José Vicente Bagán Sebastián

Universitat de València

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Miguel Peñarrocha Diago

Universitat de València

Leticia Bagán

Universitat de València

Yolanda Jiménez

Instituto Maimónides de Investigación Biomédica de Córdoba

Crispian Scully

University College London

Yolanda Jiménez Soriano

Centre d'Investigacions sobre Desertificació

Enrique Lloria de Miguel

Universitat de València

Francisco Javier Silvestre Donat

Hospital Universitario Doctor Peset

Rafael Poveda

Moorpark College

Judith Murillo

Hospital General Universitario De Valencia

MÁ

Ma Ángeles Milián Masanet

Hospital General Universitario De Valencia

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Universitat de València

234

Hospital General Universitario De Valencia

164

Hospital Clínico Universitario de Valencia

Instituto de Salud Carlos III

Chinese Academy of Medical Sciences & Peking Union Medical College

Chinese Academy of Sciences

Hospital Universitari i Politècnic La Fe

Centro de Investigación Biomédica en Red

Centro de Investigación Biomédica en Red de Cáncer

Stomatology Hospital

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Recent advances in Oral Oncology 2007: Epidemiology, aetiopathogenesis, diagnosis and prognostication

Oral Oncology (2008)

José Vicente Bagán Sebastián Crispian Scully

10.1016/j.oraloncology.2008.01.008

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Citations (131)

Displasia fibrosa de los maxilares: presentación de siete casos clínicos

Medicina oral (1998)

Francisco Cardona Tortajada José Vicente Bagán Sebastián Enrique Lloria de Miguel Yolanda Jiménez Soriano Ma Ángeles Milián Masanet

espanolSe presentan siete casos de displasia fibrosa de los maxilares, cinco en pacientes del sexo masculino y dos del sexo femenino. Las mujeres presentaron las dos una displasia fibrosa facial. Uno de los pacientes varones tenia igualmente una displasia fibrosa facial, mientras que los cuatro restantes estaban afectos de una displasia fibrosa monostotica, uno de el los mandibular. La edad de nuestros casos estaba comprendida entre los 24 y los 65 anos. La mayoria de los pacientes estaban as intomaticos; unicamente los casos 3 y 6 referian alguna sintomatologia, como parestesias y dolores inespecificos; tambien era manifiesto cierto grado de deformidad extraoral en los casos de displasia fibrosa facial, y todos los casos presentaban deformidad a la exploracion intraoral. EnglishSeven cases of maxillary fibrous dysplasia are reportee/ (5 males and 2 Jemales). One male pafienf also presentedfacial fibrous dysplasia, while rhe remaining four had monosrotic fibrous dysplasia ( one of them mandibular). Parient age ranged from 24 to 65 years. Most of rhe parients were asympromaric; only cases 3 and 6 referred symproms in rhe form of paresrhesias and nonspecific pain. A degree of exfraoral deformation was also manifesr in the parients wirhfacialfibrous dysplasia, and explorafion revealed infraoral deformafion in ali cases.

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Serum levels of RANKL and OPG, and the RANKL/OPG ratio in bisphosphonate-related osteonecrosis of the jaw: Are they useful biomarkers for the advanced stages of osteonecrosis?

Medicina oral, patología oral y cirugía bucal (2017)

Leticia Bagán Yolanda Jiménez M Leopoldo Ana Laura Rubert José Vicente Bagán Sebastián

Background: We determined whether serum levels of Receptor Activator for Nuclear Factor κ B Ligand (RANKL), Osteoprotegerin (OPG), and the RANKL/OPG ratio could be useful biomarkers for the severity of oral lesions in bisphosphonate-related osteonecrosis of the jaw (BRONJ).Material and Methods: A case-control study in which Group 1 consisted of 41 patients with BRONJ due to bisphosphonates, and Group 2 consisted of 44 healthy control cases.The plasma levels of RANKL and OPG were analyzed by an ELISA assay.The OPG/RANKL ratio was also calculated.We determined if the mean serum values differed among the different stages of BRONJ.Results: Serum levels of RANKL were lower in Group 1 than in Group 2 (p =0.01), and serum levels of OPG were higher in patients with BRONJ than in the controls (p =0.006).The ratio of RANKL/OPG was greater in the controls than in Group 1 (p >0.01).There were no significant differences in the serum levels of RANKL and OPG among the different stages of osteonecrosis (p >0.05).Conclusions: Serum levels of RANKL and OPG, and the RANKL/OPG ratio were not valuable biomarkers for determining the severity of oral lesions in patients with BRONJ.

10.4317/medoral.22128

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Citations (19)

Estudio ultraestructural del liquen plano oral: Análisis de diez casos

Archivos de odontoestomatología (1988)

José Vicente Bagán Sebastián Amando Peydró Olaya Francisco Vera‐Sempere

Se presenta un estudio morfologico ultraestructural acerca de diez casos de liquen plano de mucosa oral. Senalamos la existencia de cambios morfologicos tanto a nivel de los queratinocitos basales como en el espacio extracelular. Asimismo, se encuentran frecuentes alteraciones a nivel de la lamina basal, con fenomenos de reduplicacion o aparicion de defectos de continuidad. Se comenta el papel que estos cambios a nivel de la lamina basal pueden jugar en el trasiego de elementos celulares relacionados con la inmunidad celular (linfocitos T, celulas Langerhans) y que expresan la existencia de mecanismos inmunes a la genesis de este proceso.

