electron microscopy (SEM). No significant different mTBS was observed between groups HF and MEP (p>0.05). Storage time of the samples did not affect the mTBS from the groups. Surface etching pattern with HF produced higher surface alterations than a self-etching primer. Application of MEP may be considered an alternative for silanization for feldspathic ceramic.

Primer (cosmetics)

Universal testing machine

Hydrofluoric acid

10.33448/rsd-v10i5.14572

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Disciplina de extra-muros: um nova vivência na formação acadêmica

Congresso de Extensão Universitária (2009)

Cinthia Gomes Yassuda Laura Soares Souto Lepesqueur Daniel Maranha da Rocha Eliel Soares Orenha Eduardo Galera da Silva

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Cellulose nanocrystal‐based poly(butylene adipate‐co‐terephthalate) nanocomposites covered with antimicrobial silver thin films

Polymer Engineering and Science (2019)

Filipe V. Ferreira M. Marcos Ivanei Ferreira Pinheiro Elisa M. Cazalini Diego H. S. Souza

In this study, we reported the preparation and prospective application of the nanocomposites of poly(butylene adipate‐co‐terephthalate) (PBAT) reinforced with cellulose nanocrystals (CNCs). CNCs were isolated from bleached sugarcane bagasse by acid hydrolysis and functionalized with adipic acid. Nanocomposites were prepared with different concentration of CNCs (0.8, 1.5, and 2.3 wt% CNC) by solution‐casting method and then were covered with silver thin film by magnetron sputtering. The results showed that the surface modification increased the degree of crystallinity of nanocrystals from 51% to 56%, decreasing their length and diameter. Moreover, AFM‐IR spectroscopy revealed that the modified CNCs were covered by adipic acid molecules, improving the dispersion of nanocrystals in PBAT. Well‐dispersed modified CNCs acted as heterogeneous nuclei for crystallization of PBAT, and increased the storage modulus of the polymer by more than 200%. These improvements in thermal and mechanical properties of CNC‐based PBAT associated with the decrease of 56% in the Escherichia coli biofilm formation on nanocomposites (antibacterial properties) qualify the CNC/PBAT nanocomposites covered with silver thin films to be used as food packaging. POLYM. ENG. SCI., 59:E356–E365, 2019. © 2019 Society of Plastics Engineers

Adipate

Adipic acid

10.1002/pen.25066

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Citations (42)

Efeito do recobrimento de filmes de carbono tipo diamante depositados a plasma na manutenção do torque de parafusos protéticos

Aleph UCLA Undergraduate Research Journal for the Humanities and Social Sciences (2014)

Laura Soares Souto Lepesqueur

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