Bahareh Mohebbi

Tehran University of Medical Sciences

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Sara Assadiasl

Tehran University of Medical Sciences

Maryam Sadr

Tehran University of Medical Sciences

Narjes Soleimanifar

Tehran University of Medical Sciences

Mohammad Hossein Nicknam

Tehran University of Medical Sciences

Nima Rezaei

Children's Medical Center

Banafsheh Mosharmovahed

University of Tehran

Bita Ansaripour

Tehran University of Medical Sciences

Mahboobeh Freidoon

Shahid Beheshti University of Medical Sciences

Yousef Fatahi

Tehran University of Medical Sciences

Farzaneh Sadat Minoo

University of Tehran

Cooperative Institutions

Tehran University of Medical Sciences

University of Tehran

Shahid Beheshti University of Medical Sciences

Imam Khomeini Hospital

Children's Medical Center

Universal Scientific Education and Research Network

Iran University of Medical Sciences

Shahid Beheshti University

Shariati Hospital

Tarbiat Modares University

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Aberrant DNA methylation of the promoters of JAK2 and SOCS3 in juvenile systemic lupus erythematosus

European Cytokine Network (2021)

Mahsa Keshavarz‐Fathi Golshid Sanati Maryam Sadr Bahareh Mohebbi Vahid Ziaee

10.1684/ecn.2021.0469

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Citations (4)

DNA Methylation of CD70 Promoter in Juvenile Systemic Lupus Erythematosus

Fetal and Pediatric Pathology (2020)

Mahsa Keshavarz‐Fathi Golshid Sanati Maryam Sadr Bahareh Mohebbi Vahid Ziaee

Epigenetic alterations in pathogenesis of systemic lupus erythematosus (SLE) have gained more attention recently in adults. We assessed the methylation of CD70 promoter, a costimulatory molecule on T cells, in juvenile SLE (JSLE), and compared this to that found in controls and the literature of adult SLE patients.DNA methylation status was evaluated on peripheral blood from JSLE patients and healthy controls.Twenty-five patients with JSLE and 24 healthy controls were compared. JSLE patients had lower unmethylated CpG islands compared to the control group (mean ± SD; 0.78 ± 0.42 vs 10503.80 ± 39796.95). However, the difference was not significant (P-value; 0.22).Despite hypomethylation of CD70 gene promoter in CD4+ T-cells from adult patients with SLE, no statistically significant differences observed in patients with JSLE compared with healthy controls. This may suggest a mechanism different in JSLE patients than in adults.

CpG site

Pathogenesis

10.1080/15513815.2020.1764681

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Citations (9)

Comparing IRF-4 Gene Expression Between Acute T cell- Mediated Rejection and Stable Renal Transplant Recipients.

PubMed (2021)

Mahboobeh Freidoon Fatemeh Pour-Reza-Gholi Azam Alamdari Farzaneh Sadat Minoo Narjes Soleimanifar

Renal transplant rejection is one of the clinical challenges, which usually requires administration of immunosuppressive drugs causing serious side effects. Therefore, invention of effective and specific therapeutics is necessary to control undesired immune responses particularly T-cell reactions to allograft. Interferon Regulatory Factor-4 (IRF-4) due to its implication on T cells differentiation and function might be targeted to treat T cell-mediated cellular rejection (TCMR). The aim of this study was to investigate the association between IRF-4 gene expression and acute TCMR, as well as to examine the correlation between IRF-4 gene expression and cellular expression of Programmed cell death-1 (PD-1) and Helios molecules.Peripheral blood samples were obtained from 30 patients with biopsy proven acute TCMR and 30 stable recipients. IRF-4 gene expression was quantified using RT-PCR, and cellular expression of PD-1 and Helios were evaluated with flowcytometry.IRF-4 gene expression was significantly increased in acute TCMR patients compared with stable recipients (P < .05). Helios protein expression was slightly decreased in TCMR group but this was not statistically significant. There was a negative correlation between IRF-4 gene expression and PD-1 as well as Helios frequency in the whole studied population.IRF-4 expression increases in acute TCMR which might also lead to a diminished expression of downstream immunoregulatory molecules such as PD-1 and Helios. Therefore, specific inhibition of IRF-4 may be helpful in managing acute TCMR.

