Bartłomiej Grala

Wojskowy Instytut Medycyny Lotniczej

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Tomasz Markiewicz

Poznan University of Medical Sciences

ŻŚ

Żaneta Świderska-Chadaj

Warsaw University of Technology

Wojciech Kozłowski

Wrocław University of Science and Technology

Małgorzata Lorent

Wojskowy Instytut Medycyny Lotniczej

Cezary Szczylik

Cleveland Clinic

Lubomir Bodnar

University of Siedlce

Rafał Stec

Medical University of Warsaw

J Słodkowska

Wojskowy Instytut Medycyny Lotniczej

Renata Duchnowska

Wojskowy Instytut Medycyny Lotniczej

Marta Smoter

Wojskowy Instytut Medycyny Lotniczej

Cooperative Institutions

Wojskowy Instytut Medycyny Lotniczej

Wojskowy Instytut Medyczny

Military Communication Institute

Central Clinical Hospital

Centralny Szpital Kliniczny

Medical University of Warsaw

National Academy of Medicine

Polish Academy of Sciences

Ministry of National Defense

Medical University of Lodz

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Combination of monoclonal antibody (Bevacizumab) and chemotherapy (FOLFIRI) in palliative treatment of metastatic adenocarcinoma of the small bowel (SBC): case report and review of the literature.

Archives of Medical Science (2009)

Rafał Stec Bartłomiej Grala Michał Mączewski Lubomir Bodnar Arkadiusz Żegadło

Small bowel cancer (SBC) is very rare malignancy. Annually about only 89 new cases of SBC are diagnosed in Poland (0.1-0.3%) of all malignancies and approximately 1% of gastrointestinal cancers. The prognosis of metastatic SBC is rather poor. The median survival of patients undergoing chemotherapy is approximately 14 months. Small bowel cancer is considered refractory to chemotherapy. Various anticancer agents have been tested in palliative chemotherapy of SBC: 5-Fluorouracil (5-FU), Cisplatin, Adriamycin, Mitomycin C, Oxaliplatin, Irinotecan, Carboplatin. Here we report a rare case of metastatic SBC with complete response (CR) after combination treatment with monoclonal antibody (Bevacizumab) and FOLFIRI (5-FU, Leukovorin, Irinotecan). The patient is alive without disease progression 28 months after her primary presentation of SBC.

FOLFIRI

Carboplatin

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New automated image analysis method for the assessment of Ki-67 labeling index in meningiomas.

Folia Histochemica et Cytobiologica (2010)

Bartłomiej Grala Tomasz Markiewicz Wojciech Kozłowski S. Osowski J Słodkowska

Many studies have emphasised the importance of Ki-67 labeling index (LI) as the proliferation marker in meningiomas. Several authors confirmed, that Ki-67 LI has prognostic significance and correlates with likelihood of tumour recurrences. These observations were widely accepted by pathologists, but up till now no standard method for Ki-67 LI assessment was developed and introduced for the diagnostic pathology. In this paper we present a new computerised system for automated Ki-67 LI estimation in meningiomas as an aid for histological grading of meningiomas and potential standard method of Ki-67 LI assessment. We also discuss the concordance of Ki-67 LI results obtained by presented computerized system and expert pathologist, as well as possible pitfalls and mistakes in automated counting of immunopositive or negative cells. For the quantitative evaluation of digital images of meningiomas the designed software uses an algorithm based on mathematical description of cell morphology. This solution acts together with the Support Vector Machine (SVM) used in the classification mode for the recognition of immunoreactivity of cells. The applied sequential thresholding simulated well the human process of cell recognition. The same digital images of randomly selected tumour areas were parallelly analysed by computer and blindly by two expert pathologists. Ki-67 labeling indices were estimated and the results compared. The mean relative discrepancy between the levels of Ki-67 LI by our system and by the human expert did not exceed 14% in all investigated cases. These preliminary results suggest that the designed software could be an useful tool supporting the diagnostic digital pathology. However, more extended studies are needed for approval of this suggestion.

Grading (engineering)

Digital Image Analysis

Ki-67

Concordance

Automated method

Proliferation index

Image Analysis

10.2478/v10042-008-0098-0

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Citations (37)

[Elimination of indocyanine green (ICG) in liver diseases following increased dye loading and prolonged time of measurements].

PubMed (1976)

Jacek Juszczyk Bartłomiej Grala J Adamek A Kryska M Panczyszak

Indocyanine Green

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Papillary tumor of the pineal region. Report of two cases and literature review

Neurologia i Neurochirurgia Polska (2014)

Andrzej Koziarski Bartłomiej Grala Ewa Skrobowska

Papillary tumor

10.1016/j.pjnns.2014.09.005

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Citations (12)

Long-Term Remission after Erlotinib Therapy in an Elderly Patient with Advanced Non-small Cell Lung Cancer. Case Report and Conclusions for Clinical Practice

Advances in respiratory medicine (2008)

Renata Duchnowska Anna M. Siemiatkowska Bartłomiej Grala Marta Smoter

Small molecule tyrosine kinase inhibitors (TKIs) of epidermal growth factor receptor (EGFR) - gefitinib and erlotinib - have recently been used as a therapeutic option in advanced non-small cell lung cancer (NSCLC) patients relapsing after first- or second-line chemotherapy. We report here a case of long-term remission in an elderly, non-smoking woman with advanced NSCLC after chemotherapy failure, who was selected for erlotinib therapy using demographic and clinical criteria. Based on this example and on the literature data we discuss the need for careful patient selection for this new therapeutic method.

