R A Zajac

Wilford Hall Medical Center

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R. N. Boswell

Middlemore Hospital

Mario Clerici

University of Milan

G M Shearer

National Institutes of Health

Daniel R. Lucey

Dartmouth College

E Malatinský

Detská Fakultná Nemocnica s Poliklinikou

G. P. Melcher

University of California, San Francisco

Jay A. Berzofsky

National Institutes of Health

N I Stocks

National Institutes of Health

Gilbert Reibnegger

Medical University of Graz

Dietmar Fuchs

Innsbruck Medical University

Cooperative Institutions

National Institutes of Health

National Cancer Institute

Wilford Hall Medical Center

Comenius University Bratislava

University Hospital Bratislava

University of Maryland, Baltimore

Innsbruck Medical University

Texas Biomedical Research Institute

Joint Base San Antonio

Kirtland Air Force Base

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Treatment of Listeria Bacteremia with Vancomycin

Clinical Infectious Diseases (1990)

Stephen P. Blatt R A Zajac

Journal Article Treatment of Listeria Bacteremia with Vancomycin Get access Stephen P. Blatt, Stephen P. Blatt Infectious Disease Service, Department of Medicine. Wilford Hall U.S. Air Force Medical Center. Lackland Air Force Base, Texas Reprints and correspondence: Dr. Stephen P. Blatt, Captain, USAF, MC, Wilsord Hall USAF Medical CenterISGHMMI, Lackland AFB, Texas 78236-5300. Search for other works by this author on: Oxford Academic PubMed Google Scholar Robert A. Zajac Robert A. Zajac Infectious Disease Service, Department of Medicine. Wilford Hall U.S. Air Force Medical Center. Lackland Air Force Base, Texas Search for other works by this author on: Oxford Academic PubMed Google Scholar Reviews of Infectious Diseases, Volume 13, Issue 1, January 1991, Pages 181–182, https://doi.org/10.1093/clinids/12.5.181 Published: 01 January 1990

Bacteremia

10.1093/clinids/12.5.181

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Citations (26)

Spectrum of Cerebrospinal Fluid Findings in Various Stages of Human Immunodeficiency Virus Infection

Archives of Neurology (1988)

D. W. Marshall Robin L. Brey William T. Cahill Richard W. Houk R A Zajac

This report summarizes the results of neurologic and cerebrospinal fluid (CSF) study findings in over 400 of the 649 human immunodeficiency virus-infected US Air Force personnel, evaluated as of Dec 31, 1987. Eighty percent of these patients were entirely asymptomatic and immunologically normal, 13% had low T-helper lymphocyte counts and/or cutaneous anergy, and only 7% had opportunistic infection. Sixty-three percent of all patients had some CSF abnormality. Sixty percent of the asymptomatic group had at least one abnormal result, over 25% had three or four CSF abnormalities, and over 7% had five or six abnormal values. When patients with evidence of blood-brain barrier leak were excluded, significant differences were seen between disease groups with regard to CSF glucose, CSF IgG levels, and CSF IgG synthesis. No human immunodeficiency virus-related central nervous system abnormalities were found on neurologic examination in immunologically intact asymptomatic patients regardless of CSF findings. No clear-cut predictor of impending central nervous system complications has, as yet, been identified from the CSF parameters studied.

10.1001/archneur.1988.00520330032007

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Citations (171)

Sequential acute gastroenteritis from contaminated drinking water caused by norwalk virus and cryptosporidium

D apos Antonio Rosato Richard E. Winn R A Zajac

Norwalk virus

Contaminated water

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Citations (1)

[Hemodynamic changes in varicoceles and their relation to fertility].

PubMed (1990)

E Malatinský R A Zajac P. Lepieš

Hemodynamic changes in the vascular bed of the affected testis were studied in 45 sterile and 6 fertile patients with varicocele. The examination method used was modified abdominal angiography. The most frequently recorded change in the arterial bed was persistence of the contrast medium in the left internal testicular artery (5 patients). All these patients were from the group of sterile subjects. The most frequent finding in the venous bed was venous reflux from the left renal vein into the left internal testicular vein (45 sterile and 2 fertile patients). In some sterile patients pathologic opening or origin of the vessels was observed. The substantially higher rate of hemodynamic changes in sterile patients suggests their direct relationship to spermiogenesis.

