Prakash Katakam

Hindu College of Pharmacy

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Shanta Kumari Adiki

Kanya Maha Vidyalaya

Babu Rao Chandu

Al Zawiya University

Nagiat T. Hwisa

University of Illinois Urbana-Champaign

Fathi H. Assaleh

Libyan Academy

Analava Mitra

Indian Institute of Technology Kharagpur

Koushik Bhandari

Indian Institute of Technology Kharagpur

Baishakhi De

Indian Institute of Technology Kharagpur

Baishakhi Dey

Bangladesh Agricultural University

Rajeev K. Singla

Sichuan University

Rohit Gundamaraju

University of Tasmania

Cooperative Institutions

Al Zawiya University

Indian Institute of Technology Kharagpur

Guntur Medical College

Acharya Nagarjuna University

Prince Sattam Bin Abdulaziz University

Lovely Professional University

Netaji Subhas University of Technology

Jawaharlal Nehru Technological University, Hyderabad

University of Malaya

Creative Research Enterprises (United States)

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3D-Printed Pharmaceuticals

CRC Press eBooks (2024)

Raja Rajeswari Kamisetti Ajmeer Ramkishan Prakash Katakam Subhas Sahoo

3d printed

10.1201/9781003439509-19

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An Experimental Design Approach for Impurity Profiling of Valacyclovir-Related Products by RP-HPLC

Scientia Pharmaceutica (2014)

Prakash Katakam

Impurity profiling has become an important phase of pharmaceutical research where both spectroscopic and chromatographic methods find applications. The analytical methodology needs to be very sensitive, specific, and precise which will separate and determine the impurity of interest at the 0.1% level. Current research reports a validated RP-HPLC method to detect and separate valacyclovir-related impurities (Imp-E and Imp-G) using the Box-Behnken design approach of response surface methodology. A gradient mobile phase (buffer: acetonitrile as mobile phase A and acetonitrile: methanol as mobile phase B) was used. Linearity was found in the concentration range of 50–150 μg/mL. The mean recovery of impurities was 99.9% and 103.2%, respectively. The %RSD for the peak areas of Imp-E and Imp-G were 0.9 and 0.1, respectively. No blank interferences at the retention times of the impurities suggest the specificity of the method. The LOD values were 0.0024 μg/mL for Imp-E and 0.04 μg/mL for Imp-G and the LOQ values were obtained as 0.0082 μg/mL and 0.136 μg/mL, respectively, for the impurities. The S/N ratios in both cases were within the specification limits. Proper peak shapes and satisfactory resolution with good retention times suggested the suitability of the method for impurity profiling of valacyclovir-related drug substances.

Box–Behnken design

10.3797/scipharm.1403-20

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Exploring the Potential of 3D Printing in Personalized Medicine

CRC Press eBooks (2025)

Kiranmai Mandava Prakash Katakam Sneha Thakur B Suhasini Purre Reecha

A cutting-edge instrument that has the potential to revolutionize several facets of customized medicine is 3D printing technology. The most recent cutting-edge uses of additive manufacturing in personalized healthcare are examined in this paper, including anatomical models, medical devices, drug delivery systems, and tissue engineering. The capacity to create medications and medical equipment customized for each patient has created new opportunities for individualized treatment plans that improve patient outcomes while cutting expenses. Accurate anatomical models can also be created with 3D printing for planning surgeries and medical teaching. To fully achieve the potential of 3D printing in customized medicine, however, obstacles like material constraints, regulatory concerns, and scalability issues must be resolved.

