Enrico Bronte

Ospedale Vincenzo Cervello

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Antonio Russo

University of Palermo

Giuseppina Novo

University of Palermo

Viviana Bazan

University of Palermo

Giuseppe Bronte

University of Ferrara

Salvatore Novo

University of Palermo

F. Bronte

University of Palermo

Angela Listì

University of Turin

Giuseppe Badalamenti

University of Palermo

Lorena Incorvaia

University of Palermo

Nadia Barraco

University of Palermo

Cooperative Institutions

Istituti di Ricovero e Cura a Carattere Scientifico

245

University of Palermo

108

Azienda Ospedaliera Universitaria Policlinico "Paolo Giaccone" di Palermo

University of Naples Federico II

University of Turin

Sapienza University of Rome

Fondazione IRCCS Istituto Nazionale dei Tumori

University of Padua

University of Palermo

Centro Cardiologico Monzino

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

The effects of LIPUS on ctDNA release in the medium of NSCLC cell lines

Annals of Oncology (2017)

Alessandro Perez Anna Barbara Di Stefano Marta Castiglia Marisa Sorrentino Domenica Matranga

Sonoporation

Sonication

Viability assay

10.1093/annonc/mdx426.025

Cite

Citations (0)

P858 Cardiovascular toxicity induced by immunotherapy and tyrosine kinase inhibitors

European Heart Journal - Cardiovascular Imaging (2020)

D Calcullo Daniela Di Lisi P Iacopelli Cinzia Nugara Enrico Bronte

Abstract Background in the recent years, survival of cancer patients increased enormously through the use of new anticancer drugs such as molecular target drugs (tyrosine kinase inhibitors- TKIs, immunotherapy). Immunotherapy includes anti-BRAF and anti-MEK drugs (although evidences are scarce, these drugs seem to be capable of causing cardiovascular toxicity too); TKIs includes inhibitors of VEGF, VEGFR and other kinases. Purpose to assess cardiovascular toxic effects of TKIs and immunotherapy, to identify early signs of cardiac and vascular toxicity using speckle tracking echocardiography and arterial stiffness measurement. Methods a prospective study was carried out evaluating 45 patients treated with immunotherapy or TKIs. Population was divided into 2 groups: Group A (17 patients with melanoma treated with anti- BRAF and anti-MEK) and Group B (28 patients with solid cancer treated with TKIs-anti VEGF). Cardiological evaluation including electrocardiogram, conventional echocardiogram with tissue Doppler imaging (TDI) and left ventricular global longitudinal strain (GLS) measurement and carotid ultrasound scan was carried out before starting therapy and at a follow-up time of 6 and 12 months. Cardiovascular events such as heart failure, arterial hypertension, arrhythmias, Qtc interval prolongation, stroke, arterial and venous thrombosis were assessed during follow-up. Results mean follow-up was 7 months for anti-BRAF and 13 months for TKI. Neither cardiovascular adverse events nor significant reductions in LVEF or other echocardiographic parameters during follow-up were observed in Group A: we did not observe significant changes in GLS (-18,4 [RI -19,9 a -15,8] vs. -18,3 [RI -18,9 a -16,1] or in vascular parameters (PWV 7,3 ± 1,4 vs. 6,7 ± 1,5, β mean wave 8,5 [RI 6,3-12] vs. 7,4 [RI 4,9-9,4]; α mean wave 6,8 [RI 3,1-6,2] vs. 9,6 [RI 2,4-4,6]). As regards Group B, new onset of arterial hypertension in 35% of population but no significant changes in LVEF or other echocardiographic parameters including GLS ( -18,6 ± 2,3 vs. -18,3 ± 3,3) were observed. Significant changes were furthermore found in vascular parameters with increased arterial stiffness during follow-up (PWV 7,82 ± 1,23 vs. 10,02 ± 2,73; p = 0,04, β mean wave 5,33 ± 1,98 vs. 8,43 ± 3,03; p = 0,02, α mean wave 10,79 ± 4,03 vs.16,82 ± 6,38; p = 0,03). Conclusions according to the literature data, immunotherapy seems to have a safe cardiovascular profile. Anti-VEGF drugs seem to predominantly cause vascular damage, early identifiable through arterial stiffness measurement.

