Leire Ruiz‐Rubio

Basque Center for Materials, Applications and Nanostructures

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José Luis Vilas‐Vilela

University of the Basque Country

104

Leyre Pérez‐Álvarez

University of the Basque Country

S. Lanceros‐Méndez

Ikerbasque

Isabel Moreno

University of the Basque Country

Antonio Veloso

Institute of Macromolecular Chemistry

José Manuel Laza

University of the Basque Country

José Luis Vilas Vilela

University of the Basque Country

L. M. León

Universidad Nacional de Colombia

Julia Sanchez‐Bodón

University of the Basque Country

Mikel Azkune

University of the Basque Country

Cooperative Institutions

University of the Basque Country

142

Basque Center for Materials, Applications and Nanostructures

Ministerio de Ciencia y Tecnología

Euskadiko Parke Teknologikoa

Consejo Superior de Investigaciones Científicas

Tshwane University of Technology

Ikerbasque

Centre National de la Recherche Scientifique

Universidad Nacional Autónoma de México

CIC energiGUNE

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Hydrolysis of poly(l‐lactide)/ZnO nanocomposites with antimicrobial activity

Journal of Applied Polymer Science (2019)

Leyre Pérez‐Álvarez Erlantz Lizundia Leire Ruiz‐Rubio Vanessa Benito Isabel Moreno

ABSTRACT This work investigates the effect of the incorporation of zinc oxide (ZnO) nanoparticles within a poly( l ‐lactic acid) (PLLA) matrix as an approach to speed up the hydrolysis of PLLA film surfaces. Hydrolysis was done by immersing nanocomposite films having 1 wt % of ZnO in 0.25 M sodium hydroxide at 58 °C. This concentration has been selected as it provides the maximum changes of physicochemical properties of hosting PLLA matrix. The evolution of the thermal properties, ultraviolet–visible transparency, wettability, and morphology were monitored at different time points. The amount of carboxylic groups onto PLLA/ZnO surfaces was quantified according to Toludine Blue‐O assay. Hydrolysis was mainly limited to film surfaces, which were grafted by carboxylic groups as a result of the random scission of PLLA ester linkages. The presence of such functional groups decreases the inherent surface hydrophobicity of PLLA at short hydrolysis times. On the contrary, long hydrolyses increase the hydrophobicity as a result of surface nanostructuring induced by the degradation of PLLA to water‐soluble oligomers. Overall, ZnO nanoparticles enable shorter surface modification times and provide a quick approach for the modification on the polarity of polylactide surfaces. The potential of hydrolyzed films as antimicrobial materials was explored using Gram‐negative Escherichia coli as a model. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019 , 136 , 47786.

Sodium hydroxide

10.1002/app.47786

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Citations (7)

Exploring anti-corrosion properties and rheological behaviour of tannic acid and epoxidized soybean oil-based fully bio-based epoxy thermoset resins

Progress in Organic Coatings (2024)

Rubén Teijido Cristina Monteserín Miren Blanco José Luis Larrañaga Odriozola Miren Itxaso Maguregui Olabarria

Thermosetting polymer

Tannic acid

Epoxidized soybean oil

Soybean oil

10.1016/j.porgcoat.2024.108719

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Citations (1)

ENHANCING PHYSICAL CHEMISTRY KNOWLEDGE AND SOFT SKILLS BY SHORT IN-CLASS ACTIVITIES

INTED proceedings (2023)

Julia Sanchez‐Bodón Cesar Martín A. Benito Iratxe Rojo Bartolomé Leyre Pérez‐Álvarez

J. Sanchez-Bodón C. MartínA. BenitoI. Rojo BartoloméL. Pérez-ÁlvarezA.C. LopesJ.L. Vilas VilelaL. Ruiz-Rubio

Soft Skills

10.21125/inted.2023.2193

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Shape‐memory Polymers for Tissue Engineering Applications

Fangyuan Zheng Alejandra García‐García Isabel Moreno Leire Ruiz‐Rubio Leyre Pérez‐Álvarez

Growing interest on tissue engineering has driven the fast advancement of shape-memory polymers. These materials are able to recover a programmed shape when an external stimulus is applied. This unique functionality has been used to promote tissue defect filling and stimulate cell differentiation and new tissue generation. In this review, we describe the structural specifications that explain the shape recovery in the diverse range of shape-memory polymers, as well as the critical requirements that must been considered in their design to their successful integration and in vivo performance. Moreover, this chapter reviews recent investigations related to tissue engineering applications of shape-memory homopolymers/copolymers, composites, and hydrogels. We reviewed the physicochemical properties of SMPs with a huge variety of structures and trigger stimuli, and their contributions to the tissue regeneration and formation in cellular and in vivo experiments devoted to the repair of different tissue types. New perspectives in the field that allow the effective translation of these materials to the clinic are also highlighted.