Personalized Medicine

10.1201/9781003618140-114

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Development and Characterization of Calcium-Alginate Beads of Apigenin: In Vitro Antitumor, Antibacterial, and Antioxidant Activities

Marine Drugs (2021)

Mohammed F. Aldawsari Mohammed Muqtader Ahmed Farhat Fatima Md. Khalid Anwer Prakash Katakam

The objective of this work was to develop sustained-release Ca-alginate beads of apigenin using sodium alginate, a natural polysaccharide. Six batches were prepared by applying the ionotropic gelation technique, wherein calcium chloride was used as a crosslinking agent. The beads were evaluated for particle size, drug loading, percentage yield, and in vitro drug release. Particle size was found to decrease, and drug entrapment efficiency was enhanced with an increase in the polymer concentration. The dissolution study showed sustained drug release from the apigenin-loaded alginate beads with an increase in the polymer proportion. Based on the dissolution profiles, BD6 formulation was optimized and characterized for FTIR, DSC, XRD, and SEM, results of which indicated successful development of apigenin-loaded Ca alginate beads. MTT assay demonstrated a potential anticancer effect against the breast cancer MCF-7 cell lines. The antimicrobial activity exhibited effective inhibition in the bacterial and fungal growth rate. The DPPH measurement revealed that the formulation had substantial antioxidant activity, with EC50 value slightly lowered compared to pure apigenin. A stability study demonstrated that the BD6 was stable with similar (f2) drug release profiles in harsh condition. In conclusion, alginate-based beads could be used for sustaining the drug release of poorly water-soluble apigenin while also improving in vitro antitumor, antimicrobial, and antioxidant activity.

Calcium alginate

10.3390/md19080467

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Formulation and in-vitro evaluation of moxifloxacin loaded crosslinked chitosan films for the treatment of periodontitis

Journal of Pharmacy Research (2013)

Durga Praveena Chinta Prakash Katakam Varanasi Satya Narayana Murthy Maria J. Newton

Biopharmaceutics

Natural Product Research

10.1016/j.jopr.2013.06.019

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Phytosomes: A Novel Phytoconstituent Delivery Approach to Improve the Efficacy of Obesity Treatment

Current Nutrition & Food Science (2022)

Shanta Kumari Adiki Shanmugasundaram Sangeetha Srikala Kamireddy Prakash Katakam Iswarya Obilineni

Objectives: This review provides a detailed review of the treatment of obesity with natural products that are formulated as phytosomes. When novel drug delivery technology is used instead of traditional drug delivery in herbal medicine, side effects are reduced while safety and efficacy are improved.This article provides information about obesity along with its treatment and with special emphasis on phytosomes, their preparation and evaluation along with their application in obesity. Methods: A comprehensive search of electronic databases such as Medline, Embase, Cochrane Library, Google, and Google Patents was carried out. Results: This review explains the details of research done on phytosomes with special reference to anti-obesity drugs. Still, there is a need to formulate anti-obesity herbal drugs as phytosomes to get better bioavailability, and fewer side effects. This phytosomal drug delivery approach may resolve the problems associated with conventional drug delivery. Conclusion: Integrating herbal medicine with novel drug delivery systems such as phytosomes to combat obesity has a significant scope and importance.

Scope (computer science)

10.2174/1573401318666220901125859

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A Comparative Evaluation of Drug Release and Permeability of Ethylcellulose, Cellulose Acetate and Eudragit RS100 Microspheres

International Journal of Scientific Research in Knowledge (2014)

Prakash Katakam Saousen R. Diaf Baishakhi Dey Shanta Kumari Adiki Babu Rao Chandu

