Katja Kollewe

Medizinische Hochschule Hannover

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Reinhard Dengler

Medizinische Hochschule Hannover

Susanne Petri

Medizinische Hochschule Hannover

Stefan Vielhaber

Otto-von-Guericke University Magdeburg

Judith Machts

German Center for Neurodegenerative Diseases

Susanne Abdulla

Medizinische Hochschule Hannover

Bahram Mohammadi

University of Adelaide

Lejla Paracka

Medizinische Hochschule Hannover

Dirk Dressler

Medizinische Hochschule Hannover

Hans‐Jochen Heinze

Leibniz Institute for Neurobiology

Amir Samii

International Neuroscience Institute

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Medizinische Hochschule Hannover

142

German Center for Neurodegenerative Diseases

Otto-von-Guericke University Magdeburg

Klinik und Poliklinik für Neurologie

University of Lübeck

University Hospital Schleswig-Holstein

University Hospital Magdeburg

Heidelberg University

Charité - Universitätsmedizin Berlin

Universität Ulm

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Age and education-matched cut-off scores for the revised German/Swiss-German version of ECAS

Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration (2016)

Markus Loose Christian Burkhardt Helena E. A. Aho-Özhan Jürgen Keller Susanne Abdulla

The Edinburgh Cognitive and Behavioural ALS Screen (ECAS) has been developed to assess cognition and behaviour in patients with amyotrophic lateral sclerosis (ALS). Cognitive impairments of ALS-specific and ALS-non-specific functions can be determined using cut-off scores based on performance of healthy subjects. However, detailed analyses show that older healthy subjects perform worse than younger ones, whereas highly-educated individuals perform better than those with lower education levels. As a consequence, this study presents new age and education matched cut-off scores for the revised German/Swiss-German version of the ECAS based on the performance of 86 healthy subjects.

10.3109/21678421.2016.1162814

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Citations (43)

Value of quantitative analysis of routine clinical MRI sequences in ALS

Amyotrophic Lateral Sclerosis (2011)

Xiao‐Qi Ding Katja Kollewe Katrin S. Blum Sonja Körner Sonja Kehbel

Simple morphological assessment of conventional MRI used in routine neurological diagnostic work-up lacks sensitivity and specificity for amyotrophic lateral sclerosis (ALS). Quantitative analysis of routine MRI sequences might, however, be more suitable to reveal ALS-related pathological cerebral alterations. We investigated 10 ALS patients and 10 age- and sex-matched healthy controls by MRI. Brain maps of T2 relaxation time (T2), relative proton density (PD), and apparent diffusion coefficient (ADC) were obtained. Values of these parameters were measured in 22 selected brain regions, and compared among the patients and the controls by using paired t-test with Bonferroni corrected alpha level (= 0.002). In ALS patients, increased PD was found in the pyramidal tract, corpus callosum, and white and grey matter. T2 elongation was found at the genu of corpus callosum, and at the posterior limb of the internal capsule (ICP). ADC values showed a tendency towards an increase in patients, which was only significant at the ICP. PD therefore appeared to be the most sensitive parameter for the detection of degenerative changes not only in the motor system but also in extramotor brain regions.

Corticospinal tract

Pyramidal tracts

T2 relaxation

10.3109/17482968.2011.597402

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Two consecutive pregnancies in early and late stage of amyotrophic lateral sclerosis

Amyotrophic Lateral Sclerosis (2009)

Stayko Sarafov Maryana Doitchinova Zhvka Karagiozova B Slancheva Reinhard Dengler

There are few reports on pregnancies in sporadic and familial amyotrophic lateral sclerosis (ALS). We report on a young woman with sporadic ALS who gave birth twice during the course of her disease. The first pregnancy occurred 13 months after the onset of symptoms, and one month after diagnosis. The pregnancy was uncomplicated and resulted in vaginal delivery of a healthy boy. Fifteen months later, when she was already bed-ridden, she became pregnant again. She received a percutaneous endoscopic gastrostomy in the 21st gestational week and underwent early Caesarean section in the 34th week of gestation. The child was ventilated for 72 h in a neonatological unit. The patient was tracheotomized and ventilated two months later, i.e. 47 months after symptom onset, and died nine months later from gastrointestinal haemorrhage. Her two children have developed without abnormalities to date. This case confirms that pregnancies in early-stage ALS can develop normally and may result in uncomplicated vaginal delivery. Pregnancies in late stages may be critical for mother and child, and early delivery by Caesarean section may become necessary although neonatal outcome can be good.

