Paolo Conti

University of Perugia

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Elena Toniato

University of Chieti-Pescara

A. Caraffa

Università di Camerino

Filippo Aucella

Casa Sollievo della Sofferenza

P. Antinolfi

University of Perugia

S. Frydas

Aristotle University of Thessaloniki

Matteo Scarponi

University of Southampton

Giulia Pascoletti

University of Perugia

Francesco Bianconi

University of Perugia

R.A. Shenoi

University of Southampton

Stephen R. Turnock

University of Southampton

Cooperative Institutions

University of Chieti-Pescara

Istituti di Ricovero e Cura a Carattere Scientifico

Società Italiana di Nefrologia

Sapienza University of Rome

University of Milan

University of Perugia

University of Padua

University of Bari Aldo Moro

Ospedale SS. Annunziata

University of Campania "Luigi Vanvitelli"

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RANTES and MCP-1 secretion by mononuclear cells of patients with multiple sclerosis

Journal of Neuroimmunology (1998)

Gabriele C. DeLuca Marcella Reale Carla Iarlori Alessandra Lugaresi Paolo Conti

10.1016/s0165-5728(98)91606-x

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Citations (1)

Interleukin-17 and the interleukin-17 family member network.

PubMed (2004)

Huang Sh S. Frydas D. Kempuraj Barbacane Rc Alfredo Grilli

Interleukin-17 (now known as IL-17A), is a homodimer of two 155 amino acid chains secreted by CD4+ activated memory T cells (CD45+ RO+) and is available as a glycosylated 20- to 30-kDa homodimeric peptide. Human IL-17 shows amino acid sequence identity of 62.5 and 58% to the mouse and rat sequences, respectively. IL-17 can regulate the function of a variety of cell types, plays an important role in the maturation of hematopoietic progenitor cells, and induces production of proinflammatory mediators. Here, for the first time, we summarize the biological effects of IL-17 and its family members as important players of T cell-mediated immune responses and underline the important implications of this cytokine in inflammation and degenerative diseases.

Proinflammatory cytokine

Interleukin 3

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Safety and efficacy of COVID-19 vaccines in patients on dialysis: a multicentre cohort study in Italy

Journal of Nephrology (2023)

Francesca Menniti‐Ippolito Alfonso Mele Roberto Da Salvatore De Masi Flavia Chiarotti

Case fatality rate

Rate ratio

10.1007/s40620-023-01708-7

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Citations (3)

Experimental study and finite element analysis of the elastic instability of composite lattice structures for aeronautic applications

Composite Structures (2006)

E. Frulloni J. M. Kenny Paolo Conti Luigi Torre

Hydrostatic equilibrium

Lattice (music)

Hydrostatic pressure

10.1016/j.compstruct.2005.11.013

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Citations (72)

ENOX2 (or tNOX): a new and old molecule with cancer activity involved in tumor prevention and therapy.

PubMed (2016)

Gianpaolo Ronconi Gianfranco Lessiani Enrico Spinas Spyridon K. Kritas A. Caraffa

Cancer includes a number of related diseases due to abnormal cell proliferation that spreads to nearby tissues. Many compounds (physical, chemical and biological) have been used to try to halt this abnormal proliferation, but the therapeutic results are poor, due also to the side effects. It has been reported that ecto-nicotinamide adenine dinucleotide oxidase di-sulfide-thiol exchanger 2 (ENOX2), also known as tumor-associated nicotinamide adenine dinucleotide oxidase (tNOX), was found to be located on the cancer cell surface, essential for cancer cell growth. Capsaicin and other anti-oxidants are capable of inhibiting tNOX, causing apoptosis of cells, exerting anti-tumor activity. It is interesting that some authors reported that ENOX2 is present in the serum of cancer patients several years before the clinical symptoms of the tumor. However, this result has to be confirmed. In this article we discuss ENOX2 and its inhibition as a hope of improving cancer therapy.

Cancer Therapy

Flavin adenine dinucleotide

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Letter to Editor: Chemokine Network Involved in Inflammatory Skin Diseases.

PubMed (2015)

Y.B. Shaik-Dasthagirisaheb Paolo Conti

Chemokines are low-molecular-weight chemotactic proteins that regulate the trafficking of leukocytes to inflammatory sites and may recruit inflammatory cells to the epidermis. Chemokines are produced by many immune cells such as macrophages, mast cells, T lymphocytes and others, in response to pro-inflammatory stimuli including IL-1, TNF and LPS. Immune cells which participate in inflammatory skin disorders, upon activation express several adhesive and immune receptors such as P-selectin, CD40 ligand, and Toll-like receptors on their surface, and generate cytokines/chemokines. Chemokines have crucial functions in inflammation, and cell dysregulations and they are recognized as potentially important in diverse skin pathologies associated with the severity of disease. Injection of chemokines in the rat skin provoke the recruitment of inflammatory cells, release of cytokines, and activation of transcription of histidine decarboxylase (HDC), the enzyme responsible for the generation of histamine from histidine, which may cause fatal anaphylactic shock. Therefore, the use of anti-chemokines for inflammatory skin diseases remains a promising therapeutic approach. However, the complete role of chemokines in inflammatory skin diseases remains to be further studied. Here we report the relationship between chemokines and skin inflammation.