Present study aims at comparative evaluation of drug release and permeability of diclofenac sodium loaded ethylcellulose (EC), cellulose acetate (CA) and eudragit (EU) microspheres. Microspheres of EC, CA and EU containing diclofenac sodium were prepared by an emulsification-solvent evaporation (oil-in-oil, o/o) method and were investigated for a comparative evaluation of various parameters. The microspheres were found discrete, free flowing, multinucleate, monolithic and spherical. About 5560% of all microspheres prepared were in the size range of -20+30 (715 m) mesh size. The encapsulation efficiency was in the range of 97.1106.4% with various polymers. The wall thickness of microspheres was in the range of 13.69-74.97m which depended on polymer employed and was directly proportional to polymer concentration. Diclofenac release from the microspheres was slow over longer periods of time and depended on the polymer used and coat:core ratio. Release was diffusion controlled and followed first order kinetics. Good linear relationships were observed between percent coat, wall thickness and release rate constant with all the three polymers. The slopes of percent coat vs release rate (k1) plots were found to be 0.4117, 0.2351 and 0.9762; and those of wall thickness (h) vs drug release rate (k1) plots were found 0.2549, 0.1863 and 0.7850 respectively for EC, CA and EU microspheres. The lower the slope the better is the controlling effect. Cellulose acetate exhibited better release-controlling effect than that of ethylcellulose and eudragit. The increasing order of diclofenac release rate and permeability observed with various microspheres was, cellulose acetate < ethylcellulose < eudragit RS100. The possible permeability of drug from the prepared porous micrsopheres could be due to osmotic pressure generated by diclofenac.

Cellulose acetate

10.12983/ijsrk-2014-p0075-0082

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3D printing materials for sensors and their commercial availability

IOP Publishing eBooks (2024)

Prakash Katakam Madhavi Lakshmi Ratna Bhavaraju Shanta Kumari Adiki

10.1088/978-0-7503-5351-9ch4

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Recent Advancements of Additive Manufacturing for Patient-Specific Drug Delivery

CRC Press eBooks (2022)

Prakash Katakam Shanta Kumari Adiki Soumya Ranjan Satapathy

Recently, patient-specific medication has continued to trend the most, reflecting all aspects of therapeutics, including drug delivery. The most successful formulations for drug delivery are solid orals that can be easily swallowed and are more patient-friendly. Fast- melting, dissolving, and disintegrating tablets or gel forming formulations are more acceptable to these special populations, such as pediatrics and geriatrics. Additive manufacturing, or three-dimensional (3D) printing has revolutionizing every manufacturing industry. For formulation technology, 3D printing has brought the versatility needed to rapidly develop novel dosage forms at a low cost. Now it is quite possible to formulate complex forms containing multiple active ingredients in single-dosage form. Furthermore, using 3D printing we can customize the drug-release profiles as per the individualized needs of the patients. The production of patient-specific dosage forms is much flexible and can be done at the pharmacy or even at a patient's home in the future.

Three dimensional printing

10.1201/9781003217961-1

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FORMULATION AND IN VITRO - IN VIVO EVALUATION OF TETANUS TOXOID-MANNITOL DRY POWDER INHALATION FOR PULMONARY DELIVERY

Ankara Universitesi Eczacilik Fakultesi Dergisi (2023)

Mary Manoranjani ADDANKİ Prakash Katakam Shanta Kumari Adiki Jessi Dason VARDHANAPU Nagabhushana Vinay Kumar

Objective: A dry powder inhalation of tetanus toxoid and mannitol was prepared and evaluated for stability and its immunogenicity in comparison to the conventional TT vaccine. Material and Method: TT and mannitol dry powder inhalation was prepared and evaluated for particle size analysis, FTIR, flow properties, encapsulation efficiency, flocculation, and in vitro drug vaccine release studies. Immunological studies of the formulation were performed on BALB/c mice. Result and Discussion: The powder blend of tetanus toxoid and mannitol remained stable under the process conditions and after storage. The result was confirmed through a flocculation test. No interactions were reported according to FTIR analysis. The homogenization process yielded a powder with a geometrical particle size diameter of 1312 ± 1310.9 nm which was found suitable for pulmonary administration. The zeta potential and PDI were found to be -22.6 ± 0.16 mV and 0.499 ± 0.015, respectively. The diffusion studies indicated immediate release of the TT with 82.4 ± 6.7% of drug released within 2 h following the diffusion mechanism and zero order kinetics. Additionally, the flow properties of the dry powder inhalation were reported to have good flow properties. More importantly, the immunological studies inferred the induction of high systemic and mucosal immunity over conventional vaccines.

Toxoid

Zeta potential

10.33483/jfpau.1142898

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