Erlotinib Hydrochloride

10.5603/arm.27862

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Citations (1)

Additional file 1: of Content-based analysis of Ki-67 stained meningioma specimens for automatic hot-spot selection

Figshare (2016)

Żaneta Świderska-Chadaj Tomasz Markiewicz Bartłomiej Grala Małgorzata Lorent

The results of the manual and automatic Ki-67 index evaluation for each of cases. (XLSX 16Â kb)

Content (measure theory)

10.6084/m9.figshare.c.3618392_d1

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Tumor of the Nose – A Rare Manifestation of a Metastatic Lung Cancer

Clinical Cosmetic and Investigational Dermatology (2021)

Aleksandra Bolewska Monika Słowińska Agata Błońska Justyna Ceryn Bartłomiej Grala

Abstract: Lung cancer most often metastasizes to the central nervous system, bone and liver. Although metastases to the skin are quite rare, it is estimated that they may be the first clinical manifestation of this disease in 0.7%– 12% of cases. Metastases to the skin are caused by adenocarcinoma (about 30%), squamous cell carcinoma (30%) and undifferentiated carcinoma (40%). Nasal tip metastases are extremely rare. They can be confused with more common skin problems, including non-melanoma skin cancers, rhinophyma, inflammatory tumors or infectious diseases. We report two patients with a tumor on the nose, which proved to be the first sign of the metastatic lung cancer. Keywords: lung cancer, skin metastasis, ulceration, tumor

10.2147/ccid.s318748

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Citations (4)

The role of Tau protein in resistance to paclitaxel

Cancer Chemotherapy and Pharmacology (2011)

Marta Smoter Lubomir Bodnar Renata Duchnowska Rafał Stec Bartłomiej Grala

Resistance to taxanes, related to limited efficacy of systemic therapy in cancer patients, is multifactorial. Among mechanisms of resistance to taxanes, those related to microtubule-associated proteins (MAP), including protein Tau, are of great importance. Protein Tau (50–64 kD) binds to beta-tubulin in the same place as paclitaxel. In preclinical studies, low expression of Tau in cancer cells was associated with increased sensitivity to paclitaxel. High expression of Tau protein in ER-positive breast cancers indicates resistance to taxane-containing chemotherapy and sensitivity to hormonal treatment. This article reviews current knowledge on predictive value of protein Tau in response to taxanes. Better understanding of its role may facilitate patients selection to this sort of treatment and lead to treatment optimization.

Taxane

Tau protein

10.1007/s00280-011-1696-7

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Citations (67)

Stewart-Treves syndrome angiosarcoma expresses phenotypes of both blood and lymphatic capillaries

Chinese Medical Journal (2013)

Marek Stańczyk Magdalena Gewartowska Marcin Świerkowski Bartłomiej Grala Marek Maruszyński

Background The development of angiosarcoma in oedematous tissue is referred to as Stewart-Treves syndrome (STS). This rare and fatal complication is associated with chronic post mastectomy lymphoedema and radiotherapy for breast cancer. Angiosarcoma spread is facilitated by the formation of blood vessels (angiogenesis) and lymph vessels (lymphangiogenesis). In the future antiangiogenic therapy may improve the poor outcome of current treatments. There was evidence that blocking the angiogenenesis would inhibit progression of angiosarcoma. It seems reasonable to hypothesize that blocking the lymphangiogenesis may yield similar results. Although angiosarcomas commonly derive from blood vessels, in case of STS angiosarcomas chronic lymphoedema may suggest its lymphatic origin. The goal of this study was to visualize interstitial space and lymphatics in the central and peripheral regions of STS angiosarcoma. Methods On tissue samples obtained from STS angiosarcoma we have performed: first colour stereoscopic lymphography to visualise the morphology of lymphatic vessels and extracellular spaces, second immunohistochemical staining specific for lymphatic vessels endothelium (LYVE-1) and blood endothelial cells (CD31, factor VIII) and prolymphangiogenic vascular endothelial growth factor (VEGF-C) for precise identification of lymphatic endothelia. STS angiosarcoma morphology was assessed by comparison of pictures obtained on lymphography, microscopy and confocal microscopy. Results STS angiosarcomas present heterogenous morphology with areas dominated by hemangiosarcoma and lymphangiosarcoma structures. STS angiosarcoma expressed phenotypes of both blood and lymphatic endothelia. LYVE-1 and VEGF-C is expressed by STS angiosarcoma and may be used to discriminate tumour differentiation. Morphology of lymphatic vessels and spaces in the tumour suggest absence of their normal lymphatic function. Conclusions Our results confirmed both hemangio- and lymphangiogenic origin of STS angiosarcoma. Expression of VEGF-C makes STS angiosarcoma a good candidate for targeted antilymphangiogenic therapy. However, morphology of intratumoral lymphatics on colour lymphography suggested their impaired function, which can hamper drug distribution.

Lymphangiogenesis

Hemangiosarcoma

CD31

Lymphatic Endothelium

10.3760/cma.j.issn.0366-6999.20120993

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Citations (13)

New automated image analysis method for the assessment of Ki-67 labeling index in meningiomas.

DOAJ (DOAJ: Directory of Open Access Journals) (2010)

W Papierz J Słodkowska S. Osowski Wojciech Kozłowski Tomasz Markiewicz

10.5603/4304

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Citations (2)