Peng Zhou

Chinese Academy of Medical Sciences & Peking Union Medical College

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Hongbing Yan

Chinese Academy of Medical Sciences & Peking Union Medical College

Jinying Zhou

Chinese Academy of Medical Sciences & Peking Union Medical College

Hanjun Zhao

Chinese Academy of Medical Sciences & Peking Union Medical College

Runzhen Chen

Chinese Academy of Medical Sciences & Peking Union Medical College

Jiannan Li

Chinese Academy of Medical Sciences & Peking Union Medical College

Zhaoxue Sheng

Children's Hospital of Chongqing Medical University

Xiaoxiao Zhao

Zhejiang University

Li Song

Chinese Academy of Medical Sciences & Peking Union Medical College

Chen Liu

The First Affiliated Hospital, Sun Yat-sen University

Chen Liu

Yale University

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Chinese Academy of Medical Sciences & Peking Union Medical College

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Fu Wai Hospital

Air Force Medical University

Capital Medical University

Fudan University

Peking Union Medical College Hospital

Sun Yat-sen University

Shanghai Jiao Tong University

Peking University

Chinese Academy of Sciences

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Association Between Plasma Trimethylamine N-oxide and Neoatherosclerosis in Patients With Very Late Stent Thrombosis

Canadian Journal of Cardiology (2019)

Yu Ting Tan Jinying Zhou Chen Liu Peng Zhou Zhaoxue Sheng

Trimethylamine N-oxide

10.1016/j.cjca.2019.10.041

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Citations (18)

Association Between Preinfarction Angina and Culprit Lesion Morphology in Patients With ST-Segment Elevation Myocardial Infarction: An Optical Coherence Tomography Study

Frontiers in Cardiovascular Medicine (2022)

Ying Wang Zhaoxue Sheng Jiannan Li Yu Ting Tan Peng Zhou

Background Previous studies reported the cardiac protection effect of preinfarction angina (PIA) in patients with acute myocardial infarction (AMI). We sought to identify culprit-plaque morphology and clinical outcomes associated with PIA in patients with ST-segment elevation myocardial infarction (STEMI) using optical coherence tomography (OCT). Methods and Results A total of 279 patients with STEMI between March 2017 and March 2019 who underwent intravascular OCT of the culprit lesion were prospectively included. Of them, 153 (54.8%) patients were presented with PIA. No differences were observed in clinical and angiographic data between the two groups, except STEMI onset with exertion was significantly less common in the PIA group (24.2 vs. 40.5%, p = 0.004). Patients with PIA exhibited a significantly lower incidence of plaque rupture (40.5 vs. 61.9%, p < 0.001) and lipid-rich plaques (48.4 vs. 69.0%, p = 0.001). The thin-cap fibroatheroma (TCFA) prevalence was lower in the PIA group, presenting a thicker fibrous cap thickness, although statistically significant differences were not observed (20.3 vs. 30.2%, p = 0.070; 129.1 ± 92.0 vs. 111.4 ± 78.1 μm, p = 0.088; respectively). The multivariate logistic regression analysis indicated that PIA was an independent negative predictor of plaque rupture (odds ratio: 0.44, 95% CI: 0.268–0.725, p = 0.001). No significant differences in clinical outcomes were observed besides unplanned revascularization. Conclusion Compared with the non-PIA group, STEMI patients with PIA showed a significantly lower prevalence of plaque rupture and lipid-rich plaques in culprit lesion, implying different mechanisms of STEMI attack in these two groups.

Culprit

Vulnerable plaque

Fibrous cap

10.3389/fcvm.2021.678822

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Citations (2)

Combined with ticagrelor, 50 mg aspirin daily can reduce bleeding events without increasing ischemic risk compared with 75–100 mg aspirin daily in coronary artery disease patients: insights from the TIFU (Ticagrelor in Fuwai Hospital) study

Platelets (2019)

Jiannan Li Zhaoxue Sheng Yu Ting Tan Chen Liu Peng Zhou

Jiannan Li, Zhaoxue Sheng, Yu Tan, Chen Liu, Peng Zhou, Jinying Zhou, Runzhen Chen, Yi Chen, Li Song, Hanjun Zhao & Hongbing Yan*Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, China

10.1080/09537104.2019.1680825

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Citations (8)

Intra-aortic balloon pumping and thrombocytopenia in patients with acute coronary syndrome

Herz (2017)

Zhaoxue Sheng Honglei Zhao Hongbing Yan Shiliang Jiang Yulong Guan

TIMI

10.1007/s00059-017-4599-5

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Association between high-mobility group box 2 and subclinical hypertension-mediated organ damage in young adults

