Fatemeh Zare

Shiraz University of Medical Sciences

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Mohammad Bayat

Shahid Beheshti University of Medical Sciences

Sufan Chien

University of Louisville

Abdollah Amini

Shahid Beheshti University of Medical Sciences

Mohammad‐Amin Abdollahifar

Shahid Beheshti University of Medical Sciences

Leila Emami

Shiraz University of Medical Sciences

Hossein Sadeghpour

Shiraz University of Medical Sciences

Razieh Sabet

Shiraz University of Medical Sciences

Seyed Kamran Ghoreishi

University of Qom

Samira Feyzi

University of Minnesota

Joyce I. Boye

Agriculture and Agri-Food Canada

Cooperative Institutions

Institute for Health Metrics and Evaluation

451

University of Washington

416

Tehran University of Medical Sciences

180

University College London

122

Shahid Beheshti University of Medical Sciences

114

University of Sydney

Auckland University of Technology

Shiraz University of Medical Sciences

Institute for Musculoskeletal Health

National Health and Medical Research Council

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The Role of Surface Molecules in Host Responses of Leishmaniasis: Focus on Lipid Mediators

Journal of Research in Applied and Basic Medical Sciences (2022)

Ali Fattahi Bafghi Fatemeh Zare Mostafa Gholamrezaei Mahin Ghafourzadeh

Leishmaniasis is a neglected disease that affects more than 12 million people worldwide.After parasite inoculum by female bloodsucking insects, e.g.Phlebotomus, neutrophils quickly infiltrate and phagocytes Leishmania parasites.Macrophages are the second immune cells.They possess several pattern recognition receptors that respond to different surface molecules such as Lipophosphoglycan, glycoprotein 63 (GP63), PPG, GIPL, CP, and SAP.It was found that Leishmania GP63 cleaves several targets of infected macrophages, including the myristoylated alanine-rich C kinase substrate, p130CAS, PEST, NF-B, and AP-1.After activation of surface molecules, lipid metabolites of arachidonic acid, including leukotrienes and prostaglandins, are important mediators in Leishmaniasis.These lipid metabolites can be metabolized by different enzymes, including the cyclooxygenase and lipoxygenase.

Lipophosphoglycan

Leishmania mexicana

10.52547/rabms.8.3.161

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Probiotic Milk Supplementation with Pea Flour: Microbial and Physical Properties

Food and Bioprocess Technology (2012)

Fatemeh Zare Joyce I. Boye Claude P. Champagne Valérie Orsat Benjamin K. Simpson

Syneresis

Bacterial growth

Lactobacillus rhamnosus

10.1007/s11947-012-0828-3

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Citations (25)

Author response for "Surface decoration of low molecular weight polyethylenimine (<scp>LMW PEI</scp>) by phthalated dextrin for improved delivery of interleukin‐12 plasmid"

Valiollah Keshavarz Maryam Kazemi Bahman Khalvati Fatemeh Zare Ali Dehshahri

Polyethylenimine

Dextrin

10.1002/btpr.3443/v2/response1

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LEF1 silencing sensitizes colorectal cancer cells to oxaliplatin, 5-FU, and irinotecan

Biomedicine & Pharmacotherapy (2021)

Elham Fakhr Fatemeh Zare Kayhan Azadmanesh Ladan Teimoori‐Toolabi

Colorectal cancer (CRC) is the third most prevalent cancer all around the world. Chemotherapy plays an essential role in the treatment of CRC while Oxaliplatin, Irinotecan, and 5 – fluorouracil (5-FU) are the most commonly used chemotherapeutic drugs. However, chemo-resistance is a major obstacle to successful therapy. It has been shown that inhibition of Wnt signaling pathway can sensitize the cells to chemotherapy. Lymphoid enhancer factor (LEF1) is a member of TCF/LEF transcription family mediating Wnt nuclear responses. The long isoform of LEF1 is highly expressed in colorectal cancer cells compared to the normal intestinal cells, in which expression of the short isoform is dominant. We found that the downregulation of long isoforms of LEF1 makes CRC cell lines more sensitive to the effect of chemotherapeutic drugs. This sensitivity is imposed by reduced proliferation, increased apoptosis, or cell cycle arrest. Our results also demonstrated that there is a balance in the expression of long, and short isoforms of LEF1. In summary, we showed the role of LEF1 in chemo-resistance of colorectal cancer cells to Oxaliplatin, Irinotecan and 5-FU.