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Hepatitis C Antibody in a Non-Hemophiliac Cohort Infected with the Human Immunodeficiency Virus

Viral Immunology (1990)

Daniel R. Lucey Craig W. Hendrix Chester Andrzejewski David L. McGlasson William W. Ward

Development of a serologic test which detects antibody to hepatitis C virus (anti-HCV) allowed us to compare the seroprevalence of hepatitis C and hepatitis B in 493 persons infected with the human immunodeficiency virus (HIV). These persons, none of whom are hemophiliacs, are part of the US Air Force HIV Natural History Study. We found that Hepatitis B core antibody (anti-HBc) was far more prevalent (59%) than anti-HCV (8%). Anti-HBc prevalence was not different between those with and those without anti-HCV, being present in the majority of persons in both groups. In addition, we compared anti-HCV+ and anti-HCV negative persons in terms of syphilis serologiec (Reactive Plasma Reagent [RPR] and Fluorescent Treponemal Antibody Absorption [FTA-ABS]), hepatic transaminase levels, and racial composition. In this cohort, we found that anti-HCV+ persons are significantly more likely to have a positive RPR but not FTA-ABS, increased hepatic transaminase levels, and to be Black rather than Caucasian.

Seroprevalence

Hepatitis C

10.1089/vim.1990.3.295

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Citations (3)

X-ray findings on the testicular artery in varicocele

International Urology and Nephrology (1988)

E Malatinský R A Zajac J. Bilický Vladimír Šámal

Testicular artery

Aortography

10.1007/bf02549516

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Citations (1)

Congenital anomalies of the seminal ducts

International Urology and Nephrology (1987)

E Malatinský F. Lábady P. Lepieš R A Zajac Marián Jančár

Utricle

Nephrology

Ejaculatory duct

Vas deferens

10.1007/bf02550472

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Citations (11)

Activated cell-mediated immunity and reduced proliferative response of T-cells in vitro in patients with HIV-1 infection

Clinical & Experimental Immunology (1990)

Dietmar Fuchs G M Shearer R. N. Boswell Mario Clerici Gilbert Reibnegger

Cell mediated immunity

Cellular immunity

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Common epitope in human immunodeficiency virus (HIV) I-GP41 and HLA class II elicits immunosuppressive autoantibodies capable of contributing to immune dysfunction in HIV I infected individuals.

PubMed (1990)

Hana Golding G M Shearer Kathleen Hillman Pilar Lucas Jody Manischewitz

We previously reported the identification of highly conserved homologous regions located in the carboxy terminus of the HIV I gp41-envelope (aa 837-844), and the amino-terminal of the beta chain of all human HLA class II antigens (aa 19-25). Murine monoclonal antibodies, raised against synthetic peptides from these homologous regions, bound not only to the isolated peptides, but also to the native gp160 and class II molecules. In this study one-third of sera from HIV I-infected individuals, at different disease stages, were found to react with both the gp41 and class II-derived peptides. These sera also reacted with "native" HLA class II molecules. The potential affects of such autoantibodies on normal immune functions were examined. It was found that in the presence of class II-cross-reactive (but not control) sera, the proliferative responses of normal CD4+ T cells to tetanus toxoid and allogeneic stimuli were markedly decreased. In addition, these sera could eliminate class II-bearing cells by antibody dependent cellular cytotoxicity. Similar affects were seen with affinity-purified IgG antibodies from patients' sera. Thus, the "molecular mimicry" between HIV I and HLA class II antigens, may lead to the generation of autoantibodies in HIV I-infected individuals that may contribute to the early functional impairment of CD4+ T cell observed in many HIV I-infected individuals.

Toxoid

Molecular mimicry

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Citations (197)

Multideterminant regions of the HIV-1 envelope with sites seen by murine and human helper T cells: circumventing the MHC restriction problem

Jay A. Berzofsky P Hale Mario Clerici Kemp B. Cease R A Houghten

Envelope (radar)

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