Shape-memory polymer

10.1002/9783527838882.ch3

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Multifunctional antibacterial chitosan-based hydrogel coatings on Ti6Al4V biomaterial for biomedical implant applications

International Journal of Biological Macromolecules (2023)

Jon Andrade del Olmo Leyre Pérez‐Álvarez Virginia Sáez‐Martínez Sandra Benito Cid Leire Ruiz‐Rubio

Biocompatibility

Genipin

Biomaterial

10.1016/j.ijbiomac.2023.123328

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Citations (31)

Characterization and Optimization of the Alkaline Hydrolysis of Polyacrylonitrile Membranes

Polymers (2019)

Leyre Pérez‐Álvarez Leire Ruiz‐Rubio Isabel Moreno José Luis Vilas‐Vilela

There is currently an increasing interest in the development of polyacrylonitrile (PAN)-based membranes with new and enhanced properties which are of special importance in the processes of pervaporation, purification, and water treatment. Thus, the optimization of the functionalization of PAN membranes and its effect on their morphology, hydrophilicity, and mechanical properties plays an essential role in a wide range of applications. In this paper, the alkaline hydrolysis of asymmetric PAN membranes was investigated in order to get carboxyl-enriched surfaces that are of a great interest for more demanding subsequent modifications. The process was monitored using –C=NH intermediate bonds, which could be observed during the hydrolysis reaction by X-Ray photoelectron spectroscopy (XPS) and Fourier-transform infrared spectroscopy (FTIR) before the formation of carboxyl and amide groups. The amount of introduced carboxylic acid groups could be determined by thermogravimetric analysis (TGA) and by the interaction with toluidine blue O (TBO) dye. Hydrolysis was revealed as a simple way to modulate hydrophilicity (decreasing contact angle from 60 to 0° for reaction times from 0–3 h) and the mechanical properties of PAN membranes.

Polyacrylonitrile

Characterization

Alkaline hydrolysis

10.3390/polym11111843

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Citations (58)

Chitosan-Based Nanogels for Biomedical Applications

Leyre Pérez‐Álvarez Leire Ruiz‐Rubio José Luis Vilas‐Vilela

Regarding biomedical applications, chitosan has emerged as an interesting biopolymer in tissue engineering because it can be tuned to suit the biocompatibility, functional and mechanical stability, as well as the increasing requirements that this area demands. Thermoresponsive chitosan-based nanogels were also prepared by complexation and crosslinking of carboxymethyl chitosan with poly-vinyl alcohol (PVA) in order to obtain antibacterial nanogels in the absence of any surfactant. For this, thermosensitive PVA chains could collapse forming by precipitation stable nanospheres above their lower critical solution temperature in aqueous media. Nanogels were formed by posterior interaction of PVA nanospheres with chitosan and covalent crosslinking with N,N-methylenebis(acrylamide), leading to doubly responsive nanogels. Nanoparticles of chitosan have been synthesized by diverse methods and employing different crosslinkers. All methods are based on the restriction of the particle size during crosslinking, which is basically controlled by carrying out it, or in an heterogeneous reaction, such as suspension, emulsion/nanoemulsion/microemulsion, dispersion or precipitation, or based on self-assembly process.

Nanogel

10.1201/9781003045113-8

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Citations (2)

Contributors

Elsevier eBooks (2021)

R. Alves M.I. Arriortua J.M. Barandiarán A. V. Chernenko Daoyong Cong

10.1016/b978-0-12-818501-8.01002-7

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Polimero biobateragarrien garapena biomedikuntzan erabiltzeko

Julian Sánchez Bodón Antonio Veloso Leire Ruiz‐Rubio Leyre Pérez‐Álvarez José Manuel Laza Terroba

10.26876/ikergazte.iv.05.09

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A COMMODITY MATERIAL AS A MAIN DRIVING FORCE: A PROJECT BASED LEARNING IN POLYMER CHEMISTRY

EDULEARN proceedings (2023)

Julia Sanchez‐Bodón Isabel Moreno José Luis Vilas‐Vilela Leire Ruiz‐Rubio

Appears in: EDULEARN23 Proceedings Publication year: 2023Pages: 8154-8157ISBN: 978-84-09-52151-7ISSN: 2340-1117doi: 10.21125/edulearn.2023.2118Conference name: 15th International Conference on Education and New Learning TechnologiesDates: 3-5 July, 2023Location: Palma, Spain

10.21125/edulearn.2023.2118

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