Timothy J. J. Inglis

Queen Elizabeth II Medical Centre

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Adam J. Merritt

Pathwest Laboratory Medicine

Barbara J. Chang

University of Western Australia

Nicole M. Bzdyl

University of Western Australia

Nadia Urosevic

University of Western Australia

Kieran T. Mulroney

University of Western Australia

Max Aravena-Román

University of Western Australia

Avram Levy

Queen Elizabeth II Medical Centre

Lyn C. O'Reilly

Pathwest Laboratory Medicine

Teagan F. Paton

Harry Perkins Institute of Medical Research

Aron Chakera

Sir Charles Gairdner Hospital

Cooperative Institutions

University of Western Australia

Queen Elizabeth II Medical Centre

Pathwest Laboratory Medicine

Sir Charles Gairdner Hospital

Chinese Academy of Sciences

University of Sydney

University of Melbourne

University of Queensland

Government of Western Australia Department of Health

Tsinghua University

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Co-selection may explain high rates of ciprofloxacin non-susceptible Escherichia coli from retail poultry reared without prior fluoroquinolone exposure

Journal of Medical Microbiology (2013)

Paul R. Ingram Benjamin A. Rogers Hanna E. Sidjabat Justine S. Gibson Timothy J. J. Inglis

Australia has never permitted fluoroquinolone use in food-producing animals. We examined local retail poultry for contamination with fluoroquinolone non-susceptible Escherichia coli, then explored the hypothesis that their presence may be due to co-selection of resistance determinants. Between August and November 2010, samples from 30 locally produced, uncooked retail poultry carcasses from four different processing centres underwent selective enrichment culture for ciprofloxacin non-susceptible E. coli. Their chromosomal- and plasmid-mediated resistance determinants were characterized, and phylogenetic analysis and transformation experiments were performed. Unexpectedly, we found nine (30 %) of our small collection of poultry samples carried fluoroquinolone non-susceptible E. coli of which nearly half possessed aac(6')-Ib-cr, a novel plasmid-mediated gene encoding an aminoglycoside acetylating enzyme that also confers fluoroquinolone resistance. All nine isolates were co-resistant to amoxicillin, gentamicin, tetracycline and trimethoprim/sulfamethoxazole--all antibiotic classes that are registered for use in poultry reared for food production within Australia. Their unique phylogenetic relatedness suggested clonal dissemination driven by non-fluoroquinolone selective pressures. aac(6')-Ib-cr was successfully transformed and selected for using non-fluoroquinolone antibiotic pressure. Vertical and perhaps horizontal co-selection may be contributing to the emergence of fluoroquinolone resistance in poultry and could play a similar role in the human setting. This suggests that preservation of the usefulness of fluoroquinolones may require more than just restriction of their use in isolation from other interventions.

Poultry farming

10.1099/jmm.0.062729-0

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Citations (28)

WS-10-1 The development of conduction block in human axons

Electroencephalography and Clinical Neurophysiology/Electromyography and Motor Control (1995)

David Burke Timothy J. J. Inglis Simon C. Gandevia

10.1016/0924-980x(95)92532-q

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Citations (1)

High-level quinolone resistance in Pseudomonas aeruginosa

Journal of Antimicrobial Chemotherapy (1992)

Laura J. V. Piddock Shweta Panchal Timothy J. J. Inglis Peter M. Hawkey

Journal Article High-level quinolone resistance in Pseudomonas aeruginosa Get access L. J. V. PIDDOCK, L. J. V. PIDDOCK aAntimicrobial Agents Research Group, Department of Infection, University of BirminghamBirmingham, B15 2TT Search for other works by this author on: Oxford Academic PubMed Google Scholar S. PANCHAL, S. PANCHAL aAntimicrobial Agents Research Group, Department of Infection, University of BirminghamBirmingham, B15 2TT Search for other works by this author on: Oxford Academic PubMed Google Scholar T. J. J. INGLIS, T. J. J. INGLIS bDepartment of Microbiology, The University of LeedsLeeds LS2 9JT, UK Search for other works by this author on: Oxford Academic PubMed Google Scholar P. M. HAWKEY P. M. HAWKEY bDepartment of Microbiology, The University of LeedsLeeds LS2 9JT, UK Search for other works by this author on: Oxford Academic PubMed Google Scholar Journal of Antimicrobial Chemotherapy, Volume 30, Issue 2, August 1992, Pages 229–230, https://doi.org/10.1093/jac/30.2.229-a Published: 01 August 1992

Quinolone

Antimicrobial chemotherapy

10.1093/jac/30.2.229-a

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Rapid susceptibility profiling of carbapenem-resistant Klebsiella pneumoniae

Scientific Reports (2017)

Kieran T. Mulroney Jarrad M. Hall Xiaoshui Huang E. Turnbull Nicole M. Bzdyl

The expanding global distribution of multi-resistant Klebsiella pneumoniae demands faster antimicrobial susceptibility testing (AST) to guide antibiotic treatment. Current ASTs rely on time-consuming differentiation of resistance and susceptibility after initial isolation of bacteria from a clinical specimen. Here we describe a flow cytometry workflow to determine carbapenem susceptibility from bacterial cell characteristics in an international K. pneumoniae isolate collection (n = 48), with a range of carbapenemases. Our flow cytometry-assisted susceptibility test (FAST) method combines rapid qualitative susceptible/non-susceptible classification and quantitative MIC measurement in a single process completed shortly after receipt of a primary isolate (54 and 158 minutes respectively). The qualitative FAST results and FAST-derived MIC (MICFAST) correspond closely with broth microdilution MIC (MICBMD, Matthew's correlation coefficient 0.887), align with the international AST standard (ISO 200776-1; 2006) and could be used for rapid determination of antimicrobial susceptibility in a wider range of Gram negative and Gram positive bacteria.

