Hossein Montazerian

Center for Special Minimally Invasive and Robotic Surgery

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Ali Khademhosseini

University of California, Los Angeles

Elham Davoodi

University of California, Los Angeles

Reihaneh Haghniaz

Terasaki Foundation

Abbas S. Milani

University of British Columbia

Paul S. Weiss

University of California, Los Angeles

Nasim Annabi

University of California, Los Angeles

Javad Kadkhodapour

Shahid Rajaee Teacher Training University

Avijit Baidya

University of California, Los Angeles

Han‐Jun Kim

Terasaki Foundation

Mina Hoorfar

University of Victoria

Cooperative Institutions

University of California, Los Angeles

Terasaki Foundation

California NanoSystems Institute

Center for Special Minimally Invasive and Robotic Surgery

Samueli Institute

University of British Columbia

University of Sydney

Brigham and Women's Hospital

Sharif University of Technology

Okanagan University College

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3D printed flexible wearable sensors based on triply periodic minimal surface structures for biomonitoring applications

Smart Materials and Structures (2022)

Mohammad Ebrahim Imanian Mostafa Kardan-Halvaei Fatemeh Nasrollahi A. Imanian Hossein Montazerian

Abstract Soft piezoresistive wearable conductors have led to a paradigm shift in the monitoring of human bodily motions. Cellular additively manufactured conductors are promising piezoresistive components as they offer mechanical tunability and provide controllable percolation pathways. In the present study, we engineer high surface-area cellular structures with the triply periodic minimal surface (TPMS)-based architectures to tailor their piezoresistive response for use in wearable devices. A simple and economical fabrication process is proposed, wherein a fused deposition modeling 3D printing technique is utilized to fabricate flexible thermoplastic polyurethane (TPU) cellular structures. Interconnectivity of TPMS designs enables the coating of a continuous graphene layer over the TPU internal surfaces via a facile dip-coating process. The effects of pore shape on piezoresistivity are studied in four different TPMS structures (i.e. Primitive, Diamond, Gyroid, and I-WP). Mechanical properties of sensors are evaluated through experimental procedures and computation methods using finite element analysis of the Mooney–Rivlin hyperelastic model. The piezoresistive performance of sensors exhibits durability under cyclic compression loading. Finally, we conclude that the Primitive structure offers suitable piezoresistive characteristics for sensing of walking, whereas the Diamond structure presents favorable results for respiration monitoring.

Piezoresistive effect

Thermoplastic polyurethane

Interconnectivity

10.1088/1361-665x/aca6bc

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Citations (11)

An All‐In‐One Transient Theranostic Platform for Intelligent Management of Hemorrhage (Adv. Sci. 24/2023)

Advanced Science (2023)

Reihaneh Haghniaz Ankit Gangrade Hossein Montazerian Fahimeh Zarei Menekşe Ermis

Theranostic Devices In article number 2301406 by Reihaneh Haghniaz, Ali Khademhosseini, Yangzhi Zhu, and co-workers, an all-in-one theranostic platform is presented that is constructed by sandwiching a highly porous silk sponge between two silver nanowire-based conductive electrodes to non-enzymatically diagnose local bleeding and stop the hemorrhage at the wound site. Such a platform provides an unexplored strategy for intelligent hemorrhage management and post-operative infection control.

Transient (computer programming)

10.1002/advs.202370158

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Injectable gelatin-oligo-catechol conjugates for tough thermosensitive bioadhesion

Cell Reports Physical Science (2023)

Hossein Montazerian Elham Davoodi Alireza Hassani Najafabadi Reihaneh Haghniaz Avijit Baidya

Extracellular matrix-derived biomaterials, such as gelatin-based hydrogels, are attractive candidates for sealing internal leakages. However, gelatin derivatives are brittle and suffer from poor adhesion. Modifications of gelatin with adhesive catechol moieties have been limited to low degrees of substitution. Here, we propose oxidative oligomerization of catecholic compounds (namely, caffeic acid [CA]) prior to the coupling reaction to augment the number and availability of grafted catechol groups per carbodiimide conjugation reaction, thereby achieving robust bioadhesion. Ex vivo adhesion tests on pig lungs suggests ∼3× improvement in adhesion strength compared with gelatin methacryloyl controls due to their enhanced cohesion (i.e., ∼5.3× and ∼11.5× improvements in stretchability and toughness, respectively). Functionalization of gelatin with CA oligomers enables rapid formation of physical gels upon exposure to room temperature, tunes the viscosity of the gelatin-caffeic acid pre-gel solution for controllable injectability onto multiply curved tissues, and boosts the antioxidant effects of CA.