Therapeutic Advances in Chronic Disease (2022)

Jindong Wan Gang Liu Siwei Xia Sen Liu Yi Yang

Hypertension-mediated organ damage (HMOD) is an emerging problem among young adults. The potential role of chronic immune-mediated inflammation in the pathogenesis of HMOD is increasingly being recognized. High-mobility group box 2 (HMGB2) is known for its role in the modulation of innate immunity and exerts signaling functions that affect various inflammatory diseases. However, the association between HMGB2 and HMOD in young adults remains unclear.The aim of this study was to explore the association between HMGB2 and subclinical HMOD in young adults.This is a cross-sectional study.Body composition, carotid ultrasound, carotid-femoral PWV (cf-PWV) measures, echocardiography, serum HMGB2 levels, and serum classic cardiometabolic risk factors were measured in 988 untreated young adults. We estimated the risk related to serum HMGB2 using multivariable-adjusted linear and logistic regression models. Then, we conducted a pathway overrepresentation analysis to examine which key biological pathways may be linked to serum HMGB2 in young adults with HMOD.Among the 988 untreated young adults, we identified four distinct hypertension phenotypes: normotension (40.0%), white-coat hypertension (16.0%), masked hypertension (20.9%), and sustained hypertension (23.1%). High levels of serum HMGB2 were related to increased carotid intima-media thickness (cIMT) and left ventricular mass index (LVMI), higher cf-PWV and blood pressure, and a lower estimated glomerular filtration rate (eGFR). Linear regression analysis showed that serum HMGB2 was positively associated with cf-PWV and negatively associated with eGFR in all patients. Multivariate analysis showed that high levels of serum HMGB2 were associated with high odds of subclinical HMOD (damage in at least one organ). Biological pathway analysis indicated that patients with high serum HMGB2 levels had increased activity of pathways, related to endothelial dysfunction, inflammatory processes, and atherosclerosis.High serum concentrations of HMGB2 are associated with an increased risk of subclinical HMOD in untreated young adults.

Subclinical infection

Pathogenesis

10.1177/20406223221135011

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Citations (4)

AS-164 Association between Local and Systemic Levels of Interleukin-1β and Interleukin-10 in Coronary Artery Disease and Its Clinical Relevance

The American Journal of Cardiology (2011)

Hongbing Yan Wenzheng Li Hanjun Zhao Li Song Bing Zheng

Interleukin 1β

10.1016/j.amjcard.2011.02.115

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[Comparison of six-month follow-up results of primary percutaneous coronary intervention guided by optical coherence tomography or coronary angiography].

PubMed (2020)

Peng Zhou C Liu Yu-Ting Tan Zhaoxue Sheng J N Li

Objective: To compare the 6-month follow-up results of primary percutaneous coronary intervention (PPCI) guided by optical coherence tomography (OCT) or coronary angiography (CAG) alone in a larger ST-segment elevation myocardial infarction (STEMI) cohort. Methods: We enrolled 275 STEMI patients undergoing OCT-guided PPCI from March 2017 through December 2018. Two hundred and seventy-five propensity score matched STEMI patients undergoing CAG-guided PPCI served as control group. The 6-month clinical follow-up results were compared between the two groups. The demographic data, complications, coronary angiography and OCT characteristics were evaluated. Results: OCT evaluation showed that there were 151 patients (54.9%) with plaque prolapse and 113 patients (41.1%) with stent malposition. Proximal and/or distal dissection of stents occurred in 38 patients (13.8%), of which 3 patients (1.1%) had both proximal and distal dissection. Of the 38 patients, 2 patients received rescue stent implantation. Results of clinical follow-up at 6 months showed that there was no significant difference in cardiovascular death, repeat myocardial infarction, target vessel revascularization, stroke and hemorrhage endpoint events between OCT-guided PPCI patients and CAG-guided PPCI patients (P=0.682). Conclusion: Clinical events at 6 months are similar between OCT-guided PPCI and CAG-guided PPCI for STEMI patients.目的：比较光学相干断层成像（OCT）指导和单纯冠状动脉造影（CAG）指导直接冠状动脉介入治疗（PPCI）6个月的随访结果。方法：前瞻性研究。连续入选2017年3月至2018年12月阜外医院因ST段抬高型心肌梗死（STEMI）行OCT指导的PPCI患者275例（OCT指导组）。收集全部入选患者的人口学资料、合并疾病、冠状动脉造影和OCT特征资料。采用倾向性评分从单纯CAG指导的PPCI患者数据库中1∶1回顾性顺序匹配275例患者（CAG指导组），对比两种策略对6个月临床随访结果的影响。结果： OCT指导组中，OCT评估发现斑块脱垂151例（54.9%），支架贴壁不良113例（41.1%），支架近和/或远端夹层38例（13.8%），其中3例（1.1%）同时发生支架近端和远端夹层，38例远端夹层患者中，需行补救性置入支架2例。随访6个月结果显示，OCT指导组与CAG指导组比较，心血管死亡、再次心肌梗死、靶血管再次血运重建、卒中和出血终点事件差异均无统计学意义（P=0.682）。结论：与单纯CAG指导相比，OCT指导的PPCI并不能降低6个月的临床终点事件。.