Broth microdilution

Carbapenem

Carbapenem-resistant enterobacteriaceae

10.1038/s41598-017-02009-3

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Citations (48)

The Lab Without Walls: A Deployable Approach to Tropical Infectious Diseases

American Journal of Tropical Medicine and Hygiene (2013)

Timothy J. J. Inglis

The Laboratory Without Walls is a modular field application of molecular biology that provides clinical laboratory support in resource-limited, remote locations. The current repertoire arose from early attempts to deliver clinical pathology and public health investigative services in remote parts of tropical Australia, to address the shortcomings of conventional methods when faced with emerging infectious diseases. Advances in equipment platforms and reagent chemistry have enabling rapid progress, but also ensure the Laboratory Without Walls is subject to continual improvement. Although new molecular biology methods may lead to more easily deployable clinical laboratory capability, logistic and technical governance issues continue to act as important constraints on wider implementation.

Clinical Microbiology

10.4269/ajtmh.12-0704

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The effects of vestibular stimulaton on hemineglect: implications for rehabilitation

Physical Therapy Reviews (1997)

Andrea Cleaves Timothy J. J. Inglis

Hemineglect poses a significant impediment to functional rehabilitation post brain injury. Caloric stimulation, a form of vestibular stimulation, has been shown to improve neglect. The purpose of this paper is to review the neglect phenomenon, to examine the literature on the effects of vestibular stimulation on hemineglect, and to outline possible treatment strategies for the management of neglect. Of the various models, the majority of the literature supports the theory that neglect is a representational deficit. Manifestations of neglect are affected by vestibular stimulation. All examined studies demonstrated a transient reduction in left neglect following caloric stimulation. This indicates that vestibular stimulation may become a powerful tool in the treatment of patients with hemineglect. The potential of other forms of stimulation are also explored. Based on the results of this review, it is recommended that further studies be conducted to determine the most practical and effective application of vestibular stimulation.

Caloric theory

Acquired brain injury

10.1179/ptr.1997.2.4.185

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Marginal notes, October 2022. The passing of generations

Journal of Medical Microbiology (2022)

Timothy J. J. Inglis

Microbiology Society journals contain high-quality research papers and topical review articles. We are a not-for-profit publisher and we support and invest in the microbiology community, to the benefit of everyone. This supports our principal goal to develop, expand and strengthen the networks available to our members so that they can generate new knowledge about microbes and ensure that it is shared with other communities.

Clinical Microbiology

10.1099/jmm.0.001626

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Citations (0)

MARGINAL NOTES, December 2023: Sepsis waits for no-one

Journal of Medical Microbiology (2024)

Timothy J. J. Inglis

Clinical Microbiology

10.1099/jmm.0.001798

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MARGINAL NOTES, August, 2023. Something in the air

Journal of Medical Microbiology (2023)

Timothy J. J. Inglis

10.1099/jmm.0.001752

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The Impact of Chronic Kidney Disease and Short-Term Treatment with Rosiglitazone on Plasma Cell-Free DNA Levels

PPAR Research (2014)

Amanda L. McGuire Nadia Urosevic Doris Chan Gursharan Dogra Timothy J. J. Inglis

Patients with chronic kidney disease (CKD) are at increased risk of cardiovascular disease. Circulating free nucleic acids, known as cell-free DNA (cfDNA), have been proposed as a novel biomarker of cardiovascular risk. The impact of renal impairment on cfDNA levels and whether cfDNA is associated with endothelial dysfunction and inflammation in CKD has not been systematically studied. We analysed cfDNA concentrations from patients with varying degrees of CKD. In addition, to determine whether there is a relationship between cfDNA, inflammation, and endothelial dysfunction in CKD, levels of proinflammatory cytokines and von Willebrand Factor (vWF) were measured in patients treated with the peroxisome proliferator-activated receptor gamma agonist rosiglitazone or placebo for 8 weeks. cfDNA levels were not increased with renal impairment or associated with the degree of renal dysfunction (P = 0.5). Treatment with rosiglitazone for 8 weeks, but not placebo, was more likely to lead to a reduction in cfDNA levels (P = 0.046); however, the absolute changes in cfDNA concentrations during treatment were not statistically significant (P > 0.05). cfDNA levels correlated with markers of endothelial dysfunction (hsCRP P = 0.0497) and vWF (P = 0.0005). In conclusion, cell-free DNA levels are not influenced by renal impairment but do reflect endothelial dysfunction in patients with CKD.

Rosiglitazone

10.1155/2014/643189

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Citations (19)