Josef Cvačka

Research Field

Herein, we report the use of the Suzuki-Miyaura cross-coupling reaction for the preparation of a library of synthetic derivatives of flavonoids for biological activity assays. We have investigated the reactivity of halogenated flavonoids with aryl boronates and with boronyl flavonoids. This reaction was used to prepare new synthetic derivatives of flavonoids substituted at C-8 with aryl, heteroaryl, alkyl, and boronate substituents. The formation of flavonoid boronate enabled a cross-coupling reaction with halogenated flavones yielding biflavonoids connected at C-8. This method was used for the preparation of natural compounds including C-8 prenylated compounds, such as sinoflavonoid NB. Flavonoid boronates were used for the preparation of rare C-8 hydroxyflavonoids (natural flavonoids gossypetin and hypolaetin). A series of previously unknown derivatives of quercetin and luteolin were prepared and fully characterized.

Suzuki reaction

Coupling reaction

Flavones

Biflavonoids

10.3390/molecules27030967

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Citations (11)

Identification by GC-EAD of the two-component trail-following pheromone of Prorhinotermes simplex (Isoptera, Rhinotermitidae, Prorhinotermitinae)

Journal of Insect Physiology (2009)

David Sillam‐Dussès Blanka Kalinová Pavel Jiroš Anna Březinová Josef Cvačka

10.1016/j.jinsphys.2009.04.007

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Citations (37)

New peptides with antimicrobial activity isolated from the venom of the bumblebee Bombus pascuorum (hymenoptera: apidae)

Rudolf Ježek Daniela Janechová Josef Cvačka Jiřina Slaninová Zdeněk Vobůrka

Bumblebee

10.1135/css200911051

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A comparison of HPLC/APCI-MS and MALDI-MS for characterising triacylglycerols in insects: Species-specific composition of lipids in the fat bodies of bumblebee males

Journal of Chromatography B (2009)

Edita Kofroňová Josef Cvačka Vladimír Vrkoslav Robert Hanus Pavel Jiroš

Bumblebee

Atmospheric-pressure chemical ionization

Bombus terrestris

10.1016/j.jchromb.2009.09.040

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Citations (24)

Electrochemical reduction of azidophenyl-deoxynucleoside conjugates at mercury surface

Electrochimica Acta (2017)

Aleš Daňhel Zuzana Trošanová Jana Balintová Anna Šimonová Lubomı́r Pospı́šil

Bulk electrolysis

Supporting electrolyte

Polarography

Electrosynthesis

10.1016/j.electacta.2017.10.128

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Citations (6)

MALDI Mass Spectrometry Imaging of Lipids on Free-Floating Brain Sections and Immunohistochemically Colocalized Markers of Neurodegeneration

Methods in molecular biology (2021)

Štěpán Strnad Veronika Strnadová David Sýkora Josef Cvačka Lenka Maletı́nská

Paraformaldehyde

Mass spectrometry imaging

10.1007/978-1-0716-2030-4_16

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Citations (3)

CCDC 2221719: Experimental Crystal Structure Determination

The Cambridge Structural Database (2023)

Doroteja Lončarić Fahimeh Movahedifar Jakub Radek Štoček Martin Dračínský Josef Cvačka

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

10.5517/ccdc.csd.cc2dkwc7

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Citations (0)

Analgesic compounds from Scorzonera latifolia (Fisch. and Mey.) DC.

Journal of Ethnopharmacology (2010)

Özlem Bahadır Gülçin Saltan Çitoğlu Karel Šmejkal Stefano Dall’Acqua Hanefi Özbek

Folk medicine

10.1016/j.jep.2010.06.003

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Citations (33)

Transition metal complexes bearing NHC ligands substituted with secondary polyfluoroalkyl groups

Dalton Transactions (2015)

Viola Kolaříková Ondřej Šimůnek Markéta Rybáčková Josef Cvačka Anna Březinová

Silver and palladium complexes bearing dihydroimidazolylidene or imidazolidinylidene NHC ligands substituted with racemic secondary polyfluoroalkyl groups were synthesized.

10.1039/c5dt02258d

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Citations (11)

Galectin-targeting glycocalix[4]arenes can enter the cells

Chemical Communications (2023)

Miluše Vlachová V.N. Tran Jakub Červený František Dolníček Lucie Petrásková

Elevated levels of galectin-3 are associated with tumorigenesis. Its inhibition with high-affinity carbohydrate ligands opens new therapeutic routes. Targeting of intracellular galectin-3 is challenging for polar inhibitors like carbohydrates. We demonstrate the potential of novel biomedical research tools, glycocalix[4]arenes, to enter epithelial cells, which may allow their interaction with galectin-3.

Galectin-3

Galectin

Galectin-1

10.1039/d3cc02905k

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Citations (1)

Papers

Citation

H-Index

i-10 index

Papers

Citation

H-Index

i-10 index