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Th17/Treg cell balance in stable liver transplant recipients

Transplant Immunology (2022)

Sara Assadiasl Mohsen Nassiri Toosi Bahareh Mohebbi Bita Ansaripour Narjes Soleimanifar

Liver function

10.1016/j.trim.2022.101540

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Citations (10)

Association of ADAM33 T1 Polymorphism With Subgroups of Pediatric Asthma Patients in Iran

ACTA MEDICA IRANICA (2020)

Mir Reza Ghaemi Sara Hemmati Arezou Rezaei Maryam Sadr Bahareh Mohebbi

There is strong evidence on the interaction of several genetic variations and environmental conditions in the etiology of asthma. Association of a disintegrin and metalloproteinase 33 (ADAM33) with asthma risk is not clear and shows diversity between nations and ethnicities. Several single nucleotide polymorphisms (SNP) of the ADAM33 gene are introduced and studied according to the disease onset and characteristics. The aim of our study is to determine the association of ADAM33 rs2280091 polymorphism and pediatric asthma in the Iranian population. A total of 63 asthma patients (aged 6-18) and 86 healthy controls were enrolled in our study. Asthma type, classification, and severity were defined. SNPs of the ADAM33 gene at rs2280091 (T1) were analyzed. Pulmonary function tests, total blood eosinophil count, and IgE count were also assessed. T1 genotype and allele frequencies were not associated with asthma risk in Iranian pediatric asthma. Atopic asthma subgroup and patients with normal eosinophil count showed association with ADAM33 rs2280091. Moreover, asthma patients with AG genotype showed lower pulmonary functions.

Etiology

SNP

10.18502/acta.v57i11.3259

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Citations (1)

Baricitinib: From Rheumatoid Arthritis to COVID‐19

The Journal of Clinical Pharmacology (2021)

Sara Assadiasl Yousef Fatahi Banafsheh Mosharmovahed Bahareh Mohebbi Mohammad Hossein Nicknam

Baricitinib is a JAK1/2 inhibitor that was first approved for treating moderate to severe rheumatoid arthritis (RA) but that later showed considerable efficacy in the control of exaggerated inflammatory responses that occur in a wide range of diseases. There is a growing body of evidence, obtained from clinical trials and case reports, demonstrating clinical and paraclinical improvement in patients following administration of baricitinib including RA, systemic lupus erythematosus, psoriasis, atopic dermatitis, alopecia areata, interferon-mediated autoinflammatory diseases, graft-versus-host disease, diabetic kidney disease, and, recently, coronavirus disease-19. However, despite overall encouraging results, many adverse effects have been observed in baricitinib-treated patients, ranging from simple infections to increased risk of malignancies, particularly in long-term use. The significant efficacy of baricitinib, versus the probable adverse effects, urge further investigation before establishing it as a part of standard therapeutic protocols. Here, we have provided a review of the studies that have used baricitinib for treating various inflammatory disorders and summarized the advantages and disadvantages of its administration.

10.1002/jcph.1874

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Citations (54)

B Lymphocyte Subset Changes in Primary Membranous Nephropathy

Nephro-Urology Monthly (2019)

Katayoun Hasanzadeh Fatemeh Pour-Reza-Gholi Narjes Soleimanifar Nooshin Dalili Mahboobeh Freidoon

Background: Primary membranous nephropathy (PMN) is an autoimmune disease affecting renal glomerulus, characterized by autoantibodies aggregation on podocytes and subsequent epithelial thickening. Therefore, rituximab, an anti-CD20 monoclonal antibody, is used to treat patients with the deteriorating condition. Objectives: Assuming that rituximab demolishes a considerable number of B-lymphocytes and causes transient immunodeficiency, we aimed to identify B cell subsets involved in PMN pathogenesis to facilitate specific targeting. Methods: Using flowcytometery, 25 PMN patients including 15 on standard treatment and 10 on standard treatment plus rituximab were enrolled to compare with healthy controls. Rituximab-receiving patients were studied before and two months after administration. Results: Neither total CD19+ nor memory B cell percentages showed significant differences between the study groups. However, the number of B regulatory cells (Breg) was lower in both standard-treatment and Rituximab-receiving patients than in controls. Moreover, the percentage of naïve/mature B cells dropped after standard treatment. Conclusions: PMN patients seem to possess an insufficient percentage of Breg cells, which are involved in immunomodulation. Furthermore, the standard-treatment group showed a reduced count of naïve/mature B cells, which constitute a substantial proportion of normal B lymphocytes population.