10.1093/ehjci/jez319.503

Cite

Citations (0)

[Dyslipidemia management with medical nutrition therapy: current status and perspectives].

PubMed (2013)

Vincenzo Sucato Oreste Fabio Triolo Enrico Bronte Rosaria Linda Trovato Giuseppe Riccardo Tona

In Italy, patients with dyslipidemia account for 15-20% of the adult population with major healthcare and socio-economic impact. According to the ESC/EAS guidelines for the management of dyslipidemias, desirable cholesterol and triglyceride levels can be achieved with a synergy between drug treatment and adequate diet therapy. However, what diets should be adopted? In this review article, different types of dietary treatments are compared, with a special focus on diet education. The new scientific frontier of nutrigenetics is also discussed.

Dyslipidemia

Dietary therapy

Medical nutrition therapy

10.1701/1331.14734

Cite

Citations (1)

P1270Effects of blood pressure variability on layer-specific longitudinal strain in hypertensionP1271 Left atrial dynamics and diastolic function in hypertensive patientsP1272Echocardiographic evaluation of right ventricular function in patients with chronic obstructive pulmonary disease in comparison with healthy groupP1273The impact of preeclampsia on myocardial recovery in women with peripartum cardiomyopahty - speckle tracking studyP1274Diagnostic accuracy of bedside lung ultrasonography in…

European Heart Journal - Cardiovascular Imaging (2016)

Wen‐Che Tsai E. Chamodraka Neda Behzadnia Krasimira Hristová A. Ledakowicz-Polak

Background: Our previous study showed sub-epicardial longitudinal strain (EpiLS) was an independent prognostic factor for worse outcome in regular treated hypertension but not global longitudinal strain (GLS) and sub-endocardial longitudinal strain (EndLS). Increased blood pressure variability (BPV) has been found associated with target organ damage in hypertension. However, effects of BPV on layer-specific longitudinal strain have not been well studied. Purpose: The aim of this study was to investigate the effects of different blood pressure parameters on layer-specific longitudinal strain in hypertension. Methods: This study included 95 patients (57 men, age 65 ± 12 years) with uncomplicated hypertension who have been regularly treated for more than 1 year. Speckle tracking echocardiography was used for measurement of longitudinal deformation from 3 apical views of left ventricle. GLS was measured by automated function imaging (AFI). We further divided into sub-endocardial and sub-epicardial myocardium and measured their longitudinal strain by manual click-and-draw method and averaged from 3 apical views. Blood pressure parameters included office systolic blood pressure (SBP), office diastolic blood pressure (DBP), central SBP and DBP by tonometry, average 24-hour SBP and DBP, and BPV parameters by ambulatory blood pressure monitor. BPV parameters included standard deviation of daytime SBP (DSSD), standard deviation of nighttime SBP (NSSD), standard deviation of daytime DBP (DDSD), and standard deviation of nighttime DBP (NDSD). Results: We divided subjects into low and high group according to median level of each strain. No blood pressure parameters were different between low and high EndLS group except week difference in NDSD (9.0 ± 3.4 vs. 7.8 ± 2.0 mmHg, p = 0.051). NSSD (11.2 ± 4.6 vs. 9.3 ± 2.9 mmHg, p = 0.027) and NDSD (9.1 ± 3.4 vs. 7.7 ± 2.0 mmHg, p = 0.031) were significant increased in low GLS group but not other parameters. DDSD (10.3 ± 3.0 vs. 9.0 ± 2.5 mmHg, p = 0.034), NSSD (11.4 ± 4.4 vs. 9.1 ± 3.1 mmHg, p = 0.006), and NDSD (9.2 ± 3.2 vs. 7.6 ± 2.2 mmHg, p = 0.012) were significantly increased in low EpiLS group. Conclusions: Only BPV parameters were associated with decreased longitudinal strain in hypertension. Effects of BPV were majorly noted in EpiLS.