Clinical endpoint

10.3760/cma.j.cn112148-20190722-00419

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Screening and detecting proteins interacting with the Nterminal of MINT

Di-Si Junyi Daxue xuebao (2003)

Peng Zhou

AIM: To study the mechanism of the repression of MINT, a 3576aa protein in nuclear matrix, and to further clarify the regulation of the pathway of Notch, yeast two hybrid assay was used to screen molecules which can interact with MINT F1(amino acids 1 365). METHODS: The bait vector was constructed by inserting Mint F1 into pGBKT7 to screen the cDNA library of human lymph node. The positive clones were restrictively digested and sequenced for further analysis. RESULTS: Seventy three clones were obtained after 6×10 7 clones were yielded by the four kinds of nutrition limitation and β galactosidase assays. Twelve positive clones were obtained after restriction of positive clones. Sequencing of the clones showed that there were 3 significative molecules: small nuclear ribonucleoprotein polypeptide G (SNRPG), Vav oncogene and microspherule protein 1 (MCRS1). CONCLUSION: Analysing with the 3 molecules obtained from the human cDNA library, we can see that the function of MINT may be complex, it may participate in the splicing of RNA by affecting the spliceosomal small nuclear ribonucleoproteins (snRNPs), or regulate the cellular signal transduction pathway by interacting with some signal transduction factors, such as Vav1 and RBP Jκ. It may also affect the size and shape of the nucleolus through MCRS1.

Two-hybrid screening

snRNP

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Zonal interdependence in the temporomandibular joint cartilage

The FASEB Journal (2023)

Xiaojie Xu Yuejiao Zhang Jing Zhang Dongmei Wang Hongxu Yang

Abstract The temporomandibular joint (TMJ) cartilage is biomechanical sensitive. Cells in TMJ cartilage are zonally arranged, earlier differentiated in the super zone and late differentiated in the deep zone. The purpose was to detect the zonal interdependence in TMJ cartilage under dental biomechanical stimulations. Here, we obtained the Sox9 CreER ; Rosa26 tdTomato and Col10 CreER ; Rosa26 tdTomato mice to label super zone Sox9‐expressing (Sox9 + ) or deep zone Col10‐expressing (Col10 + ) cells by tdTomato (TdT), and Sox9 CreER ; Rosa26 DTA and Col10 CreER ; Rosa26 DTA mice to ablate Sox9 + or Col10 + cells selectively. These mice were subjected to unilateral anterior crossbite (UAC) or bilateral anterior elevation (BAE) dental stimulation, which promoted terminal differentiation or proliferation of TMJ chondrocytes, respectively. In both UAC and BAE models, the Sox9‐TdT + cells performed as proliferation and mature differentiation, showing as expressing Ki67 and Col‐X, respectively; while the Col10‐TdT + cells performed as terminal differentiation, showing as expressing osteocalcin (OCN). In both Sox9 + ‐ and Col10 + ‐cells ablation groups, there were reductions in cell number, cartilage thickness and matrix amount, subchondral bone loss, and condylar deformation. The UAC‐promoted terminal differentiation was enhanced, and the BAE‐promoted cellular proliferation was ruined. Impressively, when Col10 + cells were ablated, the UAC‐promoted DAP3 expression, an anoikis marker, was further increased, while the BAE‐suppressed DAP3 expression was instead greatly increased. These findings demonstrated that the cartilage zones function interdependently. The super zone harbors the cells that undergo differentiation to deep zone cells, the deep zone contains load‐bearing matrix which is structural essential for the cells located inside or superficial.

SOX9

Matrix (chemical analysis)

10.1096/fj.202201662rr

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Citations (3)

Ticagrelor Versus Clopidogrel in Patients with Late or Very Late Stent Thrombosis

Cardiovascular Drugs and Therapy (2020)

Jinying Zhou Yu Ting Tan Chen Liu Peng Zhou Zhaoxue Sheng

Mace

Stroke

10.1007/s10557-020-07021-w

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Citations (3)