Gelatin

Catechol

Surface Modification

Viscosupplementation

10.1016/j.xcrp.2023.101259

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Citations (12)

Contributors

Elsevier eBooks (2023)

Nesma T. Aboulkhair Stefan Becker M Benoit Federico Bosio Piotr Breitkopf

10.1016/b978-0-323-88664-2.09990-5

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Fluid Permeability of Graded Porosity Scaffolds Architectured with Minimal Surfaces

ACS Biomaterials Science & Engineering (2019)

Masoud Zhianmanesh Mostafa Varmazyar Hossein Montazerian

The natural local porosity variation in the native tissue can be replicated by graded porosity scaffolds. Scaffolds with radial porosity distribution can be a solution to improve both mechanical and biological functions of the biomimetic scaffolds. In the present study, fluid permeability as a quantitative indicator of biological performance is studied numerically and experimentally for different pore shapes and porosity distribution patterns in the scaffolds designed on the basis of triply periodic minimal surfaces (TPMSs). Among the uniform porosity scaffolds, those designed on the basis of P* (P surface) and Y** (G surface) showed the highest permeability. In the radially graded porosity scaffolds with linear porosity distribution, permeability was found to be about twice more sensitive to the peripheral porosity than the porosity at the center. The results suggest that the permeability-gradient parameter relationships can follow different trends depending on the pore shape as opposed to the conventional uniform porosity scaffolds. This implies the need for the design maps that were developed to choose appropriate scaffold pore design parameters. Finally, experimental permeability measurement was performed via a constant head permeability test, and the effect of test parameters (i.e., fluid height) was discussed.

10.1021/acsbiomaterials.8b01400

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Citations (77)

The relationships between deformation mechanisms and mechanical properties of additively manufactured porous biomaterials

Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials (2016)

Javad Kadkhodapour Hossein Montazerian Ali Darabi A. Zargarian Siegfried Schmauder

Shearing (physics)

Deformation mechanism

10.1016/j.jmbbm.2016.09.018

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Citations (89)

Hybrid Nanosystems for Biomedical Applications

ACS Nano (2021)

Joshua Seaberg Hossein Montazerian Md. Nazir Hossen Resham Bhattacharya Ali Khademhosseini

Inorganic/organic hybrid nanosystems have been increasingly developed for their versatility and efficacy at overcoming obstacles not readily surmounted by nonhybridized counterparts. Currently, hybrid nanosystems are implemented for gene therapy, drug delivery, and phototherapy in addition to tissue regeneration, vaccines, antibacterials, biomolecule detection, imaging probes, and theranostics. Though diverse, these nanosystems can be classified according to foundational inorganic/organic components, accessory moieties, and architecture of hybridization. Within this Review, we begin by providing a historical context for the development of biomedical hybrid nanosystems before describing the properties, synthesis, and characterization of their component building blocks. Afterward, we introduce the architectures of hybridization and highlight recent biomedical nanosystem developments by area of application, emphasizing hybrids of distinctive utility and innovation. Finally, we draw attention to ongoing clinical trials before recapping our discussion of hybrid nanosystems and providing a perspective on the future of the field.

10.1021/acsnano.0c09382

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Citations (139)

Dielectrophoretic manipulation of particles on a microfluidics platform with planar tilted electrodes

Sensors and Actuators B Chemical (2020)

Arash Dalili Hossein Montazerian Kabilan Sakthivel Nishat Tasnim Mina Hoorfar

Dielectrophoresis

Polystyrene

Microchannel

Particle (ecology)

10.1016/j.snb.2020.129204

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