Peter Ehlers

University of Rostock

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Peter Langer

University of Rostock

147

Alexander Villinger

University of Rostock

103

Stefan Lochbrunner

University of Rostock

Anke Spannenberg

Leibniz Institute for Catalysis

P. Langer

University Hospital Cologne

Tuan Thanh Dang

VNU University of Science

Jamshed Iqbal

COMSATS University Islamabad

Silvio Parpart

University of Rostock

Sebastian Reimann

North Dakota State University

Ashot S. Saghyan

Yerevan State University

Cooperative Institutions

University of Rostock

126

Leibniz Institute for Catalysis

Technical University of Munich

California Institute of Technology

University of Turku

Bielefeld University

University of Kashan

Gilead Sciences (Canada)

VNU University of Science

COMSATS University Islamabad

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

Synthesis of 5- and 6-Azaindoles by Sequential Site-Selective Palladium-Catalyzed C–C and C–N Coupling Reactions

Synlett (2020)

Tuan Thanh Dang Peter Langer Nguyễn Thị Son Tuan Anh Nguyen Tien Marian Blanco Ponce

Two-step sequential procedures for the Pd-catalyzed synthesis of 5- and 6-azaindoles are reported. The reactions proceed in very good yields. 6-Azaindoles are formed through site-selective Pd-catalyzed Sonogashira reaction of 3,4-dibromopyridine with alkynes, followed by a Pd-catalyzed tandem C–N coupling and cyclization with amines. On the other hand, 5-azaindoles are obtained by a site-selective Pd-catalyzed C–N coupling reaction of 3,4-dibromopyridine with amines, followed by C–C coupling and cyclization with alkynes.

Sonogashira coupling

Tandem

Coupling reaction

Alkyne

10.1055/s-0040-1707853

Cite

Citations (8)

Palladium-catalyzed synthesis and nucleotide pyrophosphatase inhibition of benzo[4,5]furo[3,2-b]indoles

Beilstein Journal of Organic Chemistry (2019)

Hoang Huy Saif Ullah Alexander Villinger Joanna Lecka Jean Sévigny

A two-step palladium-catalyzed procedure based on Suzuki-Miyaura cross coupling, followed by a double Buchwald-Hartwig reaction, allows for the synthesis of pharmaceutically relevant benzo[4,5]furo[3,2-b]indoles in moderate to very good yield. The synthesized compounds have been analyzed with regard to their inhibitory activity (IC50) of nucleotide pyrophosphatases h-NPP1 and h-NPP3. The activity lies in the nanomolar range. The results were rationalized based on docking studies.

Pyrophosphatases

IC50

10.3762/bjoc.15.276

Cite

Citations (5)

CCDC 2303232: Experimental Crystal Structure Determination

The Cambridge Structural Database (2023)

Jonas Polkaehn Peter Ehlers Alexander Villinger Peter Langer

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

10.5517/ccdc.csd.cc2h9ptb

Cite

Citations (0)

CCDC 2218363: Experimental Crystal Structure Determination

The Cambridge Structural Database (2023)

Erich Ammon Aleksandra Khomutetckaia Alexander Villinger Peter Ehlers P. Langer

10.5517/ccdc.csd.cc2dgd3d

Cite

Citations (0)

Dibenzoacridines: synthesis by alkyne–carbonyl-metathesis and properties

Organic & Biomolecular Chemistry (2023)

Erich Ammon Paul Heine Miguel Andre Argüello Cordero Stefan Lochbrunner Alexander Villinger

Dibenzo[a,j]acridines and regioisomeric dibenzo[c,h]acridines were synthesized from a common starting material, 2,3,5,6-tetrachloropyridine, by combination of site-selective cross-coupling reaction followed by ring-closing alkyne-carbonyl metathesis using simple Brønsted acids. The two regioisomeric series were accessed by change of the order of Sonogashira and Suzuki-Miyaura reactions. The optical properties of the products were studied by steady-state absorption spectroscopy and time-resolved emission measurements. The electronic properties of the products were further elucidated by DFT calculations.

Sonogashira coupling

Alkyne

10.1039/d3ob00407d

Cite

Citations (1)

One-Pot Palladium-Catalyzed Synthesis of Benzo[b]carbazolediones

Synlett (2015)

Peter Langer Hoàng Long Đỗ Tran Quang Hung Lars Ohlendorf Thang Ngoc Ngo

A palladium-catalyzed one-pot reaction for the synthesis of benzo[b]carbazolediones is described which proceeds by amination of 2,3-dibromonaphthoquinone, Suzuki cross-coupling with (2-bromophenyl)boronic acid, and subsequent intramolecular C–N Buchwald–Hartwig cyclization with amines.

Suzuki reaction

Boronic acid

One-pot synthesis

10.1055/s-0035-1560212

Cite

Citations (10)

Synthesis of furo[3,2-b:4,5-b′]diindoles and their optical and electrochemical properties

Organic & Biomolecular Chemistry (2018)

Huy Do Hoang Julia Janke Aneta Amirjanyan Tariel V. Ghochikyan Anika Flader

An efficient two-step palladium catalyzed synthesis of furo[3,2-b:4,5-b′]diindoles, a hitherto unknown symmetrical heterocyclic core structure, was developed.

10.1039/c8ob01737a

Cite

Citations (7)

CCDC 2014906: Experimental Crystal Structure Determination

The Cambridge Structural Database (2020)

Ricardo Molenda Sebastian Boldt Alexander Villinger Peter Ehlers P. Langer

10.5517/ccdc.csd.cc25mnzg

Cite

Citations (0)

CCDC 2090402: Experimental Crystal Structure Determination

The Cambridge Structural Database (2022)

Maryam Sobhani Alexander Villinger Peter Ehlers Peter Langer