Speckle tracking echocardiography

Longitudinal Study

10.1093/ehjci/jew266.002

Cite

Citations (4)

Tolerability, efficacy and acceptability of fentanyl pectin nasal spray for breakthrough cancer pain

Annals of Oncology (2016)

A. Massimiliano Giuseppe Bronte F.P. Spataro Enrico Bronte V. Leonardi

Tolerability

Nasal spray

10.1093/annonc/mdw344.14

Cite

Citations (0)

Function-based discovery of characteristic temporal expression profiles in endothelial cells stimulated with insulin

Tiziana Sanavia Barbara Di Camillo Elisabetta Iori Alberto Maran Enrico Bronte

Expression (computer science)

Source

Cite

Citations (0)

Metastatic Site Location Influences the Diagnostic Accuracy of ctDNA EGFR- Mutation Testing in NSCLC Patients: a Pooled Analysis

Current Cancer Drug Targets (2018)

Francesco Passiglia Sérgio Rizzo Christian Rolfo Antonio Galvano Enrico Bronte

Recent studies evaluated the diagnostic accuracy of circulating tumor DNA (ctDNA) analysis in the detection of epidermal growth factor receptor (EGFR) mutations from plasma of NSCLC patients, overall showing a high concordance as compared to standard tissue genotyping. However it is less clear if the location of metastatic site may influence the ability to identify EGFR mutations.This pooled analysis aims to evaluate the association between the metastatic site location and the sensitivity of ctDNA analysis in detecting EGFR mutations in NSCLC patients.Data from all published studies, evaluating the sensitivity of plasma-based EGFRmutation testing, stratified by metastatic site location (extrathoracic (M1b) vs intrathoracic (M1a)) were collected by searching in PubMed, Cochrane Library, American Society of Clinical Oncology, and World Conference of Lung Cancer, meeting proceedings. Pooled Odds ratio (OR) and 95% confidence intervals (95% CIs) were calculated for the ctDNA analysis sensitivity, according to metastatic site location.A total of ten studies, with 1425 patients, were eligible. Pooled analysis showed that the sensitivity of ctDNA-based EGFR-mutation testing is significantly higher in patients with M1b vs M1a disease (OR: 5.09; 95% CIs: 2.93 - 8.84). A significant association was observed for both EGFR-activating (OR: 4.30, 95% CI: 2.35-7.88) and resistant T790M mutations (OR: 11.89, 95% CI: 1.45-97.22), regardless of the use of digital-PCR (OR: 5.85, 95% CI: 3.56-9.60) or non-digital PCR technologies (OR: 2.96, 95% CI: 2.24-3.91).These data suggest that the location of metastatic sites significantly influences the diagnostic accuracy of ctDNA analysis in detecting EGFR mutations in NSCLC patients.

Concordance

T790M

10.2174/1568009618666180308125110

Cite

Citations (36)

Immunotherapy for recurrent ovarian cancer: a further piece of the puzzle or a striking strategy?

Expert Opinion on Biological Therapy (2013)

Giuseppe Bronte Giuseppe Cicero Giovanni Sortino Gianfranco Pernice Maria Teresa Catarella

Introduction: Treatment of ovarian cancer has been long standardized with the inclusion of surgery and chemotherapy based on platinum and taxanes, this strategy reaching high remission rates. However, when this treatment fails, further options are available with little benefit. Since ovarian cancer has specific immunologic features, actually immunotherapy is under evaluation to overcome treatment failure in patients experiencing recurrence.

Cancer Immunotherapy

Cancer Treatment

10.1517/14712598.2014.859671

Cite

Citations (7)

The prognostic role of KRAS and BRAF in patients undergoing surgical resection of colorectal cancer liver metastasis: a systematic review and meta-analysis

Annals of Oncology (2016)

Francesco Passiglia Antonio Galvano Stefania Rizzo Angela Listì Nadia Barraco

Subgroup analysis

10.1093/annonc/mdw335.08

Cite

Citations (0)