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A Cardio-Synchronized Injection System

Advances in Bioengineering (2000)

Paolo Conti Lucio Banetta A. Ficola F. Magnino

Abstract The main limit in today’s infusion systems is that they can yield high liquid volumes but at low velocity (gravity systems) or at some higher velocity, but with constant mass/velocity ratio (peristaltic systems). In any case, the blood injection is obtained without any synchronization with fast ventricular diastole nor any attempt is made to enhance blood circulation in the venous vessels (which can be drastically slowed down by the pressure drop in the circulatory system); this can induce non physiologic pressure rises in the central venous system. A prototypical cardio-synchronized injection system has been developed in order to avoid the negative effects of continuos high rate infusion, to allow a mass injection independent from the velocity, and to induce a pumping effect in the venous vessels. The system has been designed to reduce the impact on the central venous pressure and to allow lower mass injection at higher velocities.

Venous return curve

10.1115/imece2000-2637

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Drug Design Approaches to Manipulate the Agonist-Antagonist Equilibrium in Steroid Receptors

InTech eBooks (2012)

J. Scott Paolo Conti Wim H.A. Dokter Hélio Pedro Jacob de

The steroid hormone receptors, the Androgen Receptor (AR), Estrogen Receptors (ER┙ and ER┚), Glucocorticoid Receptor (GR), Mineralocorticoid Receptor and Progesterone Receptor (PR), have been crucial targets for drug discovery even before their existence was known or understood. The drugs on the market for this sub-class of the nuclear hormone receptors constitute a significant pharmacopeia for the treatment of a vast array of conditions and ailments. Despite the breadth of drugs targeted toward this family, they remain an important target for the pharmaceutical industry. Key considerations when designing drugs for any family, beyond the on-target pharmaceutical action and safety, is to ensure specificity against related targets, exploration of the most appropriate routes of administration and desirable pharmacokinetic (PK) profiles. Developing non-steroidal modulators for the steroid receptor family has been a key strategy employed to achieve these goals, although there appears to be growing consensus that not being steroidal is insufficient to justify new drugs on its own (Hermkens et al, 2006). Unlike targeting many families, steroid hormone receptor drug discovery also has to balance the need to elicit either agonistic or antagonistic responses depending on the desired indication. The history of drug discovery for the steroid hormone receptors has tended to follow a common path, beginning with the application of purified endogenous hormone and followed by the application of the first synthetic analogs with improved PK properties or selectivity. For some of the receptors this period was followed by the design of antagonists, including non-steroidal structures. More recently, steroid hormone drug discovery has been

Steroid hormone

10.5772/28124

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Citations (4)

'Robo-Yacht : A human behaviour-based tool to predict the performances of yacht-crew systems'

PsycEXTRA Dataset (2007)

Matteo Scarponi T. McMorris R.A. Shenoi Stephen R. Turnock Paolo Conti

Many numerical tools are available in the yacht design domain to predict yacht performances. These are based on experimental data and well-established numerical techniques. However, being competitive sailing an uncertainty-rich discipline, there is also a need to assess the performances of a yacht’s crew. This is indeed the main area for performance gains. The present study aims at predicting the performances of yacht-crew systems, by including numerical models for human behaviour within those referred to the yacht dynamics. In particular, the problem of decision-making under weather uncertainty is formulated in terms of a game of chance having nature as a second player and involving risk. Within this context, it is shown that decisionmaking models often used in management sciences can be advantageously used. This approach has led to the development of a sailing simulator referred to as ‘Robo-Yacht’, based on the International America’s Cup Class. A case study is investigated that involves three strategical alternatives and four possible weather scenarios: gains and losses are assessed through the simulator and a formula to express expected payoffs is derived. When different attitudes towards risk (neutral, risk-averse and risk-taking) are expressed as different utility functions, it is shown that sailors’ choices can be conveniently modeled based on a maximization of expected utility. The ‘automatic crew’ can actually make decisions that appear to be consistent with widely accepted principles of race strategy. A risk function is also derived in order to take into account opponents’ choices and, where necessary, modify the strategic plan accordingly.

10.1037/e548052012-436

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Conjugated Linoleic Acid: A Functional Food?

International Journal of Immunopathology and Pharmacology (2003)

Nicolantonio D’Orazio C. Ficoneri Graziano Riccioni Paolo Conti Theoharis C. Theoharides

Scientific interest in conjugated linoleic acid (CLA) started in 1987 when Michael Pariza's team of Wisconsin University observed its inhibitory effects on chemically induced skin tumors in mice. Numerous studies have since examined CLA's role in cancer, immune function, oxidative stress, atherosclerosis, lipid and fatty acids metabolism, bone formation and composition, obesity, and diabetes. Still it's not clear yet either through which mechanisms CLA produces its numerous metabolic effects. We now know that CLA contents in cow milk fat can be enriched through dry fractionation, but this knowledge doesn't allow sufficient certainty to qualify this nutrient, as a functional food, capable of increasing well being and reducing the risk of disease.

Functional food

10.1177/039463200301600305

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Citations (12)