10.3109/17482960802578365

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Citations (25)

Two consecutive pregnancies in early and late stage of amyotrophic lateral sclerosis

Amyotrophic Lateral Sclerosis (2009)

Stayko Sarafov Maryana Doitchinova Zhvka Karagiozova B Slancheva Reinhard Dengler

10.1080/17482960802578365

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Citations (2)

V14. Complementary use of central and peripheral non-invasive imaging to distinguish between subtypes in amyotrophic lateral sclerosis

Clinical Neurophysiology (2015)

S. Abdulla Karen Lowe Stefanie Schreiber Jörn Kaufmann Grażyna Dębska‐Vielhaber

Upper motor neuron

Corticospinal tract

Cerebral peduncle

10.1016/j.clinph.2015.04.092

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Somatosensory evoked potentials recorded from DBS electrodes: the origin of subcortical N18

Journal of Neural Transmission (2024)

Arif Abdulbaki Johannes C. Wöhrle Christian Blahak Ralf Weigel Katja Kollewe

Subthalamic Nucleus

Zona incerta

Somatosensory evoked potential

10.1007/s00702-024-02752-8

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151. Botulinum neurotoxin therapy for hyperhidrosis: reduction of injection site pain by nitrous oxide/oxygen mixtures

Toxicon (2014)

Lejla Paracka Katja Kollewe Dirk Dressler

Nitrous oxide

Botulinum neurotoxin

10.1016/j.toxicon.2014.11.154

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Citations (1)

Peripheral nerve ultrasound in amyotrophic lateral sclerosis phenotypes

Muscle & Nerve (2014)

Stefanie Schreiber Susanne Abdulla Grażyna Dębska‐Vielhaber Judith Machts Verena Dannhardt‐Stieger

In this study we sought to determine the cross-sectional area (CSA) of peripheral nerves in patients with distinct subtypes of amyotrophic lateral sclerosis (ALS).Ulnar and median nerve ultrasound was performed in 78 ALS patients [classic, n = 21; upper motor neuron dominant (UMND), n = 14; lower motor neuron dominant (LMND), n = 20; bulbar, n = 15; primary lateral sclerosis (PLS), n = 8] and 18 matched healthy controls.Compared with controls, ALS patients had significant, distally pronounced reductions of ulnar CSA (forearm/wrist level) across all disease groups, except for PLS. Median nerve CSA (forearm/wrist level) did not differ between controls and ALS.Ulnar nerve ultrasound in ALS subgroups revealed significant differences in distal CSA values, which suggests it has value as a marker of LMN involvement. Its potential was particularly evident in the UMND and PLS groups, which can be hard to separate clinically, yet their accurate separation has major prognostic implications.

Lower motor neuron

Upper motor neuron

10.1002/mus.24431

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Citations (63)

Management of Amyotrophic Lateral Sclerosis

Peter M. Andersen Sharon Abrahams Gian Domenico Borasio Mamede de Carvalho Adriano Chiò

This chapter contains sections titled: Introduction Search strategy Results References

10.1002/9781444328394.ch17

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Citations (6)

Quantifying disease progression in amyotrophic lateral sclerosis using peripheral nerve sonography

Muscle & Nerve (2016)

Stefanie Schreiber Verena Dannhardt‐Stieger Dorothea Henkel Grażyna Dębska‐Vielhaber Judith Machts

ABSTRACT Introduction: In this study we investigated whether peripheral nerve sonography could be used as a biomarker to monitor disease progression in amyotrophic lateral sclerosis (ALS). Methods: In 37 patients, ulnar and median nerve cross‐sectional area (CSA) was determined in at least 2 ultrasound sessions; mean follow‐up was 14.5 months. Linear mixed‐effects models were conducted to analyze time effects on CSA. Results: Ulnar nerve CSA declined significantly at a monthly rate of –0.04 mm 2 (forearm) and –0.05 mm 2 (wrist); the decrease was more pronounced when baseline CSA was greater. To detect a 50% treatment effect on ulnar nerve CSA, 332 patients would need to be entered in a hypothetical randomized, controlled clinical trial. Time had no significant impact on median nerve CSA. Conclusions: Distal ulnar nerve ultrasound may be a useful biomarker to monitor disease progression in ALS, especially as hypothetical treatment effects on CSA seem to be detectable in manageable cohort sizes. Muscle Nerve 54 : 391–397, 2016

10.1002/mus.25066

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Citations (43)