Objective To compare the efficacy,safety and side-effects of IHT of advanced prostate cancer patients.Methods Thirty-six advanced prostate cancer patients were treated with hormonal therapy.The patients were divided into 2 groups,of 28 patients(groupA) used IHT;8 patients(groupB) were treated with castration only.The difference of clinical symptoms,serum PSA,survival rate,and side-effects of 2 groups were compared.Results The relief rates of group A 80.8%(18/28),groupB 70.6%(3/8).The mean serum PSA of group A decreased from 144.3(18.7-996.8)ng/mL to 15.8(0.02-28.9)ng/ml,group B decreased from 142.3(27.1-988.0)ng/mL to 27.6(6.0-62.1)ng/mL.The mean chemical recurrence rates of group A 34.6%(9/28),group B 58.3%(5/8).The mean chemical recurrence time of group A 22(6-65) month,group B 10(6-56) month.The mortality rates of group A 25%(7/28),group B 75%(6/8).85.5%(22/28) of group A were treated with IHT continuously.the side-effects rate of group A was low.Conclusion Bicalutamide is effective and safe as IHT for prostate cancer patients.
