TWO topics of current interest in allergy are considered in this study: the present status of histamine, with particular reference to the new antihistaminic drugs; and the role of inhalation therapy, including the aerosols.It would be satisfactory to be able to report that recent advances in allergy have made clear an understanding of the fundamental characteristics of the allergic state. It is true that investigators are gradually learning more about the trigger mechanism that sets off the explosion, but unfortunately they are still ignorant of the nature of the charge with which the allergic gun is loaded. The chief . . .
Article1 November 1955THE USE OF CORTISONE AND HYDROCORTISONE IN ALLERGYWALTER S. BURRAGE, M.D., F.A.C.P., A. C. RITCHIE, M.B., Ch.B., D.Phil., HERBERT C. MANSMANN JR., M.D., JOHN W. IRWIN, M.D., AGNES B. RUSSFIELD, M.D.WALTER S. BURRAGE, M.D., F.A.C.P.Search for more papers by this author, A. C. RITCHIE, M.B., Ch.B., D.Phil.Search for more papers by this author, HERBERT C. MANSMANN JR., M.D.Search for more papers by this author, JOHN W. IRWIN, M.D.Search for more papers by this author, AGNES B. RUSSFIELD, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-43-5-1001 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTIONDuring the last few years compound E (cortisone) and compound F (hydrocortisone) have been used with considerable success to suppress the symptoms of allergic and related disorders. There are those who decry their use, saying that they merely suppress symptoms and that they possess potentially serious side effects. There are also those who seriously misuse these agents, employing them in trivial conditions, often in inadequate dosage and frequently with little or no supervision of the patient. The purpose of this paper is to summarize experiences with cortisone and hydrocortisone in allergic and related disorders during the last four years....Bibliography1. BurrageIrwin WSJW: The role of cortisone in the treatment of severe bronchial asthma, New England J. Med. 248: 679-682, 1953. CrossrefMedlineGoogle Scholar2. SulzbergerWittenSmith MBVHCC: Hydrocortisone (compound F) acetate ointment in dermatological therapy, J. A. M. A. 151: 468-472, 1953. MedlineGoogle Scholar3. Hill LW: Oral cortisone treatment of infantile eczema, New England J. Med. 248: 1051-1056, 1953. CrossrefMedlineGoogle Scholar4. 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LiebowMcFarlandTennant AAWJR: The effects of potassium deficiency on tumor-bearing mice, Yale J. Biol. and Med. 13: 523-538, 1941. MedlineGoogle Scholar38. Bennett WA: Histopathological alterations of adrenal and anterior pituitary glands in patients treated with cortisone, J. Bone and Joint Surg. 36A: 867-874, 1954. CrossrefGoogle Scholar39. WilburRich OMAR: A study of the rôle of adrenocorticotropic hormone (ACTH) in the pathogenesis of tubular degeneration of the adrenals, Bull. Johns Hopkins Hosp. 93: 321-347, 1953. MedlineGoogle Scholar40. GoldenBondySheldon APKWH: Pituitary basophile hyperplasia and Crooke's hyaline change in man after ACTH therapy, Proc. Soc. Exper. Biol. and Med. 74: 455-458, 1950. CrossrefMedlineGoogle Scholar41. O'NealHeinbecker LWP: The adenohypophysis and hypothalamus in hyperadrenalcorticalism, Ann. Surg. 141: 1-9, 1955. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Boston, Massachusetts*Presented as a Morning Lecture at the Thirty-sixth Annual Session of The American College of Physicians, Philadelphia, Pennsylvania, April 27, 1955.From the Medical Service and Department of Pathology, Massachusetts General Hospital, and the Department of Medicine, Harvard University.†Supported by a grant from the Upjohn Company and a grant from the Mary Dexter Fund. The cortisone and part of the hydrocortisone were supplied by Merck and Co., Inc., and part of the hydrocortisone by the Upjohn Company.With the technical assistance of MARY GILCHRIST and PRISCILLA GORDON. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byFatty lesions of both humeri in a patient on corticosteroids and cyclophosphamideAdrenal glucocorticoids after twenty yearsProphylaxis in patients receiving adrenal steroid therapyTHE EFFECTS OF PROLONGED CORTICOSTEROID THERAPYTHE MANAGEMENT OF ALLERGIC DISORDERS WITH ANTI-INFLAMMATORY STEROIDSThe proper use of adrenal hormonal drugs in pediatric practiceThe role of adrenocortical steroids in the treatment of intractable bronchial asthmaSteroid Hormones and the Aging SkeletonAllergy 1 November 1955Volume 43, Issue 5Page: 1001-1018KeywordsAllergy and immunologyHormonesHospital medicineMedical servicesOsteoporosisPeptic ulcersPneumoniaSpineSteroid therapyUrticaria Issue Published: 1 November 1955 PDF downloadLoading ...
THERAPEUTIC advances in allergy have failed to keep pace with the development of antibiotics in the field of infectious disease. Yet it must be remembered that the underlying nature of the allergic state is still imperfectly understood and that control of altered reactivity is a more complicated matter than inactivation of bacteria alone. Progress in allergy has not been dramatic, but it has made forward steps, as shown in part by rapidly expanding interest in the subject both by the medical profession and by the laity. Membership in allergy societies and attendance at medical conferences devoted to allergy have increased . . .
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