<p>The supplementary data include one table and 5 figures. Table S1 presents cabazitaxel cytotoxic activity in the human breast cancer cell line MCF-7, uterine sarcoma cell line MES-SA, and ovarian cancer cell lines ES-2, MES-OV, and OVCAR-3. Figure S1 presents the molecular structure of cabazitaxel and cytotoxicity curves for three taxanes in MCF-7 cells. Figure S2 shows an immunoblot of drug transporter proteins in parental and drug resistant variants of MCF-7. Figure S3 shown rhodamine123 and BODIPY-paclitaxel accumulation by flow cytometry in parental and resistant variants. Figure S4 shows polymerized versus soluble tubulin in parental vs resistant variants. Figure S5 shows expression of apoptotic regulators.</p>
<p>The supplementary data include one table and 5 figures. Table S1 presents cabazitaxel cytotoxic activity in the human breast cancer cell line MCF-7, uterine sarcoma cell line MES-SA, and ovarian cancer cell lines ES-2, MES-OV, and OVCAR-3. Figure S1 presents the molecular structure of cabazitaxel and cytotoxicity curves for three taxanes in MCF-7 cells. Figure S2 shows an immunoblot of drug transporter proteins in parental and drug resistant variants of MCF-7. Figure S3 shown rhodamine123 and BODIPY-paclitaxel accumulation by flow cytometry in parental and resistant variants. Figure S4 shows polymerized versus soluble tubulin in parental vs resistant variants. Figure S5 shows expression of apoptotic regulators.</p>
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