Membranous Nephropathy

10.5812/numonthly.96425

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Tocilizumab in transplantation

European Journal of Clinical Pharmacology (2020)

Banafsheh Mosharmovahed Yousef Fatahi Bahareh Mohebbi Sohrab Ali Ghorbanian Sara Assadiasl

Tocilizumab

10.1007/s00228-020-02864-6

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Citations (12)

Evaluation of ABCB1 Gene Promoter Methylation in Patients with Ulcerative Colitis

Immunology and Genetics Journal (2024)

Hossein Sanjari Moghaddam Golshid Sanati Maryam Sadr Bahareh Mohebbi Mahsa Keshavarz-Fathi

Background: The pathogenesis of inflammatory bowel disease may be associated with the disruption in interactions between the immune system and gut flora. Epigenetic mechanisms especially, DNA methylation appear to be significant regarding the interaction between the environment and genome. ABCB1 is the encoding gene for multi-drug resistance protein 1 (MDR1) (P-glycoprotein), which is an important transmembrane protein responsible for the efflux of cellular molecules from the intestinal wall to the lumen Method: In this study, we compared the methylation status of the promoter of ABCB1 in rectal mucosa of patients with ulcerative colitis (UC) and healthy controls by using the bisulfite conversion system and realtime quantitative multiplex methylation-specific PCR (QM-MSP). Results: We demonstrated that the mucosal specimen of 26 UC patients had significantly higher levels of promoter methylation in comparison to 26 controls. Conclusion: As the first investigation of Iranian patients with UC, we showed that patients had higher levels of ABCB1 promoter methylation in their inflammatory rectal mucosa compared to controls. However, this altered state of methylation did not associate with the characteristics of the patients such as age and sex. Our findings are a basis for further studies on concurrent assessment of promoter methylation and expression of ABCB1 in UC.

Pathogenesis

Bisulfite sequencing

10.18502/igj.v6i1.16340

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Association of PTPN22 single nucleotide polymorphisms with chronic spontaneous urticaria

Allergologia et Immunopathologia (2021)

Maryam Sadr Neda Khalili Bahareh Mohebbi Banafsheh Mosharmovahed Parivash Afradi

Introduction and objectives: Chronic spontaneous urticaria (CSU) is thought to be an auto-immune disease in a subpopulation of patients. Protein tyrosine phosphatase-22 (PTPN22) polymorphisms are considered to be one of the strongest contributing factors to autoimmune diseases. In this study, we aimed to investigate the potential association of several PTPN22 single nucleotide polymorphisms (SNPs) with CSU in an Iranian population.Material and methods: A total of 93 CSU patients and 100 healthy individuals were included in this study. Five SNPs within the PTPN22 gene were analyzed using TaqMan genotyping assays. The frequency of alleles, genotypes, and haplotypes of PTPN22 SNPs (rs12760457, rs2476601, rs1310182, rs1217414, and rs33996649) was investigated.Results: A significantly higher prevalence of the rs1310182 T allele was observed among patients compared with controls [OR = 1.75 (95% CI: 1.17–2.63); P = 0.007]. In addition, the rs1310182 CC genotype and TT genotype were 0.47 and 2.06 times more common in patients, respectively (P = 0.03). Moreover, haplotype analysis demonstrated that CGCGC, CGTGC, and TGCGC (P < 0.001) were significantly associated with CSU. No significant differences were observed between the patients and controls in the other analyzed PTPN22 SNPs.Conclusions: Polymorphisms of the PTPN22 gene are associated with an increased susceptibility to CSU in the studied Iranian population.

PTPN22

TaqMan

10.15586/aei.v49i2.53

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Citations (5)