Abstract An efficient eco-friendly synthesis of 4-aryl tetrazolo[1,5-a][1,8]naphthyridine derivatives have been successfully prepared through microwave method in short reaction time. The microwave method has unique advantages, short reaction time, easy workup procedure, and simple purification of the products. Synthesized the entire molecule evaluated for their antimicrobial activity among them compounds 6g and 6a demonstrated highest anti-microbial activity. Moreover, in silico molecular modeling evaluation has done by considering docking scores, hydrogen bond interactions, affinity, and the short distance between ligand and receptor. All the molecules good docking results have shown that binding interactions with the target protein and obtained results were well complemented to the antimicrobial activity.
New York City’s Department of Transportation is in the process of evaluating and, if necessary, rehabilitating its many important bridges to meet seismic guidelines. In a comprehensive two-part evaluation of the Brooklyn Bridge that used the latest modeling techniques, engineers determined that the bridge’s foundations have the ability to withstand a 2,500-year event without any sliding or separation at their bases, obviating the need for retrofits that might alter the architectural form of the renowned crossing.
A comprehensive seismic investigation of the Brooklyn Bridge was completed to assess its potential retrofit needs. The Brooklyn Bridge, built in 1883, has become a national treasure and architectural and engineering marvel. To ensure that the seismic retrofit needs of the bridge were based on a rational framework, avoiding overconservatism that would potentially lead to unnecessary retrofit and impacting negatively on the architecture of the bridge, advanced engineering investigations of the condition of the bridge and its seismic response were made. Specifically, the seismic investigation of the main bridge was performed following two approaches, referred to as the global and local analyses. In the global analysis, the entire main bridge with its foundation caissons was modeled, and the effects of soil-foundation interaction were incorporate through the use of foundation impedances. In the local analysis, each bridge tower with its caisson and the surrounding soils was investigated with a model using solid finite difference and slip and gap interface elements. The local analyses of the towers were performed to confirm quality of the motions and foundation impedances used in the global analysis, and to ensure that the conclusions regarding the potential need for foundation retrofitting was realistic and essential. This paper presents the details of the two seismic evaluation approaches, and compares the bridge foundation responses from both analyses. It also demonstrates the benefits of local analysis in the seismic evaluation of long-span bridges.
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