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Risk of developing BRONJ among patients exposed to intravenous bisphosphonates following tooth extraction

Quintessence International (2014)

José M. Sanchis José Vicente Bagán Sebastián Judith Murillo José María Díaz Fernández Lucía Asensio

Objective: A study was designed to measure of the incidence of bisphosphonate-related osteonecrosis of the jaws (BRONJ) following tooth extraction in patients receiving or who have received intravenous bisphosphonates (Zometa, zoledronic acid). Method and Materials: A prospective cohort study was made of 36 patients subjected to 62 tooth extractions. All these 36 patients had been treated or were receiving treatment with zoledronic acid. Results: The incidence of BRONJ following 62 tooth extractions in patients treated with zoledronic acid 4 months after extraction was 14.5%. Conclusion: No statistically significant associations were found with patient age, sex, hygiene index, total treatment time, surgical difficulty, or extraction site. However, the factors that significantly influenced the final presence of osteonecrosis were related to tooth extractions in the absence of periodontal disease, and if sockets remained unhealed at the month of extraction.

Zoledronic Acid

Dental extraction

10.3290/j.qi.a32243

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Cowden syndrome: a clinical case with oral lesions

Anales de Medicina Interna (2001)

R. Almenar Besó José Vicente Bagán Sebastián Ma Ángeles Milián Masanet Yolanda Jiménez Soriano

Cowden syndrome

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Erythema multiforme: diagnosis, clinical manifestations and treatment in a retrospective study of 22 patients

Journal of Oral Pathology and Medicine (2010)

J.M. Sanchis José Vicente Bagán Sebastián Carmen Gavaldá Judith Murillo José María Díaz Fernández

Erythema multiforme (EM) is an acute disorder of the skin and mucosal membranes manifesting in the oral cavity (60-70% of all patients) as polymorphic erosive, ampullar, and bloodstained crusts. The etiology is unclear, although an autoimmune mechanism is involved. Infections and drugs have been implicated in the etiopathogenesis. With the exception of corticosteroids, no specific treatment for EM is available.Data were collected on the clinical manifestations, antecedents of viral infection, and the use of drugs substances as possible etiological factors, treatment, and response to topical and systemic corticotherapy.A total of 22 patients were studied (14 males and 8 females), with a mean age of 47±20.4 years. A relationship was clearly suspected between drug use and lesion outbreak in 6 patients (27.2%). On the contrary, in 7 patients (31.8%) the triggering factor could have been herpes virus infection (herpes labialis). One half of the patients (11 cases) were classified as presenting minor EM, 36.4% (8 cases) presented major forms of the disease, and 13.6% (3 cases) were classified as corresponding to Stevens-Johnson syndrome. Systemic and/or topical corticosteroids proved effective in controlling the outbreaks in all of our patients.The oral mucosa is the most affected mucosal region in EM, with a predilection for the lip mucosa, erosive forms and bloodstained crusts. Systemic corticosteroids are effective in controlling the outbreaks, although their use as maintenance therapy is not clearly indicated.

Etiology

Erythema multiforme

Herpes Labialis

Oral mucosa

Erythema

Pharmacotherapy

10.1111/j.1600-0714.2010.00912.x

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Citations (43)

Issue Information

Oral Diseases (2020)

Anwar R. Tappuni Stephen Challacombe Irna Sufi David Croser Giovanni Lodi

10.1111/odi.13587

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Author response for "Oral leukoplakia diagnosis and treatment in Europe and Australia: Oral Medicine Practitioners' attitudes and practice"

Monica Pentenero Samuele Sutera Giovanni Lodi José Vicente Bagán Sebastián Camile S. Farah

Oral leukoplakia

Oral medicine

10.1111/odi.14301/v2/response1

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Efficacy of mometasone furoate microemulsion in the treatment of erosive‐ulcerative oral lichen planus: pilot study

Journal of Oral Pathology and Medicine (2004)

J.M. Aguirre José Vicente Bagán Sebastián Carlos Rodríguez Yolanda Jiménez Rafael Rodríguez Martínez-Conde

Background: Oral lichen planus (OLP) is a frequent immunological chronic disease, having different clinical forms: asymptomatic and symptomatic. Symptomatic OLP has been palliated with topical corticosteroids with different levels of efficacy and safety. The purpose of this pilot phase II clinical trial was to determine the efficacy of mometasone furoate microemulsion upon the symptoms and signs of erosive‐ulcerative OLP. Methods: Forty‐nine patients with clinical and histologically confirmed erosive‐ulcerative OLP were enrolled in this study (36 women and 13 men). Their average age was 56.4 years (from 28 to 78). The treatment consisted of 0.1% mometasone furoate microemulsion mouthwash three times a day over 30 days. Pain, erythema and ulceration were assessed after 15 and 30 days of treatment. The data was processed and statistically analysed by student's t ‐test for paired samples. Results: Mometasone caused a statistically significant reduction in pain (3.58 vs. 0.65, P = 0.0000). Treatment significantly reduced the surface area of erythema (155.2 vs. 21.9 mm 2 , P = 0.0001) and ulceration (30.7 vs. 7.3 mm 2 , P = 0.0000). None of these patients suffered severe adverse effects. Conclusions: Mometasone furoate microemulsion is a safe and effective therapy in the treatment of symptomatic erosive‐ulcerative OLP.

Mometasone furoate

Erythema

Oral Lichen Planus

Clinical efficacy

10.1111/j.1600-0714.2004.00213.x

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Citations (32)