10.1016/j.biopha.2021.112091

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Citations (23)

5-Oxo-dihydropyranopyran derivatives as anti-proliferative agents; synthesis, biological evaluation, molecular docking, MD simulation, DFT, and in-silico pharmacokinetic studies

Heliyon (2024)

Sara Ranjbar Paria Sadeghian Sara Khademian Mina Emami Zahra Pakrouh Jahromi

A series of ethyl 2-amino-7-methyl-5-oxo-4-phenyl-4,5-dihydropyrano[4,3-

Docking (animal)

Molecular model

10.1016/j.heliyon.2024.e29850

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Abstract A19: Silencing LEF1 decreases the resistance of colorectal cancer cell lines to 5-FU as common chemotherapeutic drug

Cancer Research (2017)

Ladan Teimoori‐Toolabi Elham Fakhr Fatemeh Zare

Abstract Wnt signaling pathway is assumed to be the most important pathway activated in colorectal cancer. As this pathway in addition to Notch and hedgehog signaling pathway is responsible for the maintenance of stem cells in the population of cancerous cells, it could be predicted that by silencing this pathway the resistance of cancerous cells to chemotherapeutic drugs would be decreased. In this regard we tried to silence LEF1 as an important component of this pathway in two colorectal cancer cell lines and see the response of transfected cells to 5-flurouracil. Oligonucleotide for silencing LEF1 was constructed and inserted into pSilencer Neo2.1 (Invitrogen). Thereafter these constructed were stably transfected to HCT116 and SW480 as colorectal cancer cell lines after treating the transfected cells with G418 for 21 days. Response of these cells to 5-flurouracil as a common chemotherapeutic drug was studied by MTT proliferation assay. The expression of LEF1 in transfected and non-transfected cells was also studied by Quantitative PCR. Cell cycle analysis was done by staining the cells with PI and analyzing them by flowcytometry instrument. While the expression of LEF1 in SW480 transfected with pSilencer-antiLEF1 reduced to 0.004 in comparison to non-transfected cells in HCT116 cells transfected with pSilencer-anti LEF1 this value was 0.000002 in comparison to non-transfected cells. Whereas the LC50 of 5-Flurouracil on non-transfected HCT116 and SW480 for 5-FU were 0.55 ng/µl and 1.45 ng/µl respectively. These values in transfected cells reduced to 0.18 and 0.1 ng/µl respectively. The percentages of proliferating cells (G2+S) stably transfected cells reduced to 30% and 32% in comparison to 39% and 45% in SW480 and HCT116 cell lines respectively. These findings showed that silencing LEF1 as a main component of wnt signaling pathway sensitizes HCT116 and SW480 cells to 5-flurouracil. The difference between sensitizing strength may be due to mutations in other components of wnt signaling pathway or mutations in other genes like p53 and k-ras which is dissimilar between HCT116 and SW480 cells. This modality can be considered as sensitizing agents adjuvant to other chemotherapeutic drugs like 5-FU. Note: This abstract was not presented at the conference. Citation Format: Ladan Teimoori-Toolabi, Elham Fakhr, Fatemeh Zare. Silencing LEF1 decreases the resistance of colorectal cancer cell lines to 5-FU as common chemotherapeutic drug. [abstract]. In: Proceedings of the AACR Special Conference on Colorectal Cancer: From Initiation to Outcomes; 2016 Sep 17-20; Tampa, FL. Philadelphia (PA): AACR; Cancer Res 2017;77(3 Suppl):Abstract nr A19.

HeLa

10.1158/1538-7445.crc16-a19

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Synthesis, biological evaluation, molecular docking, MD simulation and DFT analysis of new 3-hydroxypyridine-4-one derivatives as anti-tyrosinase and antioxidant agents

Heliyon (2024)

Sara Sadeghian Fatemeh Zare Mehdi Khoshneviszadeh Arian Fathi Hafshejani Farhang Salahshour

Docking (animal)

10.1016/j.heliyon.2024.e35281

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Molecular docking studies, DFT, and ADMET calculations of some flavonoids and their characteristic structural features involved in inhibition of pro-inflammatory enzymes

Natural Product Research (2024)

Farboodniay Jahromi Mohammad Ali Fatemeh Zare Amirhossein Sakhteman Shahrzad Bahadori Hassan Seradj

Inflammation is an immune system response triggered by pathogens, damaged cells, or stimuli. Some regulatory enzymes, such as phosphodiesterase, hyaluronidase, collagenase, and lipoxygenase, play an essential role in the inflammatory process. Polyphenolic compounds, such as flavonoids, are active suppressors of inflammatory cytokines, modulators of transcription factors, and inflammation-related pathways. A set of flavonoid structures was screened and docked against inflammation pathway enzymes. Amentoflavone has been shown to cause interactions with phosphodiesterase enzymes, while Bilobetin and Silibinin demonstrated an increase in binding energy with collagenase enzymes. The retrieved compounds from the docking study were subjected to DFT theory. The results showed that the LUMO orbital is located on the flavonoid part. The thermochemical parameters indicated that Silibinin is more stable than other compounds. The ADMET profile predicted that Silibinin can be used orally among the compounds. Silibinin can be introduced as a promising anti-inflammatory agent demonstrating phosphodiesterase and collagenase inhibitory properties.

Silibinin

Docking (animal)

Hyaluronidase

10.1080/14786419.2024.2368748

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Citations (1)

The stereological, immunohistological, and gene expression studies in an infected ischemic wound in diabetic rats treated by human adipose-derived stem cells and photobiomodulation

Archives of Dermatological Research (2023)

Roohollah Ebrahimpour‐Malekshah Abdollah Amini Atarodalsadat Mostafavinia Houssein Ahmadi Fatemeh Zare

Granulation tissue

Stereology

Stromal vascular fraction

M2 Macrophage

10.1007/s00403-023-02563-z

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Citations (12)

PREVALENCE OF ANXIETY, DEPRESSION AND COPING STYLES IN MYOCARDIAL INFARCTION PATIENTS HOSPITALIZED IN ISFAHAN HOSPITALS

Majallah-i dānishgāh-i ̒ulūm-i pizishkī-i Māzandarān/Journal of Mazandaran University of Medical Sciences (2010)

Reza Bagherian Mohsen Maroufi M Fath Elah Gol Fatemeh Zare

Background and purpose: Coping strategies, anxiety and depressive symptoms are major problems of post myocardial infarction patients. As the number of investigations studying on such complications was limited, this study was to determine the prevalence of anxiety, depressive symptoms and coping styles among post-MI patients. Materials and methods: In a cross-sectional study one hundred consecutive MI patients admitted to the CCU wards of hospitals in Isfahan were recruited. The patients completed Jalowiec Coping questionnaire and Hospital Anxiety and Depression Scale (HADS) sheets. Then the data was analyzed using Chi-squared test, Pearson correlation coefficient, MANCOVA and Covariance. Results: The mean anxiety and depression subscales were 10.22 and 9.28 respectively. Of all cases, 42% and 31% showed anxiety and depressive symptoms, respectively. The means of proportional scores for coping styles were 0.68 for self-reliant and 0.49 for emotive coping styles, which are the most used and the least used methods by the post myocardial infarction patients respectively. Conclusion: Self-reliant, Optimistic, Confrontive and Supportant coping styles were the most coping styles used by post MI patients, in that order. The problem-oriented function of these coping styles dominates the emotional-oriented function.

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