OBJETIVE: Primary extragonadal germ cell tumors are rare and their histogenetic origin is not clear.We describe two cases presenting as primary retroperitoneal germ cell tumors without clinical evidence of testicular tumor.METHODS: A 21 and 18 years-old patients presented retroperitoneal choriocarcinoma and yolk sac tumor, respectively.In both cases, testicular palpation was not suspicious for testicular cancer.Testicular ultrasound founded alterations in right testes.RESULTS: A right orchitectomy were performed and the final diagnostics were mature teraroma associated with intratubular malignant germ cell.Resumen.-OBJETIVO: Los tumores primarios de células germinales extragonadales son poco frecuentes y su origen histogenético no está claro.Describimos dos casos que se presentaron como tumores de células germinales retroperitoneales sin evidencia clínica de tumor testicular. MÉTODOS: Dos pacientes de 21 y 18 años presentaron respectivamente un coriocarcinoma y un tumor del saco embrionario retroperitoneales. En ambos casos, la palpación testicular no era sospechosa de cárcel testicular. La ecografía testicular descubrió alteraciones en los testículos derechos de ambos pacientes.RESULTADOS: Se llevó a cabo orquiectomía derecha con el diagnóstico final de teratoma maduro asociado con células germinales malignas intratubulares.CONCLUSIONES: El teratoma maduro del adulto es poco frecuente, y los tumores de células germinales retroperitoneales deben ser consideradas metástasis de un cáncer testicular fundido.
OBJETIVE: We describe the clinical, histological and immunohistochemical studies in a case of extramammary Paget´s disease localized in the scrotum with lymph node inguinal metastasis.METHODS/RESULTS: A 80-year old man consulted with a one-year history of a pruritic erythematous skin rash of the scrotum.Physical examination showed demarcated erythematous lesion involving the scrotum and right inguinal adenopathy.Final histological examination revealed extramammary Paget´s disease with inguinal metastasis.CONCLUSION: Extramammary Paget´s disease of the scrotum is a rare disease.This pathological conditionResumen.-OBJETIVO: Describimos los estudios clínicos, histológicos e inmunohistoquímicos en un caso de enfermedad de Paget extramamaria localizada en el escroto con metástasis a los ganglios linfáticos inguinales.METODOS/RESULTADOS: Una paciente de 80 años de edad consultó por una lesión eritematosa pruriginosa del escroto de un año de evolución.El examen físico mostró una lesión eritematosa demarcada que involucraba el escroto y adenopatía inguinal derecha.El exámen histológico final demostró enfermedad de Paget extramamaria con metástasis inguinal.CONCLUSION: La enfermedad de Paget extramamaria del escroto es una rara entidad.Esta condición patológica puede invadir la región dérmica y los ganglios linfáticos inguinales.Aunque neoplasias genitourinarias pueden acompañar la enfermedad de Paget exramamaria, una búsqueda extensa para cáncer puede ser innecesaria.
We report herein the clinical, histological, and immunohistochemical features of a case of sarcomatoid chromophobe renal cell carcinoma.A 59-year-old woman referred a two-month history of constant right flank pain, and hematuria. A right radical nephrectomy was performed. Gross pathologic examination showed a tumor located in the lower part of the kidney with two different aspects. Histologically, the tumor was composed of two intermixed distinct morphologic components: a chromophobe renal cell carcinoma and a high-grade spindle cell sarcoma.Our case represent a typical sarcomatoid chromophobe cell carcinoma. This unusual renal cancer has the potential to behave aggressively and to metastasize.
It is now possible to reduce a man's risk of developing biopsy-detectable prostate cancer. This review addresses the evidence and issues surrounding prostate cancer risk reduction.The scientific basis, therapeutic approach, and risks and benefits of prostate cancer prevention are reviewed. Special attention is given to data on 5α-reductase inhibitors (5-ARIs).Medline searches consisted of articles published since 2003 regarding prostate cancer chemoprevention, prevention, or risk reduction, as well as searches around specific topics within this review.Current data support the use of finasteride for prostate cancer risk reduction in appropriately selected men. The initial concern that finasteride increased the incidence of high-grade prostate cancer has not been confirmed by subsequent analyses. The efficacy of dutasteride, a dual 5-ARI, for prostate cancer risk reduction is currently being evaluated in men with elevated prostate-specific antigen (PSA). Other medical approaches to prostate cancer risk reduction, including statins, cyclooxygenase-2 (COX-2) inhibitors, selective estrogen receptor modulators, and dietary supplements, await validation in controlled clinical trials.It is now possible to reduce an individual man's risk of developing biopsy-detectable prostate cancer. The greatest benefit arises from decreasing the amount of unnecessary treatment in men harboring low-risk cancers. Presently, there is no evidence that 5-ARIs or any other approach to prostate cancer risk reduction will reduce the risk of lethal prostate cancers. Finasteride, however, does enhance the utility of PSA for diagnosing high-grade cancers.
Cellular pseudosarcomatous fibroepithelial stromal polyp is an underrecognized lesion described in the lower female genital tract. We here report the clinical, histological, and immunohistochemical features of a cellular pseudosarcomatous fibroepithelial stromal polyp located in the renal pelvis. A 47‐year‐old woman was referred with a 4‐month history of left flank pain and gross hematuria. Left radical nephrectomy was performed. Gross pathological examination showed irregular pedunculated polypoid masses that had developed from the renal pelvis. Histologically, spindle cells with a patternless appearance were seen. The cells were of different sizes and had discernible cytoplasmic bipolar processes. Atypical stromal cells and atypical mitoses were also found. This case represents a typical cellular pseudosarcomatous fibroepithelial stromal polyp, probably developing from a reactive hyperplastic process involving